THE DECLINE IN GASTRIC CANCER: EPIDEMIOLOGY OF AN UNPLANNED TRIUMPH
Abstract
CHRISTOPHER P. HOWSON, TOMOHIKO HIYAMA, ERNST L. WYNDER; THE DECLINE IN GASTRIC CANCER: EPIDEMIOLOGY OF AN UNPLANNED TRIUMPH, Epidemiologic Reviews, Volume 8, I
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Overall trends in stomach cancer rates have been steadily declining over the last half century in most populations, hypothesized to be mainly attributable to decline in noncardia gastric cancer.
“Overall trends in stomach cancer rates have been steadily declining over the last half century in most populationshypothesized to be mainly attributable to decline in noncardia gastric cancer”
From Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (2024) · cites this paper as [110]
The decline in noncardia gastric cancer is an unplanned triumph of prevention that includes better preservation and storage of foods as well as a decreased prevalence of H. pylori.
“an unplanned triumph of prevention that includes better preservation and storage of foods as well as a decreased prevalence of H. pylori.110”
From Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (2024) · cites this paper as [110]
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“110 Yet recent studies have pointed to rising trends among younger age groups, particularly in low ‐ incidence populations, 111,112 with concomitant increases in autoimmune gastritis and dysbiosis of the gastric microbiome postulated to be underlying factors for the shift toward tumors occurring…”
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Sasazuki, S., Sasaki, S., & Tsugane, S. (2002) · International Journal of Cancer · doi:10.1002/ijc.10649 · Cited by 155 · see citing works
Duncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., MacKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., et al. (1997) · Comparative Biochemistry and Physiology Part A: Physiology · doi:10.1016/s0300-9629(97)00023-6 · Cited by 147 · see citing works
Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland
Kosunen, T. U., Aromaa, A., Knekt, P., Salomaa, A., Rautelin, H. I. K., Lohi, P., & Heinonen, O. P. (1997) · Epidemiology and Infection · doi:10.1017/s0950268897007565 · Cited by 151 · see citing works
“suffering from active chronic gastritis, peptic ulcers [25] and gastric malignancies [23, 24, 26].”
BackgroundThe Cancer Transition in Japan since 1951
Gersten, O., & Wilmoth, J. R. (2002) · Demographic Research · doi:10.4054/demres.2002.7.5 · Cited by 151 · see citing works
“pylori infection (Howson et al. 1986; Replogle et al. 1996), whereas lung and sometimes liver cancer tend to increase due to excessive smoking and drinking habits, which are facilitated by economic development (Parrish et al.”
BackgroundInfluentialClinical Application of Serum Pepsinogen I and II Levels for Mass Screening to Detect Gastric Cancer
Miki, K., Ichinose, M., Ishikawa, K., et al. (1993) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1993.tb02805.x · Cited by 149 · see citing works
Dikken, J. L., Lemmens, V. E. P. P., Wouters, M. W. J. M., Wijnhoven, B. P. L., Siersema, P. D., Nieuwenhuijzen, G. A. P., van Sandick, J. W., Cats, A., Verheij, M., Coebergh, J. W. W., et al. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.01.009 · Cited by 145 · see citing works
- Authors
- HOWSON, C. P., HIYAMA, T., & WYNDER, E. L.
- Affiliations
- National Academy of Sciences (US)
- Corresponding author
- WYNDER, ERNST L.
- Venue
- Epidemiologic Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 8
- Issue
- 1
- Pages
- 1-27
- ISSN
- 0193-936X (ISSN-L)
- 1478-6729
- OpenAlex
- W1877917243
- Cited by
- 829
- References
- 0
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 33 · 2023: 16 · 2022: 24 · 2021: 15 · 2020: 16 · 2019: 21 · 2018: 13 · 2017: 17 · 2016: 15 · 2015: 20 · 2014: 21 · 2013: 22 · 2012: 18
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epidemiologic Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA32617)
- Topics
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Keywords
- gastric cancer, incidence decline, incidence trends, cancer epidemiology
- MeSH terms
- Female, Humans, Japan, Male, Stomach Neoplasms, United States, Global Health, History, 20th Century
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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