The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.
Open accessAbstract
Although T cells bearing gamma delta T-cell receptors have long been known to be present in the epithelial lining of many organs, their specificity and function remain elusive. In the present study, we examined the intestinal epithelia of T-cell-receptor mutant mice, which were deficient in either gamma delta T cells or alpha beta T cells, and of normal littermates. The absence of gamma delta T cells was associated with a reduction in epithelial cell turnover and a downregulation of the expression of major histocompatibility complex class II molecules. No such effects were observed in alpha beta T-cell-deficient mice. These findings indicate that intraepithelial gamma delta T cells regulate the generation and differentiation of intestinal epithelial cells.
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Cites
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Self-citationExpression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes
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Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells
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Specificity and function of T cells bearing γδ receptors
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Cited by
γδ T cell effector functions: a blend of innate programming and acquired plasticity
Bonneville, M., O'Brien, R. L., & Born, W. K. (2010) · Nature Reviews Immunology · doi:10.1038/nri2781 · Cited by 952
Role of intestinal microbiota and metabolites on gut homeostasis and human diseases
Lin, L., & Zhang, J. (2017) · BMC Immunology · doi:10.1186/s12865-016-0187-3 · Cited by 731
The light and dark sides of intestinal intraepithelial lymphocytes
Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693
Falk, P. G., Hooper, L. V., Midtvedt, T., & Gordon, J. I. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1157-1170.1998 · Cited by 657
γδ T cells in tissue physiology and surveillance
Ribot, J. C., Lopes, N., & Silva-Santos, B. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00452-4 · Cited by 532
Metadata
- Authors
- Komano, H., Fujiura, Y., Kawaguchi, M., Matsumoto, S., Hashimoto, Y., Obana, S., Mombaerts, P., Tonegawa, S., Yamamoto, H., & Itohara, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-06-20
- Volume
- 92
- Issue
- 13
- Pages
- 6147-6151
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1972571085
- Cited by
- 360
- References
- 37
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Komano, H., Fujiura, Y., Kawaguchi, M., Matsumoto, S., Hashimoto, Y., Obana, S., Mombaerts, P., Tonegawa, S., Yamamoto, H., & Itohara, S. (1995). Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.13.6147
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
