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Cited by 731Gut microbiota and healthGastrointestinal motility and disordersInflammatory Bowel Disease

Role of intestinal microbiota and metabolites on gut homeostasis and human diseases

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Lin, Lan, Zhang, Jianqiong·2017·BMC Immunology
DOI 10.1186/s12865-016-0187-3PMC PMC5219689
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Abstract

BACKGROUND: A vast diversity of microbes colonizes in the human gastrointestinal tract, referred to intestinal microbiota. Microbiota and products thereof are indispensable for shaping the development and function of host innate immune system, thereby exerting multifaceted impacts in gut health. METHODS: This paper reviews the effects on immunity of gut microbe-derived nucleic acids, and gut microbial metabolites, as well as the involvement of commensals in the gut homeostasis. We focus on the recent findings with an intention to illuminate the mechanisms by which the microbiota and products thereof are interacting with host immunity, as well as to scrutinize imbalanced gut microbiota (dysbiosis) which lead to autoimmune disorders including inflammatory bowel disease (IBD), Type 1 diabetes (T1D) and systemic immune syndromes such as rheumatoid arthritis (RA). RESULTS: In addition to their well-recognized benefits in the gut such as occupation of ecological niches and competition with pathogens, commensal bacteria have been shown to strengthen the gut barrier and to exert immunomodulatory actions within the gut and beyond. It has been realized that impaired intestinal microbiota not only contribute to gut diseases but also are inextricably linked to metabolic disorders and even brain dysfunction. CONCLUSIONS: A better understanding of the mutual interactions of the microbiota and host immune system, would shed light on our endeavors of disease prevention and broaden the path to our discovery of immune intervention targets for disease treatment.

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Crossref · 10.1186/s12865-016-0187-3

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  • Maintenance of homeostasis for each balanced compositional signature appears important, with disruption of this homeostasis conferring disease susceptibility.

    “What does appear to be important, however, is maintenance of homeostasis for each balanced compositional signature with disruption of this homeostasis conferring disease susceptibility (Lin and Zhang, 2017)”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Lin and Zhang, 2017

    The Review sections “Commensals and gut homeostasis” and “Microbiota and metabolic disorders” say that microbial–host equilibrium is vital for health and that its disruption may contribute to disease. The paper does not establish the claim’s more specific idea that each balanced compositional signature has its own homeostasis to maintain. Page numbers are unavailable in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • This education minimizes the risk of allergic reactions and autoimmune disorders by fostering the body's familiarity with harmless substances.

    “This education minimizes the risk of allergic reactions and autoimmune disorders by fostering the body’s familiarity with harmless substances (16).”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [16]

    The Background says dendritic cells promote tolerance to innocuous antigens, and the Review’s ‘Commensals and gut homeostasis’ section links commensal-induced regulatory T cells to avoiding autoimmune responses. That section also says early-life Clostridium administration might confer resistance to systemic IgE responses in mice, suggesting an approach to allergy. The claim overstates this qualified, partly animal-based evidence as a general reduction in the risk of allergic reactions and autoimmune disorders. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • A diverse and thriving gut microbiota plays a pivotal role in maintaining immunological homeostasis and educating the immune system.

    “A diverse and thriving gut microbiota plays a pivotal role in maintaining immunological homeostasis and educating the immune system.”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [16]

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Cited by

Sorted by citations

Authors
Lin, L., & Zhang, J.
Affiliations
Southeast University (CN)
Corresponding author
  • Lin, Lan
  • Zhang, Jianqiong
ORCID
Venue
BMC Immunology
Publisher
Springer Science and Business Media LLC
Published
2017-01-06
Volume
18
Issue
1
Pages
2-2
ISSN
1471-2172 (ISSN-L)
DOI
10.1186/s12865-016-0187-3
PMC
PMC5219689
OpenAlex
W2568502991
Cited by
731
References
29
Citations by year
2026: 44 · 2025: 65 · 2024: 103 · 2023: 99 · 2022: 98 · 2021: 96 · 2020: 103 · 2019: 47 · 2018: 50 · 2017: 26
FWCI
5.79
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (CN) (81230034)
  • National Natural Science Foundation of China (81371609)
  • Natural Science Foundation of Jiangsu Province (CN) (BK20151133)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
gut microbiota, intestinal homeostasis, gut microbiota metabolites, innate immunity, dysbiosis, inflammatory bowel disease, type 1 diabetes, rheumatoid arthritis, autoimmune disease, intestinal barrier, commensal bacteria, metabolic disorders, brain dysfunction
MeSH terms
Gastrointestinal Microbiome, Animals, Arthritis, Rheumatoid, Diabetes Mellitus, Type 1, DNA, Bacterial, Homeostasis, Humans, Immunity, Innate, Symbiosis, Inflammatory Bowel Diseases, Receptors, Pattern Recognition, Dysbiosis

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