The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
Open accessAbstract
Nitric oxide produced by cytokine-inducible nitric oxide synthase (iNOS) is thought to be important in the pathogenesis of septic shock. To further our understanding of the role of iNOS in normal biology and in a variety of inflammatory disorders, including septic shock, we have used gene targeting to generate a mouse strain that lacks iNOS. Mice lacking iNOS were indistinguishable from wild-type mice in appearance and histology. Upon treatment with lipopolysaccharide and interferon gamma, peritoneal macrophages from the mutant mice did not produce nitric oxide measured as nitrite in the culture medium. In addition, lysates of these cells did not contain iNOS protein by immunoblot analysis or iNOS enzyme activity. In a Northern analysis of total RNA, no iNOS transcript of the correct size was detected. No increases in serum nitrite plus nitrate levels were observed in homozygous mutant mice treated with a lethal dose of lipopolysaccharide, but the mutant mice exhibited no significant survival advantage over wild-type mice. These results show that lack of iNOS activity does not prevent mortality in this murine model for septic shock.
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Cites
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Cited by
Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734
Nitric oxide synthase in innate and adaptive immunity: an update
Bogdan, C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.01.003 · Cited by 862
Microglia Promote the Death of Developing Purkinje Cells
Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00069-8 · Cited by 757
Angiogenesis in the atherosclerotic plaque
Camaré, C., Pucelle, M., Nègre-Salvayre, A., & Salvayre, R. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.007 · Cited by 401
Mastroeni, P., Vazquez-Torres, A., Fang, F. C., Xu, Y., Khan, S., Hormaeche, C. E., & Dougan, G. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.237 · Cited by 399
Metadata
- Authors
- Laubach, V. E., Shesely, E. G., Smithies, O., & Sherman, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-11-07
- Volume
- 92
- Issue
- 23
- Pages
- 10688-10692
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021992999
- Cited by
- 580
- References
- 47
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. https://app.cochat.ai/papers/10.1073/pnas.92.23.10688
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- Laubach, V. E., Shesely, E. G., Smithies, O., & Sherman, P. A. (1995). Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.23.10688
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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