The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart.
Open accessAbstract
Corticotropin-releasing factor (CRF; corticoliberin) regulates the secretion of corticotropin (ACTH) and beta-endorphin and has a broad range of effects on the nervous, endocrine, reproductive, cardiovascular, gastrointestinal, and immune systems. Recently, human, rat, and mouse CRF receptors (CRF-R) have been cloned and functionally and anatomically characterized. We report here the cloning of a second CRF-R cDNA (CRF-RB), which encodes a protein of 431 amino acids, which is 16 amino acids longer and 68% similar to the previously cloned CRF-R, CRF-RA. When transiently expressed in COS-M6 cells, CRF-RB binds CRF with high affinity [Kd = 1.2 (0.57-2.5)nM] and transduces the CRF-stimulated signal of the accumulation of intracellular cAMP, which is inhibited by a CRF antagonist. Comparison of the amino acid sequences of CRF-RB and the previously cloned receptor reveals major differences in the N-terminal domain and in the extracellular loops, whereas the sequences of the intracellular loops are nearly identical. CRF-RB and related transcripts are expressed in the heart, as well as in other tissues, including the gastrointestinal tract, epididymis, and brain.
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Self-citationCloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor
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The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
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Self-citationCRF and CRF receptors: role in stress responsivity and other behaviors
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Self-citationNeuroendocrine pharmacology of stress
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Metadata
- Authors
- Perrin, M., Donaldson, C., Chen, R., Blount, A., Berggren, T., Bilezikjian, L., Sawchenko, P., & Vale, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-28
- Volume
- 92
- Issue
- 7
- Pages
- 2969-2973
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017168736
- Cited by
- 502
- References
- 29
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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