Role of metabolic programming in the modulation of microglia phagocytosis by lipids

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Identification of a unique TGF-β–dependent molecular and functional signature in microglia

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Microglial <scp>M1/M2</scp> polarization and metabolic states

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Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed

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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the Warburg effect in LPS-activated macrophages

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

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Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

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Phagocytosis: An Immunobiologic Process

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Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

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Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

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Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

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Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

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Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

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Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce β-oxidation in white fat

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Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

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TREM2 regulates microglial cell activation in response to demyelination in vivo

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TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

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Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis

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Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

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NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?

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Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals

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Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation

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Microglial diversity by responses and responders

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Lipoprotein lipase maintains microglial innate immunity in obesity.

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Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

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Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination

Bruce, K. D., Gorkhali, S., Given, K., Coates, A. M., Boyle, K. E., Macklin, W. B., & Eckel, R. H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00057 · Cited by 94 · see citing works

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

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Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase Expression

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Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

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Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system

Yang, S., Qin, C., Hu, Z.-W., Zhou, L.-Q., Yu, H.-H., Chen, M., Bosco, D. B., Wang, W., Wu, L.-J., & Tian, D.-S. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105290 · Cited by 232 · see citing works

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation

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Direct and indirect effects of lipids on microglia function

Leyrolle, Q., Layé, S., & Nadjar, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134348 · Cited by 50 · see citing works

Microglia and TREM2

Pocock, J., Vasilopoulou, F., Svensson, E., & Cosker, K. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110020 · Cited by 54 · see citing works

Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation

Tawbeh, A., Raas, Q., Tahri-Joutey, M., Keime, C., Kaiser, R., Trompier, D., Nasser, B., Bellanger, E., Dessard, M., Hamon, Y., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1299314 · Cited by 18 · see citing works

Peroxisomal defects in microglial cells induce a disease-associated microglial signature

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