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The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Open accessAbstract
Expression of glucokinase in hepatocytes and pancreatic 6-cells is of major physiologic importance to mammalian glucose homeostasis. Liver glucokinase catalyzes the first committed step in the disposal of glucose, and beta-cell glucokinase catalyzes a rate-limiting step required for glucose-regulated insulin release. The present study reports the expression of glucokinase in rat glucagon-producing alpha-cells, which are negatively regulated by glucose. Purified rat alpha-cells express glucokinase mRNA and protein with the same transcript length, nucleotide sequence, and immunoreactivity as the beta-cell isoform. Glucokinase activity accounts for more than 50% of glucose phosphorylation in extracts of alpha-cells and for more than 90% of glucose utilization in intact cells. The glucagon-producing tumor MSL-G-AN also contained glucokinase mRNA, protein, and enzymatic activity. These data indicate that glucokinase may serve as a metabolic glucose sensor in pancreatic alpha-cells and, hence, mediate a mechanism for direct regulation of glucagon release by extracellular glucose. Since these cells do not express Glut2, we suggest that glucose sensing does not necessarily require the coexpression of Glut2 and glucokinase.
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Cites
Thorens, B., Sarkar, H. K., Kaback, H. R., & Lodish, H. F. (1988) · Cell · doi:10.1016/0092-8674(88)90051-7 · Cited by 785
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
Matschinsky, F. (1996) · Diabetes · doi:10.2337/diab.45.2.223 · Cited by 721
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
Vionnet, N., Stoffel, M., Takeda, J., Yasuda, K., Bell, G. I., Zouali, H., Lesage, S., Velho, G., Iris, F., Passa, P., et al. (1992) · Nature · doi:10.1038/356721a0 · Cited by 605
Mechanism of glucose-induced insulin secretion.
Hedeskov, C. J. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.2.442 · Cited by 435
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
De Vos, A., Heimberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeleers, D., & Schuit, F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118308 · Cited by 425
Self-citationInterplay of Nutrients and Hormones in the Regulation of Insulin Release*
PIPELEERS, D. G., Schuit, F. C., Veld, P. I. '., Maes, E., Hooghe-Peters, E. L., Winkel, M. V. D., & Gepts, W. (1985) · Endocrinology · doi:10.1210/endo-117-3-824 · Cited by 357
Self-citationA New in Vitro Model for the Study of Pancreatic A and B Cells*
PIPELEERS, D. G., Veld, P. I. '., Winkel, M. V. D., Maes, E., Schuit, F. C., & Gepts, W. (1985) · Endocrinology · doi:10.1210/endo-117-3-806 · Cited by 341
Self-citationMammalian glucokinase and its gene
Iynedjian, P. B. (1993) · Biochemical Journal · doi:10.1042/bj2930001 · Cited by 337
Unger, R. H., & Orci, L. (1981) · New England Journal of Medicine · doi:10.1056/nejm198106183042504 · Cited by 303
Jetton, T. L., Liang, Y. T., Pettepher, C. C., Zimmerman, E. C., Cox, F., Horvath, K., Matschinsky, F. M., & Magnuson, M. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41910-7 · Cited by 279
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Schuit, F., De Vos, A., Farfari, S., Moens, K., Pipeleers, D., Brun, T., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18572 · Cited by 421
Self-citationPhysiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes
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Self-citationLevin, B. E., Routh, V. H., Kang, L., Sanders, N. M., & Dunn-Meynell, A. A. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2521 · Cited by 377
Kang, L., Routh, V. H., Kuzhikandathil, E. V., Gaspers, L. D., & Levin, B. E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.549 · Cited by 312
Franklin, I., Gromada, J., Gjinovci, A., Theander, S. S., & Wollheim, C. B. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1808 · Cited by 304
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Gremlich, S., Bonny, C., Waeber, G., & Thorens, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30261 · Cited by 276
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Wang, H.-Y., Maechler, P., Ritz-Laser, B., Hagenfeldt, K., Ishihara, H., Philippe, J., & Wollheim, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101233200 · Cited by 175
Gromada, J., Ma, X., Høy, M., Bokvist, K., Salehi, A., Berggren, P.-O., & Rorsman, P. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s181 · Cited by 164
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Self-citationA Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status*
Lenzen, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.557314 · Cited by 140
Olsen, H. L., Theander, S., Bokvist, K., Buschard, K., Wollheim, C. B., & Gromada, J. (2005) · Endocrinology · doi:10.1210/en.2005-0800 · Cited by 156
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Serup, P., Jensen, J. N., Andersen, F. G., Jørgensen, M. C., Blume, N., Holst, J. J., & Madsen, O. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9015 · Cited by 136
Self-citationMetabolic sensing neurons and the control of energy homeostasis
Levin, B. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.07.003 · Cited by 126
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Zhu, D., Li, X., Ma, J., Zeng, J., Gan, S., Dong, X., Yang, J., Lin, X., Cai, H., Song, W., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01802-6 · Cited by 94
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Bin‐Jaliah, I., Maskell, P., & Kumar, P. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058321 · Cited by 95
Rorsman, P., Ramracheya, R. D., Rorsman, N. J. G., & Zhang, Q. (2014) · Diabetologia · doi:10.1007/s00125-014-3279-8 · Cited by 93
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Self-citationQuoix, N., Cheng, R., Mattart, L., Zeinoun, Z., Guiot, Y., Beauvois, M. C., Henquin, J., & Gilon, P. (2008) · Diabetes · doi:10.2337/db07-1298 · Cited by 80
Glucagon secretion and signaling in the development of diabetes
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The physiological role of glucokinase binding and translocation in hepatocytes
Agius, L. (1998) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(97)00001-0 · Cited by 67
Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia
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Kang, L., Sanders, N. M., Dunn-Meynell, A. A., Gaspers, L. D., Routh, V. H., Thomas, A. P., & Levin, B. E. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00645.2007 · Cited by 38
Comstock, S. M., Pound, L. D., Bishop, J. M., Takahashi, D. L., Kostrba, A. M., Smith, M. S., & Grove, K. L. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.11.001 · Cited by 35
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Briaud, I., Rouault, C., Reach, G., & Poitout, V. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90079-3 · Cited by 34
Rabbani, N., & Thornalley, P. J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1268308 · Cited by 36
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One-step purification of functional human and rat pancreatic alpha cells
Köhler, M. G., Daré, E., Ali, M. Y., Rajasekaran, S. S., Moede, T., Leibiger, B., Leibiger, I. B., Tibell, A., Juntti‐Berggren, L., & Berggren, P. (2012) · Integrative Biology · doi:10.1039/c2ib00125j · Cited by 30
Hjortoe, G. M., Hagel, G. M., Terry, B. R., Thastrup, O., & Arkhammar, P. O. G. (2004) · Acta Diabetologica · doi:10.1007/s00592-004-0164-9 · Cited by 28
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Farhy, L. S., Du, Z., Zeng, Q., Veldhuis, P. P., Johnson, M. L., Brayman, K. L., & McCall, A. L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90372.2008 · Cited by 19
Filipski, K. J., Futatsugi, K., Pfefferkorn, J. A., & Stevens, B. D. (2012) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.12.26 · Cited by 16
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Metadata
- Authors
- Heimberg, H., De Vos, A., Moens, K., Quartier, E., Bouwens, L., Pipeleers, D., Van Schaftingen, E., Madsen, O., & Schuit, F.
- Affiliations
- Vrije Universiteit Brussel (BE)
- Diabetes Research Center, Faculty of Medicine, Vrije Universiteit Brussel, Belgium.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-07-09
- Volume
- 93
- Issue
- 14
- Pages
- 7036-7041
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC38931
- OpenAlex
- W2030386197
- Cited by
- 142
- References
- 36
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 5 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 9
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucokinase, alpha cells, glucagon secretion, glucose detection, glucose phosphorylation, glucose utilization, glucagonoma, GLUT2, glucose homeostasis, pancreatic islets
- MeSH terms
- Animals, Base Sequence, Brain, Cells, Cultured, Glucagon, Glucagonoma, Glucokinase, Glucose, Glutamine, Homeostasis, Insulin, Islets of Langerhans, Liver, Male, Molecular Sequence Data, Monosaccharide Transport Proteins, Pancreatic Neoplasms, RNA, Messenger, Transcription, Genetic, Tumor Cells, Cultured, 1-Methyl-3-isobutylxanthine, Polymerase Chain Reaction, Rats, Wistar, DNA Primers, DNA, Complementary, Glucose Transporter Type 2, Rats
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