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Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development.
Open accessAbstract
Arabidopsis plants transformed with an antisense construct of an Arabidopsis methyltransferase cDNA (METI) have reduced cytosine methylation in CG dinucleotides. Methylation levels in progeny of five independent transformants ranged from 10% to 100% of the wild type. Removal of the antisense construct by segregation in sexual crosses did not fully restore methylation patterns in the progeny, indicating that methylation patterns are subject to meiotic inheritance in Arabidopsis. Plants with decreased methylation displayed a number of phenotypic and developmental abnormalities, including reduced apical dominance, smaller plant size, altered leaf size and shape, decreased fertility, and altered flowering time. Floral organs showed homeotic transformations that were associated with ectopic expression of the floral homeotic genes AGAMOUS and APETALA3 in leaf tissue. These observations suggest that DNA methylation plays an important role in regulating many developmental pathways in plants and that the developmental abnormalities seen in the methyltransferase antisense plants may be due to dysregulation of gene expression.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Cited by
DNA methylation pathways and their crosstalk with histone methylation
Du, J., Johnson, L. M., Jacobsen, S. E., & Patel, D. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4043 · Cited by 1,000
Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation
Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., & Jacobsen, S. E. (2001) · Science · doi:10.1126/science.1059745 · Cited by 938
Transgenerational Epigenetic Effects
Youngson, N. A., & Whitelaw, E. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164445 · Cited by 580
DNA Methylation and Epigenetic Inheritance in Plants and Filamentous Fungi
Martienssen, R. A., & Colot, V. (2001) · Science · doi:10.1126/science.293.5532.1070 · Cited by 517
DNA methylation and chromatin – unraveling the tangled web
Robertson, K. D. (2002) · Oncogene · doi:10.1038/sj.onc.1205609 · Cited by 471
Metadata
- Authors
- Finnegan, E. J., Peacock, W. J., & Dennis, E. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-08-06
- Volume
- 93
- Issue
- 16
- Pages
- 8449-8454
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2156183792
- Cited by
- 718
- References
- 1
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Finnegan, E. J., Peacock, W. J., & Dennis, E. S. (1996). Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.16.8449
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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