The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.
Distinct short-term plasticity at two excitatory synapses in the hippocampus
Open accessAbstract
A single mossy fiber input contains several release sites and is located on the proximal portion of the apical dendrite of CA3 neurons. It is, therefore, well suited to exert a strong influence on pyramidal cell excitability. Accordingly, the mossy fiber synapse has been referred to as a detonator or teacher synapse in autoassociative network models of the hippocampus. The very low firing rates of granule cells [Jung, M. W. & McNaughton, B. L. (1993) Hippocampus 3, 165-182], which give rise to the mossy fibers, raise the question of how the mossy fiber synapse temporally integrates synaptic activity. We have therefore addressed the frequency dependence of mossy fiber transmission and compared it to associational/commissural synapses in the CA3 region of the hippocampus. Paired pulse facilitation had a similar time course, but was 2-fold greater for mossy fiber synapses. Frequency facilitation, during which repetitive stimulation causes a reversible growth in synaptic transmission, was markedly different at the two synapses. At associational/ commissural synapses facilitation occurred only at frequencies greater than once every 10 s and reached a magnitude of about 125% of control. At mossy fiber synapses, facilitation occurred at frequencies as low as once every 40 s and reached a magnitude of 6-fold. Frequency facilitation was dependent on a rise in intraterminal Ca2+ and activation of Ca2+/calmodulin-dependent kinase II, and was greatly reduced at synapses expressing mossy…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Second, it has a unique extent of presynaptic plasticity, including facilitation, post-tetanic potentiation (PTP) [21], and long-term potentiation (LTP) [27].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [27]
Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Short-Term Synaptic Plasticity
Zucker, R. S. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000305 · Cited by 1,450
Computational analysis of the role of the hippocampus in memory
Treves, A., & Rolls, E. T. (1994) · Hippocampus · doi:10.1002/hipo.450040319 · Cited by 1,272
Contrasting properties of two forms of long-term potentiation in the hippocampus
Nicoll, R. A., & Malenka, R. C. (1995) · Nature · doi:10.1038/377115a0 · Cited by 861
Self-citationSpatial selectivity of unit activity in the hippocampal granular layer
Jung, M. W., & McNaughton, B. L. (1993) · Hippocampus · doi:10.1002/hipo.450030209 · Cited by 789
Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
Adler, E., Augustine, G., Duffy, S., & Charlton, M. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-06-01496.1991 · Cited by 624
Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP
Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618
Self-citationHuang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490
Temporal Information Transformed into a Spatial Code by a Neural Network with Realistic Properties
Buonomano, D. V., & Merzenich, M. M. (1995) · Science · doi:10.1126/science.7863330 · Cited by 457
Chicurel, M. E., & Harris, K. M. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903250204 · Cited by 417
Research works printed but not linked: 3
- C Yamamoto, S Sawada, S Takada Exp Brain Res 51, 128–134 (1983).
- L H Hamlyn J Anat 96, 112–126 (1962).
- B L McNaughton, L Nadel Neuroscience and Correctionist Theory, eds M A Gluck, D S Rumelhert (Erlbaum), pp. 1–60 (1990).
Cited by
Sorted by citations
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
(1998) · The MIT Press eBooks · doi:10.7551/mitpress/5704.001.0001 · Cited by 1,131
Synaptic plasticity at hippocampal mossy fibre synapses
Nicoll, R. A., & Schmitz, D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1786 · Cited by 653
Self-citationCalcium- and activity-dependent synaptic plasticity
Zucker, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80045-2 · Cited by 618
Geiger, J. R. P., & Jónás, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00164-1 · Cited by 621
Metadata
- Authors
- Salin, P. A., Scanziani, M., Malenka, R. C., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-11-12
- Volume
- 93
- Issue
- 23
- Pages
- 13304-13309
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC24088
- OpenAlex
- W2055775269
- Cited by
- 438
- References
- 25
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 13 · 2023: 19 · 2022: 12 · 2021: 17 · 2020: 17 · 2019: 15 · 2018: 20 · 2017: 15 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 15 · 2012: 10
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- mossy fiber synapses, short-term plasticity, frequency facilitation, paired-pulse facilitation, CA3 pyramidal cells, granule cells, long-term potentiation, synaptic integration, hippocampus
- MeSH terms
- Animals, Calcium, Egtazic Acid, Evoked Potentials, Guinea Pigs, Hippocampus, Magnesium, Nerve Fibers, Neuronal Plasticity, Neurons, Quinoxalines, Synapses, Time Factors, 4-Aminopyridine, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Calcium-Calmodulin-Dependent Protein Kinases, Pyramidal Cells, Receptors, AMPA, 6-Cyano-7-nitroquinoxaline-2,3-dione, Calcium-Calmodulin-Dependent Protein Kinase Type 2, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
