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Distinct short-term plasticity at two excitatory synapses in the hippocampus
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A single mossy fiber input contains several release sites and is located on the proximal portion of the apical dendrite of CA3 neurons. It is, therefore, well suited to exert a strong influence on pyramidal cell excitability. Accordingly, the mossy fiber synapse has been referred to as a detonator or teacher synapse in autoassociative network models of the hippocampus. The very low firing rates of granule cells [Jung, M. W. & McNaughton, B. L. (1993) Hippocampus 3, 165-182], which give rise to the mossy fibers, raise the question of how the mossy fiber synapse temporally integrates synaptic activity. We have therefore addressed the frequency dependence of mossy fiber transmission and compared it to associational/commissural synapses in the CA3 region of the hippocampus. Paired pulse facilitation had a similar time course, but was 2-fold greater for mossy fiber synapses. Frequency facilitation, during which repetitive stimulation causes a reversible growth in synaptic transmission, was markedly different at the two synapses. At associational/ commissural synapses facilitation occurred only at frequencies greater than once every 10 s and reached a magnitude of about 125% of control. At mossy fiber synapses, facilitation occurred at frequencies as low as once every 40 s and reached a magnitude of 6-fold. Frequency facilitation was dependent on a rise in intraterminal Ca2+ and activation of Ca2+/calmodulin-dependent kinase II, and was greatly reduced at synapses expressing mossy…
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“Second, it has a unique extent of presynaptic plasticity, including facilitation, post-tetanic potentiation (PTP) [21], and long-term potentiation (LTP) [27].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [27]
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Metadata
- Authors
- Salin, P. A., Scanziani, M., Malenka, R. C., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-11-12
- Volume
- 93
- Issue
- 23
- Pages
- 13304-13309
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC24088
- OpenAlex
- W2055775269
- Cited by
- 438
- References
- 25
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 13 · 2023: 19 · 2022: 12 · 2021: 17 · 2020: 17 · 2019: 15 · 2018: 20 · 2017: 15 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 15 · 2012: 10
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- mossy fiber synapses, short-term plasticity, frequency facilitation, paired-pulse facilitation, CA3 pyramidal cells, granule cells, long-term potentiation, synaptic integration, hippocampus
- MeSH terms
- Animals, Calcium, Egtazic Acid, Evoked Potentials, Guinea Pigs, Hippocampus, Magnesium, Nerve Fibers, Neuronal Plasticity, Neurons, Quinoxalines, Synapses, Time Factors, 4-Aminopyridine, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Calcium-Calmodulin-Dependent Protein Kinases, Pyramidal Cells, Receptors, AMPA, 6-Cyano-7-nitroquinoxaline-2,3-dione, Calcium-Calmodulin-Dependent Protein Kinase Type 2, In Vitro Techniques
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