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BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases
Open accessAbstract
Expression of BAX, without another death stimulus, proved sufficient to induce a common pathway of apoptosis. This included the activation of interleukin 1β-converting enzyme (ICE)-like proteases with cleavage of the endogenous substrates poly(ADP ribose) polymerase and D4-GDI (GDP dissociation inhibitor for the rho family), as well as the fluorogenic peptide acetyl-Asp-Glu-Val-Asp-aminotrifluoromethylcoumarin (DEVD-AFC). The inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (zVAD-fmk) successfully blocked this protease activity and prevented FAS-induced death but not BAX-induced death. Blocking ICE-like protease activity prevented the cleavage of nuclear and cytosolic substrates and the DNA degradation that followed BAX induction. However, the fall in mitochondrial membrane potential, production of reactive oxygen species, cytoplasmic vacuolation, and plasma membrane permeability that are downstream of BAX still occurred. Thus, BAX-induced alterations in mitochondrial function and subsequent cell death do not apparently require the known ICE-like proteases.
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003
Self-citationTranscriptional Activation by Tetracyclines in Mammalian Cells
Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., & Bujard, H. (1995) · Science · doi:10.1126/science.7792603 · Cited by 2,488
Cited by
Endonuclease G is an apoptotic DNase when released from mitochondria
Li, L. Y., Luo, X., & Wang, X. (2001) · Nature · doi:10.1038/35083620 · Cited by 1,787
The proto-oncogene Bcl-2 and its role in regulating apoptosis
Kroemer, G. (1997) · Nature Medicine · doi:10.1038/nm0697-614 · Cited by 1,739
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
Marzo, I., Brenner, C., Zamzami, N., Jürgensmeier, J. M., Susin, S. A., Vieira, H. L. A., Prévost, M.-C., Xie, Z., Matsuyama, S., Reed, J. C., et al. (1998) · Science · doi:10.1126/science.281.5385.2027 · Cited by 1,168
Gross, A., Yin, X.-M., Wang, K., Wei, M. C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Tempst, P., & Korsmeyer, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1156 · Cited by 1,045
Self-citationEskes, R., Antonsson, B., Osen-Sand, A., Montessuit, S., Richter, C., Sadoul, R., Mazzei, G., Nichols, A., & Martinou, J.-C. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.1.217 · Cited by 651
Colell, A., Ricci, J.-E., Tait, S., Milasta, S., Maurer, U., Bouchier-Hayes, L., Fitzgerald, P., Guio-Carrion, A., Waterhouse, N. J., Li, C. W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.045 · Cited by 516
Ricci, J.-E., Gottlieb, R. A., & Green, D. R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208089 · Cited by 504
A fate worse than death: apoptosis as an oncogenic process
Ichim, G., & Tait, S. W. G. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.58 · Cited by 451
IL-7 Enhances the Survival and Maintains the Size of Naive T Cells
Rathmell, J. C., Farkash, E. A., Gao, W., & Thompson, C. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6869 · Cited by 459
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
Tzung, S.-P., Kim, K. M., Basañez, G., Giedt, C. D., Simon, J., Zimmerberg, J., Zhang, K. Y. J., & Hockenbery, D. M. (2001) · Nature Cell Biology · doi:10.1038/35055095 · Cited by 452
LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-α
Xaus, J., Comalada, M., Valledor, A. F., Lloberas, J., López-Soriano, F., Argilés, J. M., Bogdan, C., & Celada, A. (2000) · Blood · doi:10.1182/blood.v95.12.3823 · Cited by 331
Banki, K., Hutter, E., Gonchoroff, N. J., & Perl, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1466 · Cited by 276
Apoptosis of Retinal Ganglion Cells in Glaucoma
Nickells, R. W. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00029-6 · Cited by 232
Activation of caspase-3 in β-amyloid-induced apoptosis of cultured rat cortical neurons
Harada, J., & Sugimoto, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01808-9 · Cited by 184
Abnormal T cell signal transduction in systemic lupus erythematosus
Kammer, G. M., Perl, A., Richardson, B. C., & Tsokos, G. C. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10192 · Cited by 139
Zoledronate Sensitizes Endothelial Cells to Tumor Necrosis Factor-induced Programmed Cell Death
Bezzi, M., Hasmim, M., Bieler, G., Dormond, O., & Rüegg, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308114200 · Cited by 139
Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals
Marques, C., Mega, C., Gonçalves, A., Rodrigues-Santos, P., Teixeira-Lemos, E., Teixeira, F., Fontes-Ribeiro, C., Reis, F., & Fernandes, R. (2014) · Mediators of Inflammation · doi:10.1155/2014/538737 · Cited by 126
“The authors report no conflict of interests.”
The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program
Elliott, K., Ge, K., Du, W., & Prendergast, G. C. (2000) · Oncogene · doi:10.1038/sj.onc.1203681 · Cited by 106
O'Sullivan, M. P., O'Leary, S., Kelly, D. M., & Keane, J. (2007) · Infection and Immunity · doi:10.1128/iai.01107-06 · Cited by 74
Deacetylation of p53 induces autophagy by suppressing Bmf expression
Contreras, A. U., Mebratu, Y., Delgado, M., Montano, G., Hu, C.-A. A., Ryter, S. W., Choi, A. M. K., Lin, Y., Xiang, J., Chand, H., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201205064 · Cited by 48
Self-citation
Metadata
- Authors
- Xiang, J., Chao, D. T., & Korsmeyer, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-12-10
- Volume
- 93
- Issue
- 25
- Pages
- 14559-14563
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077987011
- Cited by
- 884
- References
- 2
- FWCI
- 33.64
- Type
- journal article
- Language
- en
- Open access
- green
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