GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation
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In cells undergoing apoptosis, mitochondrial outer-membrane permeabilization (MOMP) is followed by caspase activation promoted by released cytochrome c. Although caspases mediate the apoptotic phenotype, caspase inhibition is generally not sufficient for survival following MOMP; instead cells undergo a "caspase-independent cell death" (CICD). Thus, MOMP may represent a point of commitment to cell death. Here, we identify glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a critical regulator of CICD. GAPDH-expressing cells preserved their clonogenic potential following MOMP, provided that caspase activation was blocked. GAPDH-mediated protection of cells from CICD involved an elevation in glycolysis and a nuclear function that correlated with and was replaced by an increase in Atg12 expression. Consistent with this, protection from CICD reflected an increase in and a dependence upon autophagy, associated with a transient decrease in mitochondrial mass. Therefore, GAPDH mediates an elevation in glycolysis and enhanced autophagy that cooperate to protect cells from CICD.
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Redox changes may also affect posttranslational modifications of GAPDH, altering its binding to mRNA, metabolites, as well as its localization within the cell.
“Redox changes may also affect posttranslational modifications of GAPDH, altering its binding to mRNA, metabolites, as well as its localization within the cell (113, 114).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [113]
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- Authors
- Colell, A., Ricci, J.-E., Tait, S., Milasta, S., Maurer, U., Bouchier-Hayes, L., Fitzgerald, P., Guio-Carrion, A., Waterhouse, N. J., Li, C. W., Mari, B., Barbry, P., Newmeyer, D. D., Beere, H. M., & Green, D. R.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Inserm (FR)
- St. Jude Children's Research Hospital (US)
- University of Freiburg (DE)
- The University of Melbourne (AU)
- La Jolla Institute for Immunology (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Green, Douglas R.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 129
- Issue
- 5
- Pages
- 983-997
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1965129178
- Cited by
- 516
- References
- 70
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 16 · 2023: 18 · 2022: 25 · 2021: 24 · 2020: 25 · 2019: 23 · 2018: 23 · 2017: 26 · 2016: 17 · 2015: 33 · 2014: 34 · 2013: 36 · 2012: 37
- FWCI
- 15.48
- Type
- journal article
- Language
- en
- Update notices
- erratum (2007-07-27)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI040646, AI40646)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- glyceraldehyde-3-phosphate dehydrogenase, caspase-independent cell death, cytochrome c release, mitochondrial outer membrane permeabilization, autophagy, glycolysis, ATG12, mitochondrial mass, cell survival, apoptosis
- MeSH terms
- Autophagy, Cell Survival, Glyceraldehyde-3-Phosphate Dehydrogenases, HeLa Cells, Humans, Mitochondria, Apoptosis, Jurkat Cells, Caspases, RNA Interference, Cytochromes c, Mitochondrial Membranes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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