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Cited by 94Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Novel expression mechanism for synaptic potentiation: Alignment of presynaptic release site and postsynaptic receptor

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Xie, Xiaping, Liaw, Jim-Shih, Baudry, Michel, Berger, Theodore W.·1997·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.94.13.6983PMC PMC21271
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Abstract

A combination of experimental and modeling approaches was used to study cellular-molecular mechanisms underlying the expression of short-term potentiation (STP) and long-term potentiation (LTP) of glutamatergic synaptic transmission in the hippocampal slice. Electrophysiological recordings from dentate granule cells revealed that high-frequency stimulation of perforant path afferents induced a robust STP and LTP of both (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and N-methyl-D-aspartic acid (NMDA) receptor-mediated synaptic responses. However, the decay time constant for STP of the AMPA receptor-mediated excitatory postsynaptic potential was approximately 6 min, whereas the decay time constant for STP of the NMDA receptor-mediated excitatory postsynaptic potential was only 1 min. In addition, focal application of agonists during the expression of STP revealed that the magnitude of conductance change elicited by NMDA application was significantly enhanced, whereas the magnitude of conductance change elicited by application of AMPA remained constant. These findings are most consistent with a postsynaptic mechanism of STP and LTP. Different putative mechanisms were evaluated formally using a computational model that included diffusion of glutamate within the synaptic cleft, different kinetic properties of AMPA and NMDA receptor/channels, and geometric relations between presynaptic release sites and postsynaptic receptor/channels. Simulation results revealed that the only hypothesis consistent with experimental data is that STP and LTP reflect a relocation of AMPA receptor/channels in the postsynaptic membrane such that they become more closely "aligned" with presynaptic release sites. The same mechanism cannot account for STP or LTP of NMDA receptor-mediated responses; instead, potentiation of the NMDA receptor subtype is most consistent with an increase in receptor sensitivity or number.

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The relationship between channel opening probability and distance from a release site is Po(r)=0.42e-r/88nm.

    “Central to this approach is the relationship between channel opening probability and its distance from a release site, determined previously by stochastic modeling approaches3,16,47: (6)Po(r)=0.42e-r/88nm”

    From A trans-synaptic nanocolumn aligns neurotransmitter release to receptors (2016) · cites this paper as [47]

    The Results report simulations in which receptor distance from the release site affects AMPA-mediated responses, and the Discussion says response amplitude increases with proximity. But our copy does not give an opening-probability equation or the claimed 0.42 coefficient and 88-nm decay length; its 42% figure is a comparison of EPSC amplitudes, not an opening probability. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Xie, X., Liaw, J.-S., Baudry, M., & Berger, T. W.
Affiliations
University of Southern California (US)
ORCID
Baudry, Michel
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1997-06-24
Volume
94
Issue
13
Pages
6983-6988
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.94.13.6983
PMC
PMC21271
OpenAlex
W1968945882
Cited by
94
References
2
Citations by year
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FWCI
2.89
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
synaptic potentiation, short-term potentiation, long-term potentiation, postsynaptic mechanisms, AMPA receptors, NMDA receptor, glutamate diffusion, synaptic cleft, presynaptic release sites, dentate gyrus granule cells, perforant path, hippocampus
MeSH terms
Animals, Electrophysiology, Hippocampus, Models, Neurological, Synaptic Transmission, Rabbits, Synapses, Receptors, N-Methyl-D-Aspartate, Presynaptic Terminals, Receptors, AMPA

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