The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
An interleukin 4 (IL-4)-independent pathway for CD4+T cell IL-4 production is revealed in IL-4 receptor-deficient mice
Open accessAbstract
IL-4 receptor α chain (IL-4Rα)-deficient mice were generated by gene-targeting in BALB/c embryonic stem cells. Mutant mice showed a loss of IL-4 signal transduction and functional activity. The lack of IL-4Rα resulted in markedly diminished, but not absent, TH2 responses after infection with the helminthic parasite Nippostrongylus brasiliensis. CD4+, CD62L-high, and CD62L-low T cell populations from uninfected IL-4Rα−/−mice were isolated by cell sorting. Upon primary stimulation by T cell receptor cross-linkage, the CD62L-low, but not the CD62L-high, cells secreted considerable amounts of IL-4, which was strikingly enhanced upon 4-day culture with anti-CD3 in the presence or absence of IL-4. CD62L-low cells isolated from IL-4Rα−/−, β 2-microglobulin−/−double homozygous mice produced less IL-4 than did either IL-4Rα−/−or wild-type mice. These results indicate that an IL-4-independent, β 2-microglobulin-dependent pathway exists through which the CD62L-low CD4+population has acquired IL-4-producing capacity in vivo, strongly suggesting that these cells are NK T cells.
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Cites
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Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
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Essential role of Stat6 in IL-4 signalling
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MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
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Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
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Self-citationInterleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor
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Cited by
The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545
IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo
Fort, M. M., Cheung, J., Yen, D., Li, J., Zurawski, S. M., Lo, S., Menon, S., Clifford, T., Hunte, B., Lesley, R., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00243-6 · Cited by 1,203
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 958
Distinct macrophage phenotypes contribute to kidney injury and repair
Lee, S., Huen, S., Nishio, H., Nishio, S., Lee, H. K., Choi, B.-S., Ruhrberg, C., & Cantley, L. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060615 · Cited by 906
Targeting key proximal drivers of type 2 inflammation in disease
Gandhi, N. A., Bennett, B. L., Graham, N. M. H., Pirozzi, G., Stahl, N., & Yancopoulos, G. D. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd4624 · Cited by 766
Metadata
- Authors
- Noben-Trauth, N., Shultz, L. D., Brombacher, F., Urban, J. F., Gu, H., & Paul, W. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-09-30
- Volume
- 94
- Issue
- 20
- Pages
- 10838-10843
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043189165
- Cited by
- 344
- References
- 39
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: An interleukin 4 (IL-4)-independent pathway for CD4+T cell IL-4 production is revealed in IL-4 receptor-deficient mice. https://app.cochat.ai/papers/10.1073/pnas.94.20.10838
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- Noben-Trauth, N., Shultz, L. D., Brombacher, F., Urban, J. F., Gu, H., & Paul, W. E. (1997). An interleukin 4 (IL-4)-independent pathway for CD4+T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.20.10838
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
