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Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
Open accessAbstract
Inflammation with expression of interleukin 6 (IL-6) in the brain occurs in many neurodegenerative disorders. To better understand the role of IL-6 in such disorders, we examined performance in a learning task in conjunction with molecular and cellular neuropathology in transgenic mice that express IL-6 chronically from astrocytes in the brain. Transgenic mice exhibited dose- and age-related deficits in avoidance learning that closely corresponded with specific progressive neuropathological changes. These results establish a link between the central nervous system expression of IL-6, inflammatory neurodegeneration, and a learning impairment in transgenic mice. They suggest a critical role for a proinflammatory cytokine in the cognitive deficits and associated neuroinflammatory changes that have been documented in neurodegenerative diseases such as Alzheimer disease and AIDS.
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Metadata
- Authors
- Heyser, C. J., Masliah, E., Samimi, A., Campbell, I. L., & Gold, L. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-02-18
- Volume
- 94
- Issue
- 4
- Pages
- 1500-1505
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093844611
- Cited by
- 386
- References
- 2
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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