Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults
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Background Converging animal findings suggest that higher peripheral levels of inflammation are associated with activation of central inflammatory mechanisms that result in hippocampal neurodegeneration and related impairment of memory function. We have recently shown, consistent with animal findings, an inverse association between peripheral levels of interleukin-6 (IL-6), a relatively stable marker of systemic inflammation, and memory function in mid-life adults. In the current study, we extend this work to test whether systemic inflammation is associated with reduced grey matter volume of the hippocampus.Methods For this purpose, we used a computational structural neuroimaging method (optimized voxel-based morphometry) to evaluate the relationship between plasma IL-6 levels and hippocampal grey matter volume in a sample of 76 relatively healthy community volunteers ages 30-54.Results Peripheral levels of IL-6 covaried inversely with hippocampal grey matter volume, and this relationship persisted after accounting for several possible confounders, including age, gender, race, years of education, percent body fat, blood pressure, smoking, physical activity, hours of sleep, alcohol use, and total grey matter volume.Conclusions To our knowledge, this is the first report of a relationship between a peripheral marker of IL-6 and hippocampal grey matter volume, raising the possibility that low-grade systemic inflammation could plausibly presage subclinical cognitive decline in part via structural neural pathways.
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Several high-quality studies found no relationship between self-reported and objective short sleep duration and markers of inflammation.
“Several high-quality studies have found no relationship between self-reported and objective (ie, polysomnographic) short sleep duration and markers of inflammation (Larkin et al, 2005;Taheri et al, 2007;Marsland et al, 2008;Lee et al, 2009;Rief et al, 2010;Ramey et al, 2012)”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Marsland et al, 2008
Inflammatory processes in the body are associated with reductions in volume of the hippocampus and poor sleep.
“Accumulating evidence also indicates that inflammatory processes in the body are associated with reductions in volume of a key brain structure, the hippocampus 55 as well as poor sleep 56”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [55]
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- Authors
- Marsland, A. L., Gianaros, P. J., Abramowitch, S. M., Manuck, S. B., & Hariri, A. R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Marsland, Anna L.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 64
- Issue
- 6
- Pages
- 484-490
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2562462
- OpenAlex
- W2010397126
- Cited by
- 348
- References
- 64
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 22 · 2023: 22 · 2022: 14 · 2021: 26 · 2020: 26 · 2019: 26 · 2018: 19 · 2017: 13 · 2016: 22 · 2015: 20 · 2014: 31 · 2013: 25 · 2012: 16
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart and Lung Institute
- National Institute of Mental Health
- National Institute of Nursing Research
- Australian Rotary Health
- John D. and Catherine T. MacArthur Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- interleukin-6, systemic inflammation, hippocampal neurodegeneration, memory function, middle-aged adults, plasma biomarkers, neuroinflammation
- MeSH terms
- Adipose Tissue, Adult, Cognition Disorders, Female, Hippocampus, Humans, Hypertension, Inflammation, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Registries, Severity of Illness Index, Wechsler Scales, Interleukin-6, Diagnostic and Statistical Manual of Mental Disorders
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