Cited by 254Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeurogenesis and neuroplasticity mechanisms

Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

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Donzis, Elissa J., Tronson, Natalie C.·2014·Neurobiology of Learning and Memory

Abstract

This review describes the role of cytokines and their downstream signaling cascades on the modulation of learning and memory. Immune proteins are required for many key neural processes and dysregulation of these functions by systemic inflammation can result in impairments of memory that persist long after the resolution of inflammation. Recent research has demonstrated that manipulations of individual cytokines can modulate learning, memory, and synaptic plasticity. The many conflicting findings, however, have prevented a clear understanding of the precise role of cytokines in memory. Given the complexity of inflammatory signaling, understanding its modulatory role requires a shift in focus from single cytokines to a network of cytokine interactions and elucidation of the cytokine-dependent intracellular signaling cascades. Finally, we propose that whereas signal transduction and transcription may mediate short-term modulation of memory, long-lasting cellular and molecular mechanisms such as epigenetic modifications and altered neurogenesis may be required for the long lasting impact of inflammation on memory and cognition.

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Crossref · 10.1016/j.nlm.2014.08.008

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  1. Albensi BC Mattson MP 2000 Evidence for the involvement of TNF and NF-κB in hippocampal synaptic plasticity Synapse 35 2 151 159 10611641

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Authors
Donzis, E. J., & Tronson, N. C.
Affiliations
University of Michigan (US)
Corresponding author
Tronson, Natalie C.
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2014-11
Volume
115
Pages
68-77
ISSN
1074-7427 (ISSN-L)
OpenAlex
W1994707167
Cited by
254
References
165
Citations by year
2026: 11 · 2025: 13 · 2024: 11 · 2023: 17 · 2022: 15 · 2021: 32 · 2020: 36 · 2019: 39 · 2018: 32 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 1
FWCI
1.27
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health R00 (MH093459)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
cytokines, learning and memory, neuroinflammation, synaptic plasticity, epigenetic modifications, neurogenesis, memory impairment, cognitive impairment, signal transduction
MeSH terms
Animals, Humans, Learning, Memory, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Cytokines, Interleukin-1beta

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