The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
Open accessAbstract
cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes. In inflammatory disease such as rheumatoid arthritis, expression patterns of diverse cell types contribute to the pathology. We have monitored gene expression in this disease state with a microarray of selected human genes of probable significance in inflammation as well as with genes expressed in peripheral human blood cells. Messenger RNA from cultured macrophages, chondrocyte cell lines, primary chondrocytes, and synoviocytes provided expression profiles for the selected cytokines, chemokines, DNA binding proteins, and matrix-degrading metalloproteinases. Comparisons between tissue samples of rheumatoid arthritis and inflammatory bowel disease verified the involvement of many genes and revealed novel participation of the cytokine interleukin 3, chemokine Groα and the metalloproteinase matrix metallo-elastase in both diseases. From the peripheral blood library, tissue inhibitor of metalloproteinase 1, ferritin light chain, and manganese superoxide dismutase genes were identified as expressed differentially in rheumatoid arthritis compared with inflammatory bowel disease. These results successfully demonstrate the use of the cDNA microarray system as a general approach for dissecting human diseases.
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Cites
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Self-citationKaminska, B. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.08.017 · Cited by 1,285
Protein Microarrays for Gene Expression and Antibody Screening
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Larrosa, M., Yañéz-Gascón, M. J., Selma, M. V., González-Sarrías, A., Toti, S., Cerón, J. J., Tomás-Barberán, F., Dolara, P., & Espín, J. C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803638d · Cited by 365
Outinen, P. A., Sood, S. K., Pfeifer, S. I., Pamidi, S., Podor, T. J., Li, J., Weitz, J. I., & Austin, R. C. (1999) · Blood · doi:10.1182/blood.v94.3.959.415k20_959_967 · Cited by 349
Metadata
- Authors
- Heller, R. A., Schena, M., Chai, A., Shalon, D., Bedilion, T., Gilmore, J., Woolley, D. E., & Davis, R. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-03-18
- Volume
- 94
- Issue
- 6
- Pages
- 2150-2155
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016799976
- Cited by
- 721
- References
- 21
- FWCI
- 39.09
- Type
- journal article
- Language
- en
- Open access
- green
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