Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model
Abstract
The naturally occurring polyphenol resveratrol has been acknowledged with health-beneficial properties. Most of the studies dealing with its in vivo effects assay huge doses, not representative from a dietary point of view. Our aim was to ascertain whether resveratrol can exert anti-inflammatory activity in vivo at an attainable dietary dose. Rats were fed with 1 mg of resveratrol/kg/day (a human equivalent dose) for 25 days, and in the last 5 days, 5% dextran sulfate sodium (DSS) was administered to induce colitis. Effects on colon tissue damage, gut microbiota, reactive oxygen species, inflammatory markers and nitric oxide production as well as gene expression profile with microarrays were evaluated. Resveratrol increased lactobacilli and bifidobacteria as well as diminished the increase of enterobacteria upon DSS treatment. Resveratrol significantly protected the colonic mucosa architecture, reduced body weight loss, diminished the induced anemia and reduced systemic inflammation markers, colonic mucosa prostaglandin E(2), cycloxygenase-2, prostaglandin E synthase and nitric oxide levels. In addition, the expression of 2,655 genes in distal colon mucosa related to important pathways was varied. These results reinforce the concept of resveratrol as a dietary beneficial compound in intestinal inflammation at doses possibly attainable with resveratrol-enriched nutraceuticals.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resveratrol consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratio and the growth of Bacteroides, Lactobacillus, and Bifidobacterium.
“Moreover, it has been found that RSV consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratios, and the growth of Bacteroides, Lactobacillus, and Bifidobacterium (18–22).”
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027 · see citing works
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works
Dose translation from animal to human studies revisited.
Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9574lsf · Cited by 6,524 · see citing works
Doniger, S. W., Salomonis, N., Dahlquist, K. D., VRANIZAN, K. M., Lawlor, S. C., & Conklin, B. R. (2003) · Genome biology · doi:10.1186/gb-2003-4-1-r7 · Cited by 865 · see citing works
Nutraceuticals: Facts and fiction
Espı́n, J. C., García‐Conesa, M., & Tomás-Barberán, F. A. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.09.014 · Cited by 814 · see citing works
Self-citationDiscovery and analysis of inflammatory disease-related genes using cDNA microarrays
Heller, R. A., Schena, M., Chai, A., Shalon, D., Bedilion, T., Gilmore, J., Woolley, D. E., & Davis, R. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2150 · Cited by 721 · see citing works
Metabolism and bioavailability oftrans-resveratrol
Wenzel, E., & Somoza, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500010 · Cited by 677 · see citing works
Probiotics as modulators of the gut flora
Fooks, L. J., & Gibson, G. R. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002628 · Cited by 499 · see citing works
Candela, M., Perna, F., Carnevali, P., Vitali, B., Ciati, R., Gionchetti, P., Rizzello, F., Campieri, M., & Brigidi, P. (2008) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2008.04.012 · Cited by 400 · see citing works
Lawrance, I. C. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.445 · Cited by 380 · see citing works
Espín, J. C., González-Barrio, R., Cerdá, B., López-Bote, C., Rey, A. I., & Tomás-Barberán, F. A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0723864 · Cited by 352 · see citing works
Self-citationCamacho‐Barquero, L., Villegas, I., Sánchez-Calvo, J. M., Talero, E., Sánchez‐Fidalgo, S., Motilva, V., & Alarcón‐de‐la‐Lastra, C. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.11.006 · Cited by 349 · see citing works
Dolara, P., Luceri, C., Filippo, C. D., Femia, A. P., Giovannelli, L., Caderni, G., Cecchini, C., Silvi, S., Orpianesi, C., & Cresci, A. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.04.022 · Cited by 346 · see citing works
Self-citationA review of the content of the putative chemopreventive phytoalexin resveratrol in red wine
Stervbo, U., Vang, O., & Bonnesen, C. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.01.047 · Cited by 286 · see citing works
Wu, F., Dassopoulos, T., Cope, L., Maitra, A., Brant, S. R., Harris, M. L., Bayless, T. M., Parmigiani, G., & Chakravarti, S. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20110 · Cited by 272 · see citing works
Martín, A. R., Villegas, I., Casa, C. L., & Alarcón‐de‐la‐Lastra, C. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.12.024 · Cited by 258 · see citing works
Effects of Resveratrol in Inflammatory Arthritis
Elmali, N., Baysal, Ö., Harma, A., Esenkaya, İ., & Mızrak, B. (2006) · Inflammation · doi:10.1007/s10753-006-9012-0 · Cited by 251 · see citing works
Martín, A. R., Villegas, I., Sánchéz‐Hidalgo, M., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706469 · Cited by 230 · see citing works
Schneider, Y., Duranton, B., Goss, F., Schleiffer, R., Seiler, N., & Raul, F. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc391_14 · Cited by 200 · see citing works
Oxidative stress markers in preovulatory follicular fluid in humans
Jóźwik, M. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.5.409 · Cited by 177 · see citing works
Li, Z. (2002) · Carcinogenesis · doi:10.1093/carcin/23.9.1531 · Cited by 169 · see citing works
Zamora‐Ros, R., Andrés‐Lacueva, C., Lamuela-Raventós, R. M., Berenguer, T., Jakszyn, P. G., Martínez, C., Sánchez, M., Navarro, C., Chirlaque, M. D., Tormo, M.-J., et al. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507882997 · Cited by 160 · see citing works
Osman, N., Adawi, D., Molin, G., Ahrné, S., Berggren, A., & Jeppsson, B. W. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-31 · Cited by 141 · see citing works
Postharvest Stilbene-Enrichment of Red and White Table Grape Varieties Using UV-C Irradiation Pulses
Cantos‐Villar, E., Espı́n, J. C., & Tomás-Barberán, F. A. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020562x · Cited by 130 · see citing works
Self-citationLarrosa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030073c · Cited by 120 · see citing works
Self-citationGiffen, P. S., Turton, J. A., Andrews, C. M., Barrett, P., Clarke, C. J., Fung, K.-W., Munday, M. R., Roman, I., Smyth, R., Walshe, K., et al. (2003) · Archives of Toxicology · doi:10.1007/s00204-003-0458-7 · Cited by 112 · see citing works
Torres, M., & Ríos, A. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.1972 · Cited by 105 · see citing works
Regulation of Gene Expression in Inflammatory Bowel Disease and Correlation with IBD Drugs
Dooley, T. P., Curto, E. V., Reddy, S. P., et al. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200401000-00001 · Cited by 93 · see citing works
Resveratrol inhibits TNF-α-induced changes of adipokines in 3T3-L1 adipocytes
Ahn, J., Lee, H., Kim, S., & Ha, T. Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.109 · Cited by 89 · see citing works
Inflammatory bowel disease: lessons from the IL-10 gene-deficient mouse.
Madsen, K. L. (2001) · PubMed · Cited by 89 · see citing works
Chang, J., Lai, Y.-H., Djoko, B., et al. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0620766 · Cited by 86 · see citing works
Araki, Y., Andoh, A., Fujiyama, Y., & Bamba, T. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01094.x · Cited by 85 · see citing works
Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis
Ma, Z., Ma, Q., Wang, L.-C., et al. (2005) · Inflammation Research · doi:10.1007/s00011-005-1388-z · Cited by 74 · see citing works
Sasaki, Hirata, Maemura, Hamamoto, Murano, Toshina, & Katsu (2000) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2000.00623.x · Cited by 72 · see citing works
Tardieu, D., Jaeg, J.-P., Cadet, J., Embvani, E., Corpet, D. E., & Petit, C. R. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00228-6 · Cited by 43 · see citing works
Rivera, E., Flores, I., Rivera, E., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000231575.11678.8c · Cited by 35 · see citing works
Luceri, C., Giovannelli, L., Pitozzi, V., et al. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.10.007 · Cited by 29 · see citing works
Liu, Z., Lu, X., Wang, H., et al. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01381.x · Cited by 29 · see citing works
Endocrine changes in women conceiving during treatment with an LHRH agonist
Isherwood, P. J., Ibrahim, Z. H. Z., Matson, P. L., et al. (1990) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137112 · Cited by 17 · see citing works
Resveratrol attenuates inflammation and stricture formation in experimental caustic esophageal burns
Uğuralp, S., Irsi, C., Aksoy, T., et al. (2008) · Pediatric Surgery International · doi:10.1007/s00383-008-2116-x · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Interaction between Phenolics and Gut Microbiota: Role in Human Health
Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324 · see citing works
Self-citationChen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754 · see citing works
Interactions of gut microbiota with functional food components and nutraceuticals
Laparra, J. M., & Sanz, Y. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.11.001 · Cited by 684 · see citing works
Kawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563 · see citing works
A survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396 · see citing works
Qiao, Y., Sun, J., Xia, S., Tang, X., Shi, Y., & Le, G. (2014) · Food & Function · doi:10.1039/c3fo60630a · Cited by 367 · see citing works
Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123720 · Cited by 221 · see citing works
Wellman, A. S., Metukuri, M. R., Kazgan, N., Xu, X., Xu, Q., Ren, N. S. X., Czopik, A., Shanahan, M. T., Kang, A., Chen, W., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.022 · Cited by 191 · see citing works
Linking dietary patterns with gut microbial composition and function
Sheflin, A. M., Melby, C. L., Carbonero, F., & Weir, T. L. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1270809 · Cited by 162 · see citing works
Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota
Bird, J. K., Raederstorff, D., Weber, P., & Steinert, R. E. (2017) · Advances in Nutrition · doi:10.3945/an.117.016568 · Cited by 136 · see citing works
Interaction of dietary resveratrol with animal-associated bacteria
Jung, C. M., Heinze, T. M., Schnackenberg, L. K., Mullis, L. B., Elkins, S. A., Elkins, C. A., Steele, R. S., & Sutherland, J. B. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01691.x · Cited by 86 · see citing works
Different Flavonoids Can Shape Unique Gut Microbiota Profile <i>In Vitro</i>
Huang, J., Chen, L., Xue, B., Liu, Q., Ou, S., Wang, Y., & Peng, X. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13411 · Cited by 52 · see citing works
Azorín-Ortuño, M., Yáñez-Gascón, M. J., González-Sarrías, A., Larrosa, M., Vallejo, F., Pallarés, F. J., Lucas, R., Morales, J. C., Tomás-Barberán, F. A., García-Conesa, M.-T., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.04.007 · Cited by 49 · see citing works
Self-citationZhang, B., Zhang, Y., Liu, X., Zhao, C., Yin, J., Li, X., Zhang, X., Wang, J., & Wang, S. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2022.133904 · Cited by 47 · see citing works
Seoane-Viaño, I., Gómez-Lado, N., Lázare-Iglesias, H., Rey-Bretal, D., Lamela-Gómez, I., Otero-Espinar, F. J., Blanco-Méndez, J., Antúnez-López, J. R., Pombo-Pasín, M., Aguiar, P., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118713 · Cited by 24 · see citing works
- Authors
- Larrosa, M., Yañéz-Gascón, M. J., Selma, M. V., González-Sarrías, A., Toti, S., Cerón, J. J., Tomás-Barberán, F., Dolara, P., & Espín, J. C.
- Affiliations
- Centro de Edafología y Biología Aplicada del Segura (ES)
- Department of Preclinical and Clinical Pharmacology, University of Florence, I-50139 Florence, Italy, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain, and Department of Medicine and Animal Surgery, Faculty of Veterinary, University of Murcia, 30100 Campus de Espinardo, Murcia, Spain
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-02-19
- Volume
- 57
- Issue
- 6
- Pages
- 2211-2220
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1990882347
- Cited by
- 365
- References
- 41
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 28 · 2023: 25 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 31 · 2018: 23 · 2017: 23 · 2016: 12 · 2015: 16 · 2014: 16 · 2013: 9 · 2012: 16
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, dietary polyphenols, colitis, DSS-induced colitis, gut microbiota, anti-inflammatory activity, nitric oxide, prostaglandin E2, cyclooxygenase-2, reactive oxygen species, lactobacilli, Bifidobacterium, Enterobacteriaceae, gene expression, nutraceuticals, inflammatory markers
- MeSH terms
- Resveratrol, Animals, Anti-Inflammatory Agents, Colitis, Colon, Diet, Feces, Male, Rats, Inbred F344, Stilbenes, Dextran Sulfate, Oligonucleotide Array Sequence Analysis, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
