The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
DNA methylation and genetic instability in colorectal cancer cells
Open accessAbstract
Apparent alterations in DNA methylation have been observed in many cancers, but whether such alterations represent a persistent alteration in the normal methylation process is not known. In this study, we report a striking difference in the expression of exogenously introduced retroviral genes in various colorectal cancer cell lines. Extinguished expression was associated with DNA methylation and could be reversed by treatment with the demethylating agent 5-azacytidine. A striking correlation between genetic instability and methylation capacity suggested that methylation abnormalities may play a role in chromosome segregation processes in cancer cells.
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Metadata
- Authors
- Lengauer, C., Kinzler, K. W., & Vogelstein, B.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-03-18
- Volume
- 94
- Issue
- 6
- Pages
- 2545-2550
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2019322535
- Cited by
- 396
- References
- 4
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997). DNA methylation and genetic instability in colorectal cancer cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.6.2545
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