The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585

AChE-stained horizontal sections of the rat brain in stereotaxic coordinates

Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881

Brain Maps: Structure of the Rat Brain

Swanson, L. W. (1992) · Medical Entomology and Zoology · Cited by 1,878

Brain maps: structure of the rat brain

Guillery, R. W. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90187-q · Cited by 1,669

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157

Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1

Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987) · Science · doi:10.1126/science.2443979 · Cited by 1,151

Effects of Orexins on the Hypothalamic‐Pituitary‐Adrenal System

Jászberényi, M., Bujdosó, E., Pataki, I., & Telegdy, G. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00572.x · Cited by 175

Integrated Analysis of the Cerebrospinal Fluid Peptidome and Proteome

Zougman, A., Pilch, B., Podtelejnikov, A. V., Kiehntopf, M., Schnabel, C., Kumar, C., & Mann, M. (2007) · Journal of Proteome Research · doi:10.1021/pr070501k · Cited by 178

Orexin-A expression in human peripheral tissues

Nakabayashi, M., Suzuki, T., Takahashi, K., Totsune, K., Muramatsu, Y., Kaneko, C., Date, F., Takeyama, J., Darnel, A. D., Moriya, T., et al. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00206-5 · Cited by 174

Orexin Receptor Type-1 Couples Exclusively to Pertussis Toxin-Insensitive G-Proteins, While Orexin Receptor Type-2 Couples to Both Pertussis Toxin-Sensitive and -Insensitive G-Proteins

Zhu, Y. F., Miwa, Y., Yamanaka, A., Yada, T., Shibahara, M., Abe, Y., Sakurai, T., & Goto, K. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.92.259 · Cited by 173

The Orexin OX1 Receptor Activates a Novel Ca2+ Influx Pathway Necessary for Coupling to Phospholipase C

Lund, P.-E., Shariatmadari, R., Uustare, A., Detheux, M., Parmentier, M., Kukkonen, J. P., & Åkerman, K. E. O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002603200 · Cited by 173

Tobacco addiction and the dysregulation of brain stress systems

Bruijnzeel, A. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.015 · Cited by 181

The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function

Ferguson, A. V., & Samson, W. K. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(03)00028-1 · Cited by 172

A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?

James, M. H., Mahler, S. V., Moorman, D. E., & Aston‐Jones, G. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_57 · Cited by 175

The mouse: genetics meets behaviour

Bućan, M., & Abel, T. G. (2002) · Nature Reviews Genetics · doi:10.1038/nrg728 · Cited by 173

The Wake-Promoting Hypocretin–Orexin Neurons Are in an Intrinsic State of Membrane Depolarization

Eggermann, E., Bayer, L., Serafin, M., Saint-Mleux, B., Bernheim, L., Machard, D., Jones, B. E., & Mühlethaler, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01557.2003 · Cited by 170

Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro

Antunes, V. R., Brailoiu, G. C., Kwok, E. H., Scruggs, P., & Dun, N. J. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.6.r1801 · Cited by 169

The physiological control of eating: signals, neurons, and networks

Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168

Brain regulation of energy balance and body weight

Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168

Brain structures and receptors involved in alertness

Aston‐Jones, G. (2005) · Sleep Medicine · doi:10.1016/s1389-9457(05)80002-4 · Cited by 168

Exclusive Postsynaptic Action of Hypocretin-Orexin on Sublayer 6b Cortical Neurons

Bayer, L., Serafin, M., Eggermann, E., Saint-Mleux, B., Machard, D., Jones, B. E., & Mühlethaler, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1783-04.2004 · Cited by 168

Hypocretin Levels in Sporadic and Familial Cases of Canine Narcolepsy

Ripley, B. A., Fujiki, N., Okura, M., Mignot, E. J.-M., & Nishino, S. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0389 · Cited by 167

Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids

Karnani, M., Apergis‐Schoute, J., Adamantidis, A., Jensen, L. T., de Lecea, L., Fugger, L. H., & Burdakov, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.027 · Cited by 171

A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors

Wang, H., Qian, T., Zhao, Y., Zhuo, Y., Wu, C., Osakada, T., Chen, P., Chen, Z., Ren, H., Yan, Y., et al. (2023) · Science · doi:10.1126/science.abq8173 · Cited by 166

The brain and brown fat

Contreras, C., González, F., Fernø, J., Diéguez, C., Rahmouni, K., Nogueiras, R., & López, M. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.919727 · Cited by 167

Fatigue in multiple sclerosis – Insights into evaluation and management

Ayache, S. S., & Chalah, M. A. (2017) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2017.02.004 · Cited by 163

Feeding and activity induced by orexin A in the lateral hypothalamus in rats

Kotz, C. M., Teske, J. A., Levine, J. A., & Wang, C. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00346-9 · Cited by 163

Orexins and appetite regulation

Rodgers, R. J., Ishii, Y., Halford, J. C. G., & Blundell, J. E. (2002) · Neuropeptides · doi:10.1016/s0143-4179(02)00085-9 · Cited by 163

Discovery of a Novel Superpotent and Selective Melanocortin-4 Receptor Antagonist (HS024): Evaluation in Vitro and in Vivo

Kask, A., Mutulis, F., Muceniece, R., Pähkla, R., Mutule, I., Wikberg, J. E. S., Rägo, L., & Schiöth, H. B. (1998) · Endocrinology · doi:10.1210/endo.139.12.6352 · Cited by 163

Effects of Suvorexant, an Orexin Receptor Antagonist, on Sleep Parameters as Measured by Polysomnography in Healthy Men

Sun, H., Kennedy, W. P., Wilbraham, D., Lewis, N. M., Calder, N. A., Li, X., Ma, J., Yee, K. L., Ermlich, S. J., Mangin, E. C., et al. (2013) · SLEEP · doi:10.5665/sleep.2386 · Cited by 162

International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin Receptor Function, Nomenclature and Pharmacology

Gotter, A. L., Webber, A. L., Coleman, P. J., Renger, J. J., & Winrow, C. J. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005546 · Cited by 165

Effects of arousal‐ and feeding‐related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat

Korotkova, T. M., Brown, R. E., Sergeeva, O. A., Ponomarenko, A. A., & Haas, H. L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04792.x · Cited by 162

Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior

Suzuki, M., Beuckmann, C. T., Shikata, K., Ogura, H., & Sawai, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.002 · Cited by 161

Hypocretins (orexins) and sleep–wake disorders

Baumann, C. R., & Bassetti, C. L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70196-4 · Cited by 164

Effects of Saporin-Induced Lesions of Three Arousal Populations on Daily Levels of Sleep and Wake

Blanco‐Centurion, C., Gerashchenko, D., & Shiromani, P. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3217-07.2007 · Cited by 163

Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy

Schwartz, S., Ponz, A., Poryazova, R., Werth, E., Boesiger, P., Khatami, R., & Bassetti, C. L. (2007) · Brain · doi:10.1093/brain/awm292 · Cited by 164

New Insights into the Neurobiology of Restless Legs Syndrome

Ferré, S., García-Borreguero, D., Allen, R. P., & Earley, C. J. (2018) · The Neuroscientist · doi:10.1177/1073858418791763 · Cited by 169

Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?

Ballante, F., Kooistra, A. J., Kampen, S., de Graaf, C., & Carlsson, J. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000246 · Cited by 169

Eating Elicited by Orexin-A, But Not Melanin-Concentrating Hormone, Is Opioid Mediated

Clegg, D. J., Air, E. L., Woods, S. C., & Seeley, R. J. (2002) · Endocrinology · doi:10.1210/endo.143.8.8977 · Cited by 160

Modulation of Cortical Activation and Behavioral Arousal by Cholinergic and Orexinergic Systems

Jones, B. E. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.026 · Cited by 159

Orexin Excites GABAergic Neurons of the Arcuate Nucleus by Activating the Sodium—Calcium Exchanger

Burdakov, D., Liss, B., & Ashcroft, F. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04951.2003 · Cited by 159

The 5-HT2C receptor and antipsychoticinduced weight gain – mechanisms and genetics

Reynolds, G. P., Hill, M., & Kirk, S. L. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066040 · Cited by 159

Photoperiod regulates arcuate nucleus POMC, AGRP, and leptin receptor mRNA in Siberian hamster hypothalamus

Mercer, J. G., Moar, K. M., Ross, A., Hoggard, N., & Morgan, P. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.1.r271 · Cited by 163

Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders

Xu, T., Yang, Y., Ward, R. J., Gao, L., & Liu, Y. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.025 · Cited by 162

Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP‐expressing locus coeruleus

van den Pol, A. N., Ghosh, P. K., Liu, R., Li, Y., Aghajanian, G. K., & Gao, X. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.017426 · Cited by 158

Hypocretins Regulate the Anxiogenic-Like Effects of Nicotine and Induce Reinstatement of Nicotine-Seeking Behavior

Plaza‐Zabala, A., Martín‐García, E., de Lecea, L., Maldonado, R. J., & Berrendero, F. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5724-09.2010 · Cited by 159

Orexin (hypocretin) innervation of the paraventricular nucleus of the thalamus

Kirouac, G. J., Parsons, M. P., & Li, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.08.035 · Cited by 157

CSF hypocretin-1 assessment in sleep and neurological disorders

Bourgin, P., Zeitzer, J. M., & Mignot, E. J.-M. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70140-6 · Cited by 161

Transgenic Approach to the Study of Body Weight Regulation

Inui, A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01435-2 · Cited by 159

Feelings about food: the ventral tegmental area in food reward and emotional eating

Meye, F. J., & Adan, R. A. H. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.11.003 · Cited by 164

Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

Shoblock, J. R., Welty, N., Aluisio, L. E., Fraser, I. C., Motley, S. T., Morton, K. L., Palmer, J. A., Bonaventure, P., Carruthers, N. I., Lovenberg, T. W., et al. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2127-x · Cited by 157

Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding

Alcantara, I. C., Tapia, A. P. M., Aponte, Y., & Krashes, M. J. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00611-y · Cited by 155

Stress, Arousal, and Sleep

Sanford, L. D., Suchecki, D., & Meerlo, P. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_314 · Cited by 159

The integrated brain network that controls respiration

Krohn, F., Novello, M., van der Giessen, R. S., Zeeuw, C. I. D., Pel, J. J. M., & Bosman, L. W. J. (2023) · eLife · doi:10.7554/elife.83654 · Cited by 164

Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats

Piccoli, L., Bonaventura, M. V. M. D., Cifani, C., Costantini, V. J. A., Massagrande, M., Montanari, D., Martinelli, P., Antolini, M., Ciccocioppo, R., Massi, M., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.48 · Cited by 157

Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking

Shalev, U., Erb, S. M., & Shaham, Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.028 · Cited by 161

Free radicals and male reproduction.

Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154

Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons

Sakamoto, F., Yamada, S., & Ueta, Y. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2003.12.014 · Cited by 160

Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats

Jain, M. R., Horváth, T. L., Kalra, P. S., & Kalra, S. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00102-0 · Cited by 154

Hypocretin/Orexin Neurons Contribute to Hippocampus-Dependent Social Memory and Synaptic Plasticity in Mice

Yang, L., Zou, B., Xiong, X., Pascual, C., Xie, J., Malik, A., Xie, J., Sakurai, T., & Xie, X. (. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3200-12.2013 · Cited by 153

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

Winrow, C. J., & Renger, J. J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12261 · Cited by 153

Neuronal control of energy homeostasis

Gao, Q., & Horváth, T. L. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.063 · Cited by 160

Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and γ‐aminobutyric acid neurons

Balcita‐Pedicino, J. J., & Sesack, S. R. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21420 · Cited by 150

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells

Merkle, F. T., Maroof, A. M., Wataya, T., Sasai, Y., Studer, L., Eggan, K. C., & Schier, A. F. (2015) · Development · doi:10.1242/dev.117978 · Cited by 151

Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution

Semmens, D. C., Mirabeau, O., Moghul, I., Pancholi, M. R., Wurm, Y., & Elphick, M. R. (2016) · Open Biology · doi:10.1098/rsob.150224 · Cited by 169

Orexins, Orexigenic Hypothalamic Neuropeptides, Suppress the Pulsatile Secretion of Luteinizing Hormone in Ovariectomized Female Rats

Tamura, T., Irahara, M., Tezuka, M., Kiyokawa, M., & Aono, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1573 · Cited by 152

Sleep Neurobiology for the Clinician

(2004) · Sleep · doi:10.1093/sleep/27.4.811 · Cited by 151

Neuroanatomy and neurochemistry of sleep

Stenberg, D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6530-3 · Cited by 151

Ghrelin-induced feeding is dependent on nitric oxide

Gaskin, F. S., Farr, S. A., Banks, W. A., Kumar, V. B., & Morley, J. E. (2003) · Peptides · doi:10.1016/s0196-9781(03)00160-8 · Cited by 153

Hypocretin/orexin, sleep and narcolepsy

Hungs, M., & Mignot, E. J.-M. (2001) · BioEssays · doi:10.1002/bies.1058 · Cited by 151

Central Nervous System Regulation of Brown Adipose Tissue

Morrison, S. F., & Madden, C. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140013 · Cited by 161

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148

Deep brain stimulation in the treatment of obesity

Halpern, C. H., Wolf, J. A., Bale, T. L., Stunkard, A. J., Danish, S. F., Grossman, M., Jaggi, J. L., Grady, M. S., & Baltuch, G. H. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/10/0625 · Cited by 154

Pattern of Hypocretin (Orexin) Soma and Axon Loss, and Gliosis, in Human Narcolepsy

Thannickal, T. C., Siegel, J. M., Nienhuis, R., & Moore, R. Y. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00033.x · Cited by 150

Selective Action of Orexin (Hypocretin) on Nonspecific Thalamocortical Projection Neurons

Bayer, L., Eggermann, E., Saint-Mleux, B., Machard, D., Jones, B. E., Mühlethaler, M., & Serafin, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07835.2002 · Cited by 150

Down regulation of the prepro-orexin gene expression in genetically obese mice

Yamamoto, Y., Ueta, Y., Date, Y., Nakazato, M., Hara, Y., Serino, R., Nomura, M. J., Shibuya, I., Matsukura, S., & Yamashita, H. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00320-9 · Cited by 151

Comparison of melanin-concentrating hormone and hypocretin/orexin mRNA expression patterns in a new parceling scheme of the lateral hypothalamic zone

Swanson, L. W., Sanchez‐Watts, G., & Watts, A. G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.066 · Cited by 149

Categorically Distinct Acute Stressors Elicit Dissimilar Transcriptional Profiles in the Paraventricular Nucleus of the Hypothalamus

Reyes, T. M., Walker, J. R., DeCino, C., Hogenesch, J. B., & Sawchenko, P. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05607.2003 · Cited by 149

The posterior hypothalamic area: chemoarchitecture and afferent connections

Abrahamson, E. E., & Moore, R. Y. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03015-8 · Cited by 149

Hypothalamic control of energy metabolism via the autonomic nervous system

Kalsbeek, A., Bruinstroop, E., Yi, C., Klieverik, L. P., la Fleur, S. E., & Fliers, E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05800.x · Cited by 152

Control of food intake via leptin receptors in the hypothalamus

Meister, B. (2000) · Vitamins and hormones · doi:10.1016/s0083-6729(00)59010-4 · Cited by 156

Widespread Distribution of Orexin in Rat Brain and Its Regulation upon Fasting

Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Yanagisawa, M., & Matsukura, S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0362 · Cited by 148

Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation

Beuckmann, C. T., & Yanagisawa, M. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0322-x · Cited by 148

Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats

Greco, M. A., & Shiromani, P. J. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00039-0 · Cited by 147

Molecular Mechanisms of Cancer-Induced Sleep Disruption

Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 149

Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-B

Volkoff, H., Bjorklund, J. M., & Peter, R. E. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02052-1 · Cited by 146

Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement

Wu, M.-F., John, J., Maidment, N. T., Lam, H. A., & Siegel, J. M. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00207.2002 · Cited by 146

Fasting increases and satiation decreases olfactory detection for a neutral odor in rats

Aimé, P., Duchamp‐Viret, P., Chaput, M. A., Savigner, A., Mahfouz, M., & Julliard, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.012 · Cited by 146

Treatment of Narcolepsy and other Hypersomnias of Central Origin

Wise, M. S., Arand, D. L., Auger, R. R., Brooks, S. N., & Watson, N. F. (2007) · SLEEP · doi:10.1093/sleep/30.12.1712 · Cited by 145

Orexigenic Peptides and Alcohol Intake: Differential Effects of Orexin, Galanin, and Ghrelin

Schneider, E. R., Rada, P. V., Darby, R. D., LEIBOWITZ, S. F., & Hoebel, B. G. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00510.x · Cited by 148

Adverse effects of nutritional programming during prenatal and early postnatal life, some aspects of regulation and potential prevention and treatments.

Guilloteau, P., Zabielski, R., Hammon, H. M., & Metges, C. C. (2009) · PubMed · Cited by 148

Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides

Ma, J., Diedrich, J. K., Jungreis, I., Donaldson, C. J., Vaughan, J. M., Kellis, M., Yates, J. R., & Saghatelian, A. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00191 · Cited by 145

History of the Development of Sleep Medicine in the United States

Shepard, J., Buysse, D. J., Chesson, A. L., Dement, W. C., Goldberg, R., Guilleminault, C., Harris, C., Iber, C., Mignot, E. J.-M., Mitler, M. M., et al. (2005) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26298 · Cited by 150

Prefrontal Cortex–Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal

Huang, H., Ghosh, P. K., & van den Pol, A. N. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00927.2005 · Cited by 145

Orexin Mediates the Expression of Precipitated Morphine Withdrawal and Concurrent Activation of the Nucleus Accumbens Shell

Sharf, R., Sarhan, M., & Dileone, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.006 · Cited by 146

Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats

Reppucci, C. J., & Petrovich, G. D. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1081-0 · Cited by 155

Orexin A Stimulates Cortisol Secretion from Human Adrenocortical Cells through Activation of the Adenylate Cyclase-Dependent Signaling Cascade

Mazzocchi, G., Malendowicz, L. K., Gottardo, L., Aragona, F., & Nussdorfer, G. G. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7233 · Cited by 147

Stress and Arousal: The Corticotrophin-Releasing Factor/Hypocretin Circuitry

Winsky‐Sommerer, R., Boutrel, B., & de Lecea, L. (2005) · Molecular Neurobiology · doi:10.1385/mn:32:3:285 · Cited by 144

Pharmacological Treatment of Obesity: Therapeutic Strategies

Kordik, C. P., & Reitz, A. B. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980521l · Cited by 145

Fos Activation of Selective Afferents to Ventral Tegmental Area during Cue-Induced Reinstatement of Cocaine Seeking in Rats

Mahler, S. V., & Aston‐Jones, G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2277-12.2012 · Cited by 150

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Yin, J., Babaoglu, K., Brautigam, C. A., Clark, L. D., Shao, Z., Scheuermann, T. H., Harrell, C. M., Gotter, A. L., Roecker, A. J., Winrow, C. J., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3183 · Cited by 148

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking

James, M. H., Charnley, J. L., Levi, E. M., Jones, E., Yeoh, J. W., Smith, D. W., & Dayas, C. V. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000423 · Cited by 145

Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction?

Gundlach, A. L. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01433-4 · Cited by 142

Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors

Civelli, O. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01763-x · Cited by 143

Differential Target-Dependent Actions of Coexpressed Inhibitory Dynorphin and Excitatory Hypocretin/Orexin Neuropeptides

Li, Y., & van den Pol, A. N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3380-06.2006 · Cited by 141

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

Willie, J. T., Sinton, C. M., Maratos–Flier, E., & Yanagisawa, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.048 · Cited by 141

Neurons containing hypocretin (orexin) project to multiple neuronal systems

Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466

Co-localization of hypocretin-1 and hypocretin-2 in the cat hypothalamus and brainstem

Zhang, J.-H., Sampogna, S. L., Morales, F. R., & Chase, M. H. (2002) · Peptides · doi:10.1016/s0196-9781(02)00084-0 · Cited by 37

Presynaptic and Postsynaptic Actions and Modulation of Neuroendocrine Neurons by a New Hypothalamic Peptide, Hypocretin/Orexin

van den Pol, A. N., Gao, X., Obrietan, K. H., Kilduff, T. S., & Belousov, A. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07962.1998 · Cited by 552

Interaction of the hypocretins with neurotransmitters in the nucleus accumbens

Martin, G. E., Fabre, V., Siggins, G. R., & de Lecea, L. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00354-8 · Cited by 91

THE NE SYSTEM AS A TARGET FOR HYPOCRETIN NEURONS: Implications for regulation of arousal

Aston‐Jones, G., Card, J. P., Zhu, Y., González, M. M. C., & Haggerty, E. (2013)