Brain regulation of energy balance and body weight

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

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Obesity is associated with hypothalamic injury in rodents and humans.

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

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Anatomy and regulation of the central melanocortin system

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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

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Leptin-regulated endocannabinoids are involved in maintaining food intake

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Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

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Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

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The control of firing pattern in nigral dopamine neurons: burst firing

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A role for lateral hypothalamic orexin neurons in reward seeking

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Hypothalamic CART is a new anorectic peptide regulated by leptin

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Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

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Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

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AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

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Mice lacking melanin-concentrating hormone are hypophagic and lean

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NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

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Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

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Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

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Insulin receptors are widely distributed in the central nervous system of the rat

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

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Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

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Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

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Deconstruction of a neural circuit for hunger

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Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding

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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

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Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

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Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

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Diabetes, Obesity, and the Brain

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Adaptive thermogenesis in adipocytes: Is beige the new brown?

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Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

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BDNF regulates eating behavior and locomotor activity in mice

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Agouti-related peptide–expressing neurons are mandatory for feeding

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Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

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βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

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Reward mechanisms in obesity: new insights and future directions

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Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

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UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

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Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance

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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

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Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

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Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

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Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

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Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

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Leptin Regulation of the Mesoaccumbens Dopamine Pathway

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Large, rare chromosomal deletions associated with severe early-onset obesity

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Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

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BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

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