Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and γ‐aminobutyric acid neurons
Abstract
Cells in the ventral tegmental area (VTA) facilitate motivated behaviors, and the activity of VTA neurons is regulated by dense projections from the lateral hypothalamic area (LHA). Orexin (Orx) neurons in the lateral and perifornical hypothalamus play important roles in arousal, feeding, and energy metabolism. Orx cells contribute substantially to the LHA projection to the rat midbrain. However, the morphological features of Orx fibers in the VTA and whether they synapse onto dopamine (DA) or γ‐aminobutyric acid (GABA) neurons have not yet been investigated. We utilized immunoperoxidase and immunogold‐silver staining to examine the morphological features and synaptic incidence of Orx‐labeled axons in the VTA. We then combined immunoperoxidase labeling for Orx with immunogold‐silver labeling for GABA or for tyrosine hydroxylase (TH) in DA neurons. Electron microscopic analysis revealed that most Orx‐labeled axons in the VTA were passing fibers. The less common Orx varicosities were occasionally apposed to TH‐ or GABA‐labeled dendrites without synapsing. Only a small proportion of Orx‐positive axons synapsed onto dendrites or soma. The synapses included both asymmetric and symmetric types and targeted TH‐ and GABA‐labeled profiles with equal frequency. These findings suggest that most Orx fibers in the VTA are axons passing to caudal brainstem structures. However, Orx does mediate some direct synaptic influence on VTA DA and GABA neurons. Additional nonsynaptic effects are suggested by the presence of numerous dense‐cored vesicles. These studies have important implications for understanding the mechanisms whereby Orx can alter behavior through regulating VTA DA and GABA cell activity. J. Comp. Neurol. 503:668–684, 2007. © 2007 Wiley‐Liss, Inc.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The nucleus accumbens shell is part of a neural loop including the lateral hypothalamus and the ventral tegmental area, with orexin neurons playing a key role.
“The nucleus accumbens shell is thereby part of a neural loop including the lateral hypothalamus and the ventral tegmental area, with orexin neurons playing a key role ([7](#B7), [22](#B22), [77](#B77), [98](#B98), [115](#B115), [125](#B125), [175](#B175), [199](#B199)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [7]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · see citing works
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758 · see citing works
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659 · see citing works
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works
(1991) · Medical Entomology and Zoology · Cited by 1,512 · see citing works
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401 · see citing works
A role for lateral hypothalamic orexin neurons in reward seeking
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311 · see citing works
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J. J., Leslie, R. A., Patel, S., Evans, M. L., Wattam, T. A., Holmes, S., Benham, C. D., Taylor, S. G., Routledge, C., Hemmati, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10911 · Cited by 1,234 · see citing works
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075 · see citing works
Distribution of orexin neurons in the adult rat brain
Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M., & Goto, K. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01336-0 · Cited by 1,070 · see citing works
Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050 · see citing works
Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880 · see citing works
Self-citationBehavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
Mileykovskiy, B. Y., Kiyashchenko, L. I., & Siegel, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.035 · Cited by 841 · see citing works
Carlin, R. K., Grab, D. J., Cohen, R. S., & Siekevitz, P. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.86.3.831 · Cited by 788 · see citing works
To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness
Willie, J. T., Chemelli, R. M., Sinton, C. M., & Yanagisawa, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.429 · Cited by 768 · see citing works
Borgland, S. L., Taha, S. A., Sarti, F., Fields, H. L., & Bonci, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.016 · Cited by 718 · see citing works
Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins
Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L., & Brown, R. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00007.2003 · Cited by 583 · see citing works
Phillipson, O. T. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870108 · Cited by 553 · see citing works
van den Pol, A. N., Gao, X., Obrietan, K. H., Kilduff, T. S., & Belousov, A. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07962.1998 · Cited by 552 · see citing works
Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord
van den Pol, A. N. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03171.1999 · Cited by 524 · see citing works
Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2761-05.2006 · Cited by 516 · see citing works
An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat
Saper, C. B., Swanson, L. W., & Cowan, W. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901830402 · Cited by 509 · see citing works
Is the short-latency dopamine response too short to signal reward error?
Redgrave, P., Prescott, T. J., & Gurney, K. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01373-3 · Cited by 506 · see citing works
Horváth, T. L., Diano, S., & van den Pol, A. N. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01072.1999 · Cited by 504 · see citing works
Fadel, J. R., & Deutch, A. Y. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00017-9 · Cited by 503 · see citing works
Li, Y., Gao, X., Sakurai, T., & van den Pol, A. N. (2002) · Neuron · doi:10.1016/s0896-6273(02)01132-7 · Cited by 476 · see citing works
Chan, J., Aoki, C. J., & Pickel, V. M. (1990) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(90)90015-8 · Cited by 447 · see citing works
Orexin (Hypocretin) Neurons Contain Dynorphin
Chou, T. C., Lee, C. E., Lü, J., Elmquist, J. K., Hara, J., Willie, J. T., Beuckmann, C. T., Chemelli, R. M., Sakurai, T., Yanagisawa, M., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-j0003.2001 · Cited by 430 · see citing works
The hypocretins: Setting the arousal threshold
Sutcliffe, J. G., & de Lecea, L. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn808 · Cited by 416 · see citing works
The lateral hypothalamic area revisited: Ingestive behavior
Bernardis, L. L., & Bellinger, L. L. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00015-1 · Cited by 402 · see citing works
Behavioral State Instability in Orexin Knock-Out Mice
Mochizuki, T., Crocker, A. J., McCormack, S. L., Yanagisawa, M., Sakurai, T., & Scammell, T. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0586-04.2004 · Cited by 397 · see citing works
Liu, R.-J., van den Pol, A. N., & Aghajanian, G. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09453.2002 · Cited by 392 · see citing works
Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions
Geisler, S., & Zahm, D. S. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20668 · Cited by 379 · see citing works
Glutamatergic neurons are present in the rat ventral tegmental area
Yamaguchi, T., Sheen, W., & Morales, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05263.x · Cited by 367 · see citing works
Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens
Hernandez, L., & Hoebel, B. G. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90324-1 · Cited by 355 · see citing works
Baldo, B. A., Daniel, R. A., Berridge, C. W., & Kelley, A. E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10783 · Cited by 346 · see citing works
GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain
Bockstaele, E. J. V., & Pickel, V. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00334-m · Cited by 328 · see citing works
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
Crocker, A., España, R. A., Papadopoulou, M., Saper, C. B., Faraco, J., Sakurai, T., Honda, M., Mignot, E., & Scammell, T. E. (2005) · Neurology · doi:10.1212/01.wnl.0000168173.71940.ab · Cited by 301 · see citing works
Lu, X., Bagnol, D., Burke, S., Akil, H., & Watson, S. J. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1584 · Cited by 299 · see citing works
Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor
Yamanaka, A., Tsujino, N., Funahashi, H., Honda, K., Guan, J., Wang, Q.-P., Tominaga, M., Goto, K., Shioda, S., & Sakurai, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6318 · Cited by 297 · see citing works
Miller, J. D., Farber, J., Gatz, P., Roffwarg, H. P., & German, D. C. (1983) · Brain Research · doi:10.1016/0006-8993(83)91101-0 · Cited by 269 · see citing works
Protein distribution of the orexin-2 receptor in the rat central nervous system
Cluderay, J. E., Harrison, D. C., & Hervieu, G. J. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00357-3 · Cited by 264 · see citing works
Efferent connections of the lateral hypothalamic area of the rat: An autoradiographic investigation
Berk, M. L., & Finkelstein, J. A. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90009-0 · Cited by 260 · see citing works
Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area
Omelchenko, N., & Sesack, S. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20417 · Cited by 252 · see citing works
Self-citationHypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2
Rosin, D. L., Weston, M. C., Sevigny, C. P., Stornetta, R. L., & Guyenet, P. G. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10860 · Cited by 252 · see citing works
Hypocretin (OREXIN): Role in Normal Behavior and Neuropathology
Siegel, J. M. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.141545 · Cited by 247 · see citing works
Distribution of vesicular glutamate transporter mRNA in rat hypothalamus
Ziegler, D. R., Cullinan, W. E., & Herman, J. P. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10257 · Cited by 241 · see citing works
Umbriaco, D., Watkins, K. C., Descarries, L., Cozzari, C., & Hartman, B. K. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480304 · Cited by 237 · see citing works
Kawano, M., Kawasaki, A., Sakata‐Haga, H., Fukui, Y., Kawano, H., Nogami, H., & Hisano, S. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21054 · Cited by 230 · see citing works
Sesack, S. R., Snyder, C. L., & Lewis, D. A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903630208 · Cited by 226 · see citing works
Self-citationLateral hypothalamic neuropeptides in reward and drug addiction
Dileone, R., Georgescu, D., & Nestler, E. J. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00408-9 · Cited by 220 · see citing works
Cutler, D. J., Morris, R., Sheridhar, V., Wattam, T. A., Holmes, S., Patel, S., Arch, J. R. S., Wilson, S., Buckingham, R. E., Evans, M. L., et al. (1999) · Peptides · doi:10.1016/s0196-9781(99)00157-6 · Cited by 217 · see citing works
Torrealba, F., Yanagisawa, M., & Saper, C. B. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00238-0 · Cited by 195 · see citing works
Exocytosis from Neuronal Large Dense-Cored Vesicles
Thureson‐Klein, Å., & Klein, R. L. (1990) · International review of cytology · doi:10.1016/s0074-7696(08)60659-2 · Cited by 193 · see citing works
Vittoz, N. M., & Berridge, C. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300807 · Cited by 189 · see citing works
Reduced food anticipatory activity in genetically orexin (hypocretin) neuron‐ablated mice
Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03749.x · Cited by 184 · see citing works
Synaptic remodeling of serotonin axon terminals in rat agranular cerebellum
Beaudet, A., & Sotelo, C. (1981) · Brain Research · doi:10.1016/0006-8993(81)90534-5 · Cited by 168 · see citing works
Aston‐Jones, G., Zhu, Y., & Card, J. P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5339-03.2004 · Cited by 167 · see citing works
Korotkova, T. M., Brown, R. E., Sergeeva, O. A., Ponomarenko, A. A., & Haas, H. L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04792.x · Cited by 162 · see citing works
Trulson, M. E., & Preussler, D. W. (1984) · Experimental Neurology · doi:10.1016/s0014-4886(84)90105-5 · Cited by 162 · see citing works
Swanson, L. W., Sanchez‐Watts, G., & Watts, A. G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.066 · Cited by 149 · see citing works
Uramura, K., Funahashi, H., Muroya, S., Shioda, S., Takigawa, M., & Yada, T. (2001) · Neuroreport · doi:10.1097/00001756-200107030-00024 · Cited by 141 · see citing works
Laviolette, S. R., & van der Kooy, D. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01458.x · Cited by 140 · see citing works
Hypocretin/Orexin Innervation and Excitation of Identified Septohippocampal Cholinergic Neurons
Wu, M., Záborszky, L., Hajszán, T., van den Pol, A. N., & Alreja, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5364-03.2004 · Cited by 140 · see citing works
Zheng, H., Patterson, L. M., & Berthoud, H. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20515 · Cited by 137 · see citing works
Lateral Hypothalamic Serotonin Inhibits Nucleus Accumbens Dopamine: Implications for Sexual Satiety
Lorrain, D. S., Riolo, J. V., Matuszewich, L., & Hull, E. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07648.1999 · Cited by 129 · see citing works
Dallvechia‐Adams, S., Kuhar, M. J., & Smith, Y. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10268 · Cited by 125 · see citing works
Organization of thalamostriatal terminals from the ventral motor nuclei in the macaque
McFarland, N. R., & Haber, S. N. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000108)429:2 · Cited by 109 · see citing works
Lee, R., Steffensen, S. C., & Henriksen, S. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01757.2001 · Cited by 109 · see citing works
Sesack, S. R., & Pickel, V. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01335.1992 · Cited by 102 · see citing works
Self-citationKorotkova, T. M., Eriksson, K. S., Haas, H. L., & Brown, R. E. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00323-8 · Cited by 102 · see citing works
Glial modulation of synaptic transmission: Insights from the supraoptic nucleus of the hypothalamus
Oliet, S. H. R., Piet, R., Poulain, D. A., & Theodosis, D. T. (2004) · Glia · doi:10.1002/glia.20032 · Cited by 98 · see citing works
Huesa, G., van den Pol, A. N., & Finger, T. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20610 · Cited by 94 · see citing works
Orexin: a link between energy homeostasis and adaptive behaviour.
Sakurai, T. (2003) · PubMed · doi:10.1097/01.mco.0000078995.96795.91 · Cited by 93 · see citing works
Mintz, E. M., van den Pol, A. N., Casano, A. A., & Albers, H. E. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00111-9 · Cited by 89 · see citing works
Comparison of methods for the estimation of the thickness of ultrathin tissue sections
de Groot, D. (1988) · Journal of Microscopy · doi:10.1111/j.1365-2818.1988.tb04610.x · Cited by 84 · see citing works
Regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation
Thorpe, A. J., Mullett, M. A., Wang, C., & Kotz, C. M. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00344.2002 · Cited by 77 · see citing works
Zahm, D. S., Grosu, S., Williams, E. A., Qin, S., & Bérod, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00118-x · Cited by 68 · see citing works
Responses of ventral tegmental area GABA neurons to brain stimulation reward
Steffensen, S. C., Lee, R., Stobbs, S. H., & Henriksen, S. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02581-1 · Cited by 68 · see citing works
Different Neuronal Phenotypes in the Lateral Hypothalamus and Their Role in Sleep and Wakefulness
Gerashchenko, D., & Shiromani, P. J. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:1:41 · Cited by 67 · see citing works
Pickel, V. M., Chan, J., & Sesack, S. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90693-h · Cited by 63 · see citing works
Self-citationWaselus, M., Valentino, R. J., & Bockstaele, E. J. V. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20360 · Cited by 63 · see citing works
Metabolic state signalling through central hypocretin/orexin neurons
Burdakov, D., & Alexopoulos, H. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00380.x · Cited by 57 · see citing works
Dynamic neuronal–glial interactions: an overview 20 years later
Hatton, G. I. (2004) · Peptides · doi:10.1016/j.peptides.2003.12.001 · Cited by 57 · see citing works
Chou, Y.-H., Halldin, C., & Farde, L. (2000) · Synapse · doi:10.1002/1098-2396(200011)38:2 · Cited by 57 · see citing works
Veznedaroglu, E., & Milner, T. A. (1992) · Microscopy Research and Technique · doi:10.1002/jemt.1070230110 · Cited by 52 · see citing works
Orexin, drugs and motivated behaviors
Scammell, T. E., & Saper, C. B. (2005) · Nature Neuroscience · doi:10.1038/nn1005-1286 · Cited by 49 · see citing works
Expression and distribution of two isoforms of tyrosine hydroxylase in macaque monkey brain
Lewis, D. A., Melchitzky, D. S., & Haycock, J. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)91360-9 · Cited by 33 · see citing works
Villalobos, J., & Ferssiwi, A. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90346-6 · Cited by 30 · see citing works
Orexin: a gatekeeper of addiction
Carr, D., & Kalivas, P. W. (2006) · Nature Medicine · doi:10.1038/nm0306-274 · Cited by 26 · see citing works
Electron microscopic examination of the orexin immunoreactivity in the dorsal raphe nucleus
Wang, Q., Guan, J., Matsuoka, T., Hirayana, Y., & Shioda, S. (2003) · Peptides · doi:10.1016/s0196-9781(03)00158-x · Cited by 22 · see citing works
Guan, J., Wang, Q., & Shioda, S. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03257-8 · Cited by 20 · see citing works
Lu, W., Marinelli, M., Xu, D.-S., Worley, P. F., & Wolf, M. E. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02036.x · Cited by 17 · see citing works
Characterization of orexin A immunoreactivity in the rat area postrema
Guan, J., Wang, Q., Kageyama, H., Kita, T., Takenoya, F., Hori, T., & Shioda, S. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.01.008 · Cited by 9 · see citing works
Horvath (1999) · doi:10.1002/(sici)1096-9861(19991213)415:2
Flagged first, then by citations
1 of the 101 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works
Self-citationOrexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
Tsujino, N., & Sakurai, T. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001321 · Cited by 479 · see citing works
The role of orexin in motivated behaviours
Sakurai, T. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3837 · Cited by 466 · see citing works
Afferents to the GABAergic tail of the ventral tegmental area in the rat
Kaufling, J., Veinante, P., Pawlowski, S. A., Freund‐Mercier, M., & Barrot, M. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21983 · Cited by 347 · see citing works
Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers
Borgland, S. L., Chang, S., Bowers, M. S., Thompson, J. L., Vittoz, N. M., Floresco, S., Chou, J., Chen, B. T., & Bonci, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6096-08.2009 · Cited by 341 · see citing works
Food reward, hyperphagia, and obesity
Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275 · see citing works
Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour
Bonnavion, P., Mickelsen, L. E., Fujita, A., de Lecea, L., & Jackson, A. C. (2016) · The Journal of Physiology · doi:10.1113/jp271946 · Cited by 271 · see citing works
Role of orexin in modulating arousal, feeding, and motivation
Tsujino, N., & Sakurai, T. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00028 · Cited by 259 · see citing works
Berthoud, H.-R., & Münzberg, H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.051 · Cited by 248 · see citing works
Zheng, H., Patterson, L. M., & Berthoud, H.-R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3542-07.2007 · Cited by 248 · see citing works
The hypocretins/orexins: integrators of multiple physiological functions
Li, J., Hu, Z., & de Lecea, L. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12415 · Cited by 246 · see citing works
Lessons in exercise neurobiology: the case of endorphins.
Dishman, R. K., & O'Connor, P. J. (2009) · Mental health and physical activity · doi:10.1016/j.mhpa.2009.01.002 · Cited by 243 · see citing works
Balcita‐Pedicino, J. J., Omelchenko, N., Bell, R., & Sesack, S. R. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22561 · Cited by 236 · see citing works
Self-citationMultiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works
Orexin/hypocretin role in reward: implications for opioid and other addictions
Baimel, C., Bartlett, S. E., Chiou, L., Lawrence, A. J., Muschamp, J. W., Patkar, O. L., Tung, L.-W., & Borgland, S. L. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12639 · Cited by 180 · see citing works
An update on the connections of the ventral mesencephalic dopaminergic complex
Yetnikoff, L., Lavezzi, H. N., Reichard, R. A., & Zahm, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.010 · Cited by 172 · see citing works
A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?
James, M. H., Mahler, S. V., Moorman, D. E., & Aston‐Jones, G. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_57 · Cited by 171 · see citing works
Shin, A. C., Zheng, H., & Berthoud, H. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.010 · Cited by 148 · see citing works
Sharf, R., Sarhan, M., & Dileone, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.006 · Cited by 144 · see citing works
Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons
Borgland, S. L., Storm, E. E., & Bonci, A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06397.x · Cited by 141 · see citing works
James, M. H., Charnley, J. L., Levi, E. M., Jones, E., Yeoh, J. W., Smith, D. W., & Dayas, C. V. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000423 · Cited by 142 · see citing works
Ethanol Action on Dopaminergic Neurons in the Ventral Tegmental Area
Morikawa, H., & Morrisett, R. A. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91008-8 · Cited by 139 · see citing works
Wang, B., You, Z., & Wise, R. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.018 · Cited by 135 · see citing works
Grafe, L. A., & Bhatnagar, S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.003 · Cited by 134 · see citing works
Functional implications of glutamatergic projections to the ventral tegmental area
Geisler, S., & Wise, R. A. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.4-5.227 · Cited by 125 · see citing works
Moorman, D. E., & Aston‐Jones, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2871-10.2010 · Cited by 127 · see citing works
Modulation of taste responsiveness and food preference by obesity and weight loss
Berthoud, H.-R., & Zheng, H. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.04.004 · Cited by 123 · see citing works
Circadian insights into dopamine mechanisms
Mendoza, J., & Challet, É. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.081 · Cited by 124 · see citing works
Mickelsen, L. E., Kolling, F. W., Chimileski, B. R., Fujita, A., Norris, C., Chen, K., Nelson, C. E., & Jackson, A. C. (2017) · eNeuro · doi:10.1523/eneuro.0013-17.2017 · Cited by 119 · see citing works
Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local Microcircuits
Apergis‐Schoute, J., Ιορδανίδου, Π., Faure, C., Jego, S., Schöne, C., Aitta‐aho, T., Adamantidis, A., & Burdakov, D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5269-14.2015 · Cited by 118 · see citing works
A role for hypocretin/orexin in motivation
Thompson, J. L., & Borgland, S. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.09.028 · Cited by 110 · see citing works
Role of orexin/hypocretin in dependence and addiction
Sharf, R., Sarhan, M., & Dileone, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.028 · Cited by 110 · see citing works
Dual-transmitter systems regulating arousal, attention, learning and memory
Ma, S., Hangya, B., Leonard, C. S., Wisden, W., & Gundlach, A. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.009 · Cited by 103 · see citing works
Brown, M. T. C., Henny, P., Bolam, J. P., & Magill, P. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4423-08.2009 · Cited by 106 · see citing works
Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons
Vittoz, N. M., Schmeichel, B. E., & Berridge, C. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06453.x · Cited by 104 · see citing works
Nocjar, C., Zhang, J., Feng, P., & Panksepp, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.033 · Cited by 105 · see citing works
Regulation of the mesolimbic dopamine circuit by feeding peptides
Liu, S., & Borgland, S. L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.046 · Cited by 100 · see citing works
Neurobiology of hyperactivity and reward: Agreeable restlessness in Anorexia Nervosa
Scheurink, A. J. W., Boersma, G. J., Nergårdh, R., & Södersten, P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.016 · Cited by 99 · see citing works
Tyree, S. M., & de Lecea, L. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00050 · Cited by 95 · see citing works
Neurobiology of overeating and obesity: The role of melanocortins and beyond
Pandit, R., de Jong, J. W., Vanderschuren, L. J. M. J., & Adan, R. A. H. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.01.034 · Cited by 92 · see citing works
Henny, P., Brischoux, F., Mainville, L., Stroh, T., & Jones, B. E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.003 · Cited by 77 · see citing works
Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction
Borgland, S. L., Ungless, M. A., & Bonci, A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.068 · Cited by 75 · see citing works
Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity
Parekh, P. K., & McClung, C. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00187 · Cited by 75 · see citing works
Srinivasan, S., Simms, J. A., Nielsen, C. K., Lieske, S. P., Bito‐Onon, J. J., Yi, H. Y., Hopf, F. W., Bonci, A., & Bartlett, S. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044726 · Cited by 73 · see citing works
Orexinergic innervation of the extended amygdala and basal ganglia in the rat
Schmitt, O., Usunoff, K. G., Lazarov, N., Itzev, D. E., Eipert, P., Rolfs, A., & Wree, A. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0343-8 · Cited by 69 · see citing works
Zahm, D. S., Cheng, A. Y., Lee, T. J., Ghobadi, C. W., Schwartz, Z. M., Geisler, S., Parsely, K. P., Gruber, C., & Veh, R. W. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22670 · Cited by 65 · see citing works
Bonci, A., & Borgland, S. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.024 · Cited by 64 · see citing works
Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders
Li, S., Jones, J. R., & de Lecea, L. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-015-0639-0 · Cited by 63 · see citing works
Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery
Berthoud, H., Zheng, H., & Shin, A. C. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06573.x · Cited by 63 · see citing works
Brown, R. M., Kim, A. K., Khoo, S. Y., Kim, J. H., Jupp, B., & Lawrence, A. J. (2015) · Addiction Biology · doi:10.1111/adb.12251 · Cited by 64 · see citing works
Thomas, C. S., Mohammadkhani, A., Rana, M., Qiao, M., Baimel, C., & Borgland, S. L. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01196-y · Cited by 62 · see citing works
Quarta, D., Valerio, E., Hutcheson, D. M., Hédou, G., & Heidbreder, C. A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.08.012 · Cited by 61 · see citing works
Orexin/Hypocretin Based Pharmacotherapies for the Treatment of Addiction: DORA or SORA?
Khoo, S. Y., & Brown, R. M. (2014) · CNS Drugs · doi:10.1007/s40263-014-0179-x · Cited by 60 · see citing works
Goel, M., Mittal, A., Jain, V. R., Bharadwaj, A., Modi, S., Ahuja, G., Jain, A., & Kumar, K. (2024) · Annals of Neurosciences · doi:10.1177/09727531241255492 · Cited by 66 · see citing works
Ventromedial hypothalamus glucose‐inhibited neurones: A role in glucose and energy homeostasis?
Hirschberg, P. R., Sarkar, P., Teegala, S. B., & Routh, V. H. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12773 · Cited by 59 · see citing works
Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone
Katzman, M. A., & Katzman, M. P. (2022) · Brain Sciences · doi:10.3390/brainsci12020150 · Cited by 58 · see citing works
The Hypocretin/Orexin System: Implications for Drug Reward and Relapse
Plaza‐Zabala, A., Maldonado, R. J., & Berrendero, F. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8255-z · Cited by 58 · see citing works
Steiner, M. A., Lecourt, H., & Jenck, F. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000193 · Cited by 56 · see citing works
Li, S., Giardino, W. J., & de Lecea, L. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_58 · Cited by 52 · see citing works
Sadeghi, S., Reisi, Z., Azhdari‐Zarmehri, H., & Haghparast, A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.02.011 · Cited by 51 · see citing works
Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat
Davis, J. F., Choi, D. L., Schurdak, J. D., Krause, E. G., Fitzgerald, M. F., Lipton, J. W., Sakai, R. R., & Benoit, S. C. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.017 · Cited by 49 · see citing works
Rao, Y., Mineur, Y. S., Gan, G., Wang, A. H., Liu, Z., Wu, X., Suyama, S., de Lecea, L., Horváth, T. L., Picciotto, M. R., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.246983 · Cited by 46 · see citing works
Hassani, O. K., Krause, M. R., Mainville, L., Córdova, C. A., & Jones, B. E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3903-15.2016 · Cited by 45 · see citing works
The potential role of the orexin reward system in future treatments for opioid drug abuse
Zarrabian, S., Riahi, E., Karimi, S., Razavi, Y., & Haghparast, A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.023 · Cited by 44 · see citing works
Cannella, N., Kallupi, M., Ruggeri, B., Ciccocioppo, R., & Ubaldi, M. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.09.005 · Cited by 42 · see citing works
The Orexins/Hypocretins and Schizophrenia
Deutch, A. Y., & Bubser, M. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm096 · Cited by 40 · see citing works
Hypocretin modulation of drug-induced synaptic plasticity
Baimel, C., & Borgland, S. L. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00008-2 · Cited by 40 · see citing works
Domínguez, L., Morona, R., Joven, A., González, A., & López, J. M. (2009) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2009.07.007 · Cited by 40 · see citing works
Rorabaugh, J. M., Stratford, J. M., & Zahniser, N. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095019 · Cited by 37 · see citing works
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship
Kim, A. K., Brown, R. M., & Lawrence, A. J. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00078 · Cited by 35 · see citing works
Diversity in the lateral hypothalamic input to the ventral tegmental area
Godfrey, N., & Borgland, S. L. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.014 · Cited by 33 · see citing works
Quarta, D., & Smolders, I. J. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.01.008 · Cited by 34 · see citing works
Matzeu, A., & Martin‐Fardon, R. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.787595 · Cited by 34 · see citing works
Coregulation of sleep-pain physiological interplay by orexin system: An unprecedented review
Ahmadi‐Soleimani, S. M., Mianbandi, V., Azizi, H., Azhdari‐Zarmehri, H., Ghaemi-Jandabi, M., Abbasi-Mazar, A., Mohajer, Y., & Darana, S. P. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112650 · Cited by 32 · see citing works
Orexin-1 receptor signaling in ventral tegmental area mediates cue-driven demand for cocaine
Pantazis, C. B., James, M. H., O’Connor, S. L., Shin, N., & Aston‐Jones, G. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01173-5 · Cited by 31 · see citing works
Pruimboom, L., Raison, C. L., & Muskiet, F. A. J. (2015) · Behavioural Neurology · doi:10.1155/2015/569869 · Cited by 30 · see citing works
Protracted maturation of forebrain afferent connections of the ventral tegmental area in the rat
Yetnikoff, L., Reichard, R. A., Schwartz, Z. M., Parsely, K. P., & Zahm, D. S. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23459 · Cited by 30 · see citing works
Gene–Physical Activity Interactions in the Etiology of Obesity: Behavioral Considerations
Dishman, R. K. (2008) · Obesity · doi:10.1038/oby.2008.520 · Cited by 30 · see citing works
del Cid‐Pellitero, E., & Garzón, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.058 · Cited by 30 · see citing works
Slater, P. G., Noches, V., & Gysling, K. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13113 · Cited by 30 · see citing works
Wiskerke, J., James, M. H., & Aston‐Jones, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.04.017 · Cited by 29 · see citing works
López, J. M., Domínguez, L., Moreno, N., Morona, R., Joven, A., & González, A. (2009) · Brain Behavior and Evolution · doi:10.1159/000274978 · Cited by 29 · see citing works
Hypocretin mechanisms in nicotine addiction: evidence and speculation
Corrigall, W. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1588-2 · Cited by 29 · see citing works
Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area
Hrabovszky, E., Molnár, C. S., Borsay, B. Á., Gergely, P. A., Herczeg, L., & Liposits, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083029 · Cited by 29 · see citing works
López, J. M., Domínguez, L., Moreno, N., & González, A. (2009) · Peptides · doi:10.1016/j.peptides.2009.01.013 · Cited by 28 · see citing works
Lee, J., Raycraft, L. M., & Johnson, A. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113234 · Cited by 27 · see citing works
Palotai, M., Telegdy, G., & Jászberényi, M. (2014) · Peptides · doi:10.1016/j.peptides.2014.05.003 · Cited by 27 · see citing works
Role of lateral hypothalamus in two aspects of attention in associative learning
Wheeler, D. S., Wan, S., Miller, A., Angeli, N. F., Adileh, B., Hu, W., & Holland, P. C. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12592 · Cited by 27 · see citing works
Steiner, M. A., Sciarretta, C., Pasquali, A., & Jenck, F. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00165 · Cited by 27 · see citing works
Dergacheva, O., Yamanaka, A., Schwartz, A. R., Polotsky, V. Y., & Mendelowitz, D. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00572.2016 · Cited by 27 · see citing works
Lateral hypothalamus dopamine D1-like receptors and glucose-conditioned flavor preferences in rats
Touzani, K., Bodnar, R. J., & Sclafani, A. J. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.06.006 · Cited by 27 · see citing works
Hata, T., Chen, J., Ebihara, K., Date, Y., Ishida, Y., & Nakahara, D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07808.x · Cited by 25 · see citing works
Dehkordi, O., Rose, J. E., GarcAAa, M. I. D., Millis, R. M., Mirzaei, S. A., Manaye, K. F., & Jayam‐Trouth, A. (2017) · Journal of Alcoholism and Drug Dependence · doi:10.4172/2329-6488.1000273 · Cited by 24 · see citing works
Ascending orexinergic pathways and alcohol-seeking
Brown, R. M., & Lawrence, A. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.014 · Cited by 22 · see citing works
The action of orexin B on passive avoidance learning. Involvement of neurotransmitters
Palotai, M., Telegdy, G., Ekwerike, A., & Jászberényi, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.016 · Cited by 22 · see citing works
Sprow, G. M., Rinker, J. A., Lowery-Gointa, E. G., Sparrow, A. M., Navarro, M., & Thiele, T. E. (2015) · Addiction Biology · doi:10.1111/adb.12264 · Cited by 22 · see citing works
James, M. H., Yeoh, J. W., Graham, B. A., & Dayas, C. V. (2012) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s4-008 · Cited by 22 · see citing works
Kalló, I., Molnár, C. S., Szöke, S., Fekete, C., Hrabovszky, E., & Liposits, Z. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00112 · Cited by 21 · see citing works
Campbell, E. J., Barker, D. J., Nasser, H. M., Kaganovsky, K., Dayas, C. V., & Marchant, N. J. (2017) · Behavioral Neuroscience · doi:10.1037/bne0000185 · Cited by 21 · see citing works
Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation
Mohammadkhani, A., Mitchell, C. S., James, M. H., Borgland, S. L., & Dayas, C. V. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17325 · Cited by 20 · see citing works
- Authors
- Balcita‐Pedicino, J. J., & Sesack, S. R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Sesack, Susan R.
- ORCID
- Sesack, Susan R.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2007-06-08
- Volume
- 503
- Issue
- 5
- Pages
- 668-684
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2044786960
- Cited by
- 150
- References
- 101
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 14
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH067937, R01MH067937)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- orexin, ventral tegmental area, dopaminergic neurons, GABAergic neurons, varicose axons, tyrosine hydroxylase, lateral hypothalamus, midbrain projections, dense core vesicles
- MeSH terms
- Orexins, Animals, Axons, Dopamine, gamma-Aminobutyric Acid, Male, Neurons, Neuropeptides, Synapses, Ultrasonography, Microscopy, Immunoelectron, Silver Staining, Rats, Sprague-Dawley, Ventral Tegmental Area, Intracellular Signaling Peptides and Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
