The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
Open accessAbstract
We report that MOP3 is a general dimerization partner for a subset of the basic-helix–loop–helix (bHLH)-PER–ARNT–SIM (PAS) superfamily of transcriptional regulators. We demonstrated that MOP3 interacts with MOP4, CLOCK, hypoxia-inducible factor 1α (HIF1α), and HIF2α. A DNA selection protocol revealed that the MOP3-MOP4 heterodimer bound a CACGTGA-containing DNA element. Transient transfection experiments demonstrated that the MOP3-MOP4 and MOP3-CLOCK complexes bound this element in COS-1 cells and drove transcription from a linked luciferase reporter gene. We also deduced the high-affinity DNA binding sites for MOP3-HIF1α complex (TACGTGA) and used transient transfection experiments to demonstrate that the MOP3-HIF1α and MOP3-HIF2α heterodimers bound this element, drove transcription, and responded to cellular hypoxia. Finally, we found that MOP3 mRNA expression overlaps in a number of tissues with each of its four potential partner molecules in vivo .
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Hypoxia — a key regulatory factor in tumour growth
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Mop3 is an essential component of the master circadian pacemaker in mammals.
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Self-citationPAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
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Metadata
- Authors
- Hogenesch, J. B., Gu, Y.-Z., Jain, S., & Bradfield, C. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-05-12
- Volume
- 95
- Issue
- 10
- Pages
- 5474-5479
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088348233
- Cited by
- 787
- References
- 8
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. https://app.cochat.ai/papers/10.1073/pnas.95.10.5474
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- Hogenesch, J. B., Gu, Y.-Z., Jain, S., & Bradfield, C. A. (1998). The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.10.5474
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
