The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD
Open accessAbstract
Angiostatin, a fragment of plasminogen, has been identified and characterized as an endogenous inhibitor of neovascularization. We show that angiostatin treatment of endothelial cells in the absence of growth factors results in an increased apoptotic index whereas the proliferation index is unchanged. Angiostatin also inhibits migration and tube formation of endothelial cells. Angiostatin treatment has no effect on growth factor-induced signal transduction but leads to an RGD-independent induction of the kinase activity of focal adhesion kinase, suggesting that the biological effects of angiostatin relate to subversion of adhesion plaque formation in endothelial cells.
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Cites
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Endostatin Induces Endothelial Cell Apoptosis
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Metadata
- Authors
- Claesson-Welsh, L., Welsh, M., Ito, N., Anand-Apte, B., Soker, S., Zetter, B., O’Reilly, M., & Folkman, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-05-12
- Volume
- 95
- Issue
- 10
- Pages
- 5579-5583
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1963776052
- Cited by
- 349
- References
- 20
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. https://app.cochat.ai/papers/10.1073/pnas.95.10.5579
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- Claesson-Welsh, L., Welsh, M., Ito, N., Anand-Apte, B., Soker, S., Zetter, B., O’Reilly, M., & Folkman, J. (1998). Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.10.5579
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
