Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

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Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients

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Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

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Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder

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The helix-loop-helix gene E2A is required for B cell formation

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Increase in Free Choice Oral Ethanol Self‐Administration in Catechol‐O‐Methyltransferase Gene‐Disrupted Male Mice

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Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma

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Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry

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Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney

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Cortical signal-to-noise ratio: insight into the pathophysiology and genetics of schizophrenia

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Val/Met Polymorphism of the COMT Gene Moderates the Association Between Job Strain and Early Atherosclerosis in Young Men

Hintsanen, M., Elovainio, M. J., Puttonen, S., Mika Kivimaki, B., Lehtimäki, T. J., Kähönen, M. A. P., Juonala, M., Rontu, R., Viikari, J. S. A., Raitakari, O. T., et al. (2008) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e318165c7ec · Cited by 21

No Association of COMT (Val158Met) Genotype with Brain Structure Differences between Men and Women

Barnes, A., Isohanni, M. K., Barnett, J. H., Pietiläinen, O. P. H., Veijola, J. M., Miettunen, J., Paunio, T., Tanskanen, P., Ridler, K., Suckling, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033964 · Cited by 22

Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice

Solís, Ó., García-Montes, J.-R., García‐Sanz, P., Herranz, A. S., Asensio, M.-J., Kang, G., Hiroi, N., & Moratalla, R. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.03.006 · Cited by 21

Hispidulin attenuates the social withdrawal in isolated disrupted‐in‐schizophrenia‐1 mutant and chronic phencyclidine‐treated mice

Mouri, A., Lee, H., Mamiya, T., Aoyama, Y., Matsumoto, Y., Kubota, H., Huang, W., Chiou, L., & Nabeshima, T. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15043 · Cited by 21

Human dopamine receptor D2/D3 availability predicts amygdala reactivity to unpleasant stimuli

Kobiella, A., Vollstädt‐Klein, S., Fauth‐Bühler, M., Graf, C., Buchholz, H., Bernow, N., Yakushev, I. Y., Landvogt, C., Schreckenberger, M., Gründer, G., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20900 · Cited by 21

Striatal D 2 receptor binding in 22q11 deletion syndrome: an [ 123 I]IBZM SPECT study

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Sildenafil Therapy Normalizes the Aberrant Metabolomic Profile in the Comt−/− Mouse Model of Preeclampsia/Fetal Growth Restriction

Stanley, J. L., Sulek, K., Andersson, I. J., Davidge, S. T., Kenny, L. C., Sibley, C. P., Mandal, R., Wishart, D. S., Broadhurst, D., & Baker, P. N. (2015) · Scientific Reports · doi:10.1038/srep18241 · Cited by 21

Handbook of neurochemistry and molecular neurobiology, schizophrenia

Lajtha, Á., Javitt, D. C., & Kantrowitz, J. T. (2009) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) · doi:10.1007/978-0-387-30410-6 · Cited by 21

The biochemical womb of schizophrenia: A review

Gaur, N., Gautam, S., Gaur, M. C., Sharma, P., Dadheech, G., & Mishra, S. (2008) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-008-0071-x · Cited by 19

Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals

Melchitzky, D. S., Erickson, S. L., & Lewis, D. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.056 · Cited by 21

Mouse anxiety: the power of knockout

Lesch, K. (2001) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500016 · Cited by 20

The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users

Fagundo, A. B., Cuyàs, E., Verdejo‐García, A., Khymenets, O., Langohr, K., Martín‐Santos, R., Farré, M., & de la Torre, R. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109354926 · Cited by 22

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Barkus, C., Korn, C., Stumpenhorst, K., Laatikainen, L. M., Ballard, D., Lee, S., Sharp, T., Harrison, P. J., Bannerman, D. M., Weinberger, D. R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.119 · Cited by 20

Subsecond Regulation of Synaptically Released Dopamine by COMT in the Olfactory Bulb

Cockerham, R. E., Liu, S., Cachope, R., Kiyokage, E., Cheer, J. F., Shipley, M. T., & Puché, A. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0658-16.2016 · Cited by 20

Genetische Befunde bei der Aufmerksamkeitsdefizit- und Hyperaktivitätsstörung (ADHS)

SCHIMMELMANN, B. G., Friedel, S., Christiansen, H., Dempfle, A., Hinney, A., & Hebebrand, J. (2006) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917.34.6.425 · Cited by 20

Interacting Effect of Catechol-O-Methyltransferase (COMT) and Monoamine Oxidase A (MAOA) Gene Polymorphisms, and Stressful Life Events on Aggressive Behavior in Chinese Male Adolescents

Wang, M., Li, H., Deater-Deckard, K., & Zhang, W. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01079 · Cited by 19

Catechol-O-methyltransferase Val158Met genotype moderates the effect of disorganized attachment on social development in young children

Hygen, B. W., Guzey, I. C., Belsky, J., Berg-Nielsen, T. S., & Wichstrøm, L. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000492 · Cited by 19

Early Prevention of Severe Neurodevelopmental Behavior Disorders: An Integration

Schroeder, S. R., & Courtemanche, A. B. (2012) · Journal of Mental Health Research in Intellectual Disabilities · doi:10.1080/19315864.2011.593697 · Cited by 19

Augmenting Frontal Dopamine Tone Enhances Maintenance over Gating Processes in Working Memory

Furman, D. J., Zhang, Z., Chatham, C. H., Good, M., Badre, D., Hsu, M., & Kayser, A. S. (2020) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01641 · Cited by 25

Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease

Muellner, J., Gharrad, I., Habert, M., Kas, A., Martini, J., Cormier‐Dequaire, F., Tahiri, K., Vidailhet, M., Meier, N., Brice, A., et al. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.02.009 · Cited by 19

Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver

Fornes, R., Manti, M., Qi, X., Vorontsov, E. A., Sihlbom, C., Nystrom, J. C., Jerlhag, E., Maliqueo, M. A., Hirschberg, A. L., Carlström, M., et al. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0314-8 · Cited by 19

Tolcapone Treatment for Cognitive and Behavioral Symptoms in Behavioral Variant Frontotemporal Dementia: A Placebo-Controlled Crossover Study

Fremont, R., Manoochehri, M., Armstrong, N. M., Mattay, V. S., Apud, J. A., Tierney, M. C., Devanand, D. P., Gazes, Y., Habeck, C. G., Wassermann, E. M., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191265 · Cited by 19

Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice

Odlind, C., Reenilä, I., Männistö, P. T., Juvonen, R. O., Uhlén, S., Gogos, J. A., Karayiorgou, M., & Hansell, P. (2002) · BMC Physiology · doi:10.1186/1472-6793-2-14 · Cited by 19

COMT Val158met genotype and striatal D2/3 receptor binding in adults with 22q11 deletion syndrome

Boot, E., Booij, J., Zinkstok, J., Baas, F., Swillen, A., Owen, M. J., Murphy, D., Murphy, K. C., LINSZEN, D. H., & van Amelsvoort, T. (2011) · Synapse · doi:10.1002/syn.20932 · Cited by 19

Engineered modeling and the secrets of Parkinson's disease

Vila, M., Wu, D. C., & Przedborski, S. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01984-6 · Cited by 18

Perception of emotion in facial stimuli: The interaction of ADRA2A and COMT genotypes, and sex

Tamm, G., Kreegipuu, K., & Harro, J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.07.012 · Cited by 18

From neural to genetic substrates of panic disorder: Insights from human and mouse studies

Santos, M., D’Amico, D., & Dierssen, M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.039 · Cited by 19

Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in japanese healthy volunteers

Ishii, G., Suzuki, A., Oshino, S., Shiraishi, H., Matsumoto, Y., Otani, K., & Goto, K. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.05.005 · Cited by 20

Tolcapone,COMTPolymorphisms and Pharmacogenomic Treatment of Schizophrenia

Bitsios, P., & Roussos, P. (2011) · Pharmacogenomics · doi:10.2217/pgs.10.206 · Cited by 18

Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli

Bianco, L. L., Blasi, G., Taurisano, P., Giorgio, A. D., Ferrante, F. J., Ursini, G., Fazio, L., Gelao, B., Romano, R., Papazacharias, A., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291712001134 · Cited by 19

Right inferior frontal cortex activity correlates with tolcapone responsivity in problem and pathological gamblers

Kayser, A. S., Vega, T. A., Weinstein, D., Peters, J., & Mitchell, J. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.12.022 · Cited by 19

Catechol‐O‐methyltransferase Val158Met polymorphism associates with affect and cortisol levels in women

Hill-Bowen, L. D., Lorenzetti, M. S., Lyle, S. M., Fins, A. I., Tartar, A., & Tartar, J. L. (2018) · Brain and Behavior · doi:10.1002/brb3.883 · Cited by 17

The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review

Morris, K. A., Grace, S., Woods, W., Dean, B., & Rossell, S. L. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14748 · Cited by 18

Pharmacogenetics

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Contribution of nonprimate animal models in understanding the etiology of schizophrenia

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Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase.

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Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim, B. O., & Derksen, J. J. L. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.005 · Cited by 20

Pyridoxine 5′-phosphate oxidase is a candidate gene responsible for hypertension in Dahl-S rats

Okuda, T., Sumiya, T., Iwai, N., & Miyata, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.149 · Cited by 18

SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex

Hatayama, M., Katayama, K., Kawahara, Y., Matsunaga, H., Takashima, N., Iwayama, Y., Matsumoto, Y., Nishi, A., Yoshikawa, T., & Aruga, J. (2022) · Communications Biology · doi:10.1038/s42003-022-03891-y · Cited by 17

Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor α Axis

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Anxiety as a neurodevelopmental disorder in a neuronal subpopulation: Evidence from gene expression data

Viggiano, A., Cacciola, G., Widmer, D. A. J., & Viggiano, D. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.032 · Cited by 17

Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes

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Adolescent cannabinoid exposure interacts with other risk factors in schizophrenia: A review of the evidence from animal models

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Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study

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COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder

Tükel, R., Gurvit, H. I., Öztürk, N., Özata, B., Ertekin, B. A., Ertekin, E., Baran, B., Kalem, Ş. A., Büyükgök, D., & Direskeneli, G. S. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12040103 · Cited by 21

Comprehensive analysis of nine monoamines and metabolites in small amounts of peripheral murine (C57Bl/6 J) tissues

Nagler, J., Schriever, S. C., Angelis, M. D., Pfluger, P. T., & Schramm, K. (2017) · Biomedical Chromatography · doi:10.1002/bmc.4151 · Cited by 18

Acupuncture Resolves Persistent Pain and Neuroinflammation in a Mouse Model of Chronic Overlapping Pain Conditions

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Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods

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A B2 SINE insertion in the Comt1 gene (Comt1B2i) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains

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Schizophrenia: violence and comorbidity

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COMT Val/Met and Psychopathic Traits in Children and Adolescents: A Systematic Review and New Evidence of a Developmental Trajectory toward Psychopathy

Kant, T., Koyama, E., Zai, C. C., Beitchman, J. H., & Kennedy, J. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031782 · Cited by 16

Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disorders

Hatayama, M., & Aruga, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1080739 · Cited by 16

Using mouse models to investigate sex-linked genetic effects on brain, behaviour and vulnerability to neuropsychiatric disorders

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Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension

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Interaction Effects of BDNF and COMT Genes on Resting-State Brain Activity and Working Memory

Chen, W., Chen, C., Xia, M., Wu, K. L., Chen, C., He, Q., Xue, G., Wang, W., Yong He, A., & Dong, Q. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00540 · Cited by 18

Irritable assault and variation in the COMT gene

Flory, J. D., Xu, K., New, A. S., Finch, T., Goldman, D. A., & Siever, L. J. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3281c8f126 · Cited by 16

Perinatal asphyxia alters neuregulin-1 and COMT gene expression in the medial prefrontal cortex in rats

Wakuda, T., Iwata, K., Iwata, Y., Anitha, A., Takahashi, T., Yamada, K., Vasu, M. M., Matsuzaki, H., Suzuki, K., & Mori, N. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.08.002 · Cited by 16

No association between catechol-O-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children

Yatsuga, C., Toyohisa, D., Fujisawa, T. X., Nishitani, S., Shinohara, K., Matsuura, N., Ikeda, S., Muramatsu, M., Hamada, A., & Tomoda, A. (2013) · Brain and Development · doi:10.1016/j.braindev.2013.08.006 · Cited by 16

Influence ofCOMTgenotype and affective distractors on the processing of self-generated thought

Kilford, E. J., Dumontheil, I., Wood, N. W., & Blakemore, S. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu118 · Cited by 16

Genetics of panic disorder: focus on association studies and therapeutic perspectives

Jacob, C., Domschke, K., Gajewska, A., Warrings, B., & Deckert, J. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.76 · Cited by 16

How Brain Arousal Mechanisms Work

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Chromosome 22 Deletion Syndrome And Schizophrenia

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Genes and Neuroimaging: Advances in Psychiatric Research

Gallinat, J., Bauer, M., & Heinz, A. (2008) · Neurodegenerative Diseases · doi:10.1159/000135612 · Cited by 16

Catechol-O-methyltransferase gene regulation in rat frontal cortex

Fatemi, S. H., & Folsom, T. D. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001958 · Cited by 16

Dimensional Deconstruction and Reconstruction of CNV-Associated Neuropsychiatric Disorders

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Serotonin and Aggression

Quadros, I. M., Takahashi, A., & Miczek, K. A. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70106-5 · Cited by 18

Impact of COMT genotype on serotonin-1A receptor binding investigated with PET

Baldinger, P., Hahn, A., Mitterhauser, M., Kranz, G. S., Friedl, M., Wadsak, W., Kraus, C., Ungersboeck, J., Hartmann, A. M., Giegling, I., et al. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0621-8 · Cited by 15

Aggression in Psychoses

Volavka, J. (2014) · Advances in Psychiatry · doi:10.1155/2014/196281 · Cited by 15

Genetic Polymorphisms Regulating Dopamine Signaling in the Frontal Cortex Interact to Affect Target Detection under High Working Memory Load

Smith, C. T., Swift‐Scanlan, T., & Boettiger, C. A. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00501 · Cited by 15

A neurogenetics approach to defining differential susceptibility to institutional care

Brett, Z. H., Sheridan, M. A., Humphreys, K., Smyke, A. T., Gleason, M. M., Fox, N. A., Zeanah, C. H., Nelson, C. A., & Drury, S. S. (2014) · International Journal of Behavioral Development · doi:10.1177/0165025414538557 · Cited by 17

Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism

Weinsanto, I., Mouheiche, J., Laux‐Biehlmann, A., Aouad, M., Maduna, T., Petit-Demoulière, N., Chavant, V., Poisbeau, P., Darbon, P., Charlet, A., et al. (2018) · Molecular Pain · doi:10.1177/1744806917754142 · Cited by 15

Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice

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