The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
Open accessAbstract
Catechol- O -methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. By means of homologous recombination in embryonic stem cells, a strain of mice in which the gene encoding the COMT enzyme has been disrupted was produced. The basal concentrations of brain catecholamines were measured in the striatum, frontal cortex, and hypothalamus of adult male and female mutants. Locomotor activity, anxiety-like behaviors, sensorimotor gating, and aggressive behavior also were analyzed. Mutant mice demonstrated sexually dimorphic and region-specific changes of dopamine levels, notably in the frontal cortex. In addition, homozygous COMT-deficient female (but not male) mice displayed impairment in emotional reactivity in the dark/light exploratory model of anxiety. Furthermore, heterozygous COMT-deficient male mice exhibited increased aggressive behavior. Our results provide conclusive evidence for an important sex- and region-specific contribution of COMT in the maintenance of steady-state levels of catecholamines in the brain and suggest a role for COMT in some aspects of emotional and social behavior in mice.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The role of COMT in aggression was initially supported by observations of hostility in mice deficient in Comt and the negative correlation between COMT levels and hostility in men with behavioral problems as children [57, 58]; reviewed in Qayyum et al. (2015) [59].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [57]
In the citing paper
“When early life stress is not taken into account, however, the findings on the relationship between MAOA or COMT and aggression or alcohol use are mixed (Gogos et al. 1998; Bortolato et al. 2011; Ficks And Waldman 2014; Qayyum et al. 2015; Lovallo et al. 2019; Godar et al. 2019; Kaya et al. 2021).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Gogos et al. 1998
In the citing paper
“This is consistent with evidence that COMTVal158Met is differentially expressed across genders (Dempster et al, 2006; Gogos et al, 1998).”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Gogos et al, 1998
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
Crawley, J. N., & Goodwin, F. K. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90067-2 · Cited by 1,432
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225
Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients
Swerdlow, N. R. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020063007 · Cited by 708
Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.
Karayiorgou, M., Morris, M. A., Morrow, B., Shprintzen, R. J., Goldberg, R., Borrow, J., Gos, A., Nestadt, G., Wolyniec, P. S., & Lasseter, V. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7612 · Cited by 628
Self-citationHaloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder
McDougle, C. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950040046006 · Cited by 566
The helix-loop-helix gene E2A is required for B cell formation
ZHUANG, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90076-0 · Cited by 545
Research works printed but not linked: 2
- W Ladosky, H T Schneider Br J Med Biol Res 14, 409–413 (1981).
- M H Grossman, J B Littrell, R Weinstein, C Szumlanski, R M Weinshilboum Trans Neurosci Soc 18, 70, (Abstr.). (1992).
Cited by
Sorted by citations
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673
DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
Jerome, L. A., & Papaioannou, V. E. (2001) · Nature Genetics · doi:10.1038/85845 · Cited by 1,076
Männistö, P. T., & Kaakkola, S. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01423-6 · Cited by 1,068
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020
Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
Williams‐Gray, C. H., Evans, J., Goris, A., Foltynie, T., Ban, M., Robbins, T. W., Brayne, C., Kolachana, B. S., Weinberger, D. R., Sawcer, S. J., et al. (2009) · Brain · doi:10.1093/brain/awp245 · Cited by 1,017
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 978
Measuring normal and pathological anxiety-like behaviour in mice: a review
Belzung, C., & Griebel, G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00291-1 · Cited by 912
Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893
Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300542 · Cited by 769
The correlative triad among aging, dopamine, and cognition: Current status and future prospects
Bäckman, L., Nyberg, L. H., Lindenberger, U., Li, S., & Farde, L. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.005 · Cited by 795
Prefrontal neurons and the genetics of schizophrenia
Weinberger, D. R., Egan, M. F., Bertolino, A., Callicott, J. H., Mattay, V. S., Lipska, B. K., Berman, K. F., & Goldberg, T. E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01252-5 · Cited by 751
A Highly Significant Association between a COMT Haplotype and Schizophrenia
Shifman, S., Bronstein, M., Sternfeld, M., Pisanté, A., Lev-Lehman, E., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/344514 · Cited by 691
Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
Tunbridge, E. M., Harrison, P. J., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.024 · Cited by 699
Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning
Frank, M. J., Moustafa, A. A., Haughey, H. M., Curran, T., & Hutchison, K. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706111104 · Cited by 696
Schizophrenia: Diverse Approaches to a Complex Disease
Sawa, A., & Snyder, S. H. (2002) · Science · doi:10.1126/science.1070532 · Cited by 599
Genes for schizophrenia? Recent findings and their pathophysiological implications
Harrison, P. J., & Owen, M. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12379-3 · Cited by 597
Durstewitz, D., & Seamans, J. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.015 · Cited by 586
Executive Subprocesses in Working Memory
Goldberg, T. E., Egan, M. F., Gscheidle, T., Coppola, R., Weickert, T. W., Kolachana, B. S., Goldman, D. A., & Weinberger, D. R. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.889 · Cited by 586
Catecholaminergic systems in stress: structural and molecular genetic approaches
Kvetnansky, R., Sabban, E. L., & Palkovits, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2006 · Cited by 548
22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia
Karayiorgou, M., Simon, T. J., & Gogos, J. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2841 · Cited by 474
Self-citationFrank, M. J., Doll, B. B., Oas-Terpstra, J., & Moreno, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2342 · Cited by 479
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
Meyer-Lindenberg, A., Kohn, P. D., Kolachana, B., Kippenhan, S., McInerney-Leo, A., Nussbaum, R., Weinberger, D. R., & Berman, K. F. (2005) · Nature Neuroscience · doi:10.1038/nn1438 · Cited by 428
Sex differences in animal models of psychiatric disorders
Kokras, N., & Dalla, C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12710 · Cited by 441
Tunbridge, E. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1124-04.2004 · Cited by 423
Collins, A. G. E., & Frank, M. J. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07980.x · Cited by 457
Smolka, M. N., Schumann, G., Wrase, J., Grüsser, S. M., Flor, H., Mann, K. F., Braus, D. F., Goldman, D. A., Büchel, C., & Heinz, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1792-04.2005 · Cited by 422
50 years of hurdles and hope in anxiolytic drug discovery
Griebel, G., & Holmes, A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4075 · Cited by 430
Barnett, J. H., Scoriels, L., & Munafò, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.005 · Cited by 412
Cristofori, I., Cohen‐Zimerman, S., & Grafman, J. H. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804281-6.00011-2 · Cited by 526
Drabant, E. M., Hariri, A. R., Meyer‐Lindenberg, A., Muñoz, K. E., Mattay, V. S., Kolachana, B. S., Egan, M. F., & Weinberger, D. R. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1396 · Cited by 387
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
Kanasaki, K., Palmsten, K., Sugimoto, H., Ahmad, S., Hamano, Y., Xie, L., Parry, S., Augustin, H. G., Gattone, V. H., Folkman, J., et al. (2008) · Nature · doi:10.1038/nature06951 · Cited by 381
Paylor, R. E., Pourcain, B. S., Mupo, A., Ataliotis, P., Spencer, C. M., Sobotka, A., Sparks, C., Choi, C.-H., Oghalai, J. S., Curran, S. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600206103 · Cited by 381
Matsumoto, M., Weickert, C. S., Akil, M., Lipska, B. K., Hyde, T. M., Herman, M. M., Kleinman, J. E., & Weinberger, D. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00556-0 · Cited by 365
Genes and the parsing of cognitive processes
Goldberg, T. E., & Weinberger, D. R. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.05.011 · Cited by 356
Dopamine supersensitivity correlates with D2 High states, implying many paths to psychosis
Seeman, P. M., Weinshenker, D., Quirion, R., Srivastava, L. K., Bhardwaj, S. K., Grandy, D. K., Premont, R. T., Sotnikova, T. D., Boksa, P., El-Ghundi, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409766102 · Cited by 353
van den Buuse, M. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp132 · Cited by 352
Forming beliefs: Why valence matters
Sharot, T., & Garrett, N. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.11.002 · Cited by 345
Assessing the molecular genetics of attention networks
Fossella, J., Sommer, T., Fan, J., Wu, Y., Swanson, J. M., Pfaff, D. W., & Posner, M. I. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-14 · Cited by 339
Self-citationCatechol- O -Methyltransferase Genotype and Dopamine Regulation in the Human Brain
Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02008.2003 · Cited by 325
COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome
Gothelf, D., D, S. E. M., Thompson, T., Hinard, C., Penniman, L. C., Feinstein, C., Kwon, H., Jin, S., Jo, B., Antonarakis, S. E., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1572 · Cited by 318
From maps to mechanisms through neuroimaging of schizophrenia
Meyer‐Lindenberg, A. (2010) · Nature · doi:10.1038/nature09569 · Cited by 325
The age of anxiety: role of animal models of anxiolytic action in drug discovery
Cryan, J. F., & Sweeney, F. F. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01362.x · Cited by 327
Harrison, P. J., & Tunbridge, E. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301543 · Cited by 308
Escalated aggressive behavior: Dopamine, serotonin and GABA
de Almeida, R. M. M., Ferrari, P. F., Parmigiani, S., & Miczek, K. A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.004 · Cited by 303
The gene encoding proline dehydrogenase modulates sensorimotor gating in mice
Gogos, J. A., Sántha, M., Takacs, Z., Beck, K. D., Luine, V. N., Lucas, L., Nadler, J. V., & Karayiorgou, M. (1999) · Nature Genetics · doi:10.1038/7777 · Cited by 296
Self-citationEffect of Catechol- O -Methyltransferase val 158 met Genotype on Attentional Control
Blasi, G., Mattay, V. S., Bertolino, A., Elvevåg, B., Callicott, J. H., Das, S., Kolachana, B. S., Egan, M. F., Goldberg, T. E., & Weinberger, D. R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0476-05.2005 · Cited by 294
Mouse genetic models for prepulse inhibition: an early review
Geyer, M. A., McIlwain, K. L., & Paylor, R. E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001159 · Cited by 289
Bertolino, A., Caforio, G., Blasi, G., Candia, M. D., Latorre, V., Petruzzella, V., Altamura, M., Nappi, G., Papa, S., Callicott, J. H., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1798 · Cited by 283
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Wahlstrom, D., White, T., & Luciana, M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.007 · Cited by 277
“Conversely, COMT catalyzes catecholamines and appears to be most important in the PFC (Gogos et al., 1998), since COMT knockout mice exhibit increases in PFC DA despite unchanged striatal levels.”
BackgroundGatt, J. M., Burton, K., Williams, L. M., & Schofield, P. R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.09.014 · Cited by 281
Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia
Abi‐Dargham, A., & Moore, H. M. (2003) · The Neuroscientist · doi:10.1177/1073858403252674 · Cited by 279
The Genetic Basis of Addictive Disorders
Ducci, F., & Goldman, D. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.03.010 · Cited by 303
Barnett, J. H., Jones, P. B., Robbins, T. W., & Müller, U. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001973 · Cited by 274
Cognitive Effects of Nicotine: Recent Progress
Valentine, G. W., & Sofuoglu, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171103152136 · Cited by 302
Yavich, L., Forsberg, M., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0665-07.2007 · Cited by 269
Self-citationEnoch, M., Xu, K., Ferro, E., Harris, C. R., & Goldman, D. A. (2003) · Psychiatric Genetics · doi:10.1097/00041444-200303000-00006 · Cited by 267
Karayiorgou, M., Sobin, C. A., Blundell, M. L., Galke, B. L., Malinova, L., Goldberg, P. H., Ott, J., & Gogos, J. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00319-9 · Cited by 263
Self-citationChromosomal microdeletions: dissecting del22q11 syndrome
Lindsay, E. A. (2001) · Nature Reviews Genetics · doi:10.1038/35098574 · Cited by 261
Toward a molecular architecture of personality
Reif, A., & Lesch, K. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00267-x · Cited by 253
Papaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J., Weinberger, D. R., & Chen, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2077-08.2008 · Cited by 288
Monoamine Oxidase in Neuropsychiatry and Behavior
Shih, J. C., & Thompson, R. F. (1999) · The American Journal of Human Genetics · doi:10.1086/302562 · Cited by 250
Genetic approaches to addiction: genes and alcohol
Ducci, F., & Goldman, D. A. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02203.x · Cited by 253
Tolcapone improves cognition and cortical information processing in normal human subjects
Apud, J. A., Mattay, V., Chen, J., Kolachana, B. S., Callicott, J. H., Rasetti, R., Alce, G., Iudicello, J. E., Akbar, N., Egan, M. F., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301227 · Cited by 242
Functional and clinical neuroanatomy of morality
Fumagalli, M., & Priori, A. (2012) · Brain · doi:10.1093/brain/awr334 · Cited by 242
Krugel, L. K., Biele, G., Mohr, P. N. C., Li, S.-C., & Heekeren, H. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905191106 · Cited by 229
Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia
Gray, J. A., & Roth, B. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm074 · Cited by 227
Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
Meyer‐Lindenberg, A., Straub, R. E., Lipska, B. K., Verchinski, B. A., Goldberg, T. E., Callicott, J. H., Egan, M. F., Huffaker, S., Mattay, V. S., Kolachana, B. S., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30413 · Cited by 228
Prepulse inhibition and genetic mouse models of schizophrenia
Powell, S. B., Zhou, X., & Geyer, M. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.021 · Cited by 218
Craddock, N., Owen, M. J., & O'Donovan, M. C. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001808 · Cited by 216
Working Memory Contributions to Reinforcement Learning Impairments in Schizophrenia
Collins, A. G. E., Brown, J. K., Gold, J. M., Waltz, J. A., & Frank, M. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0989-14.2014 · Cited by 223
Genetics of human aggressive behaviour
Craig, I. W., & Halton, K. E. (2009) · Human Genetics · doi:10.1007/s00439-009-0695-9 · Cited by 213
Gadad, B. S., Jha, M. K., Czysz, A., Furman, J. L., Mayes, T. L., Emslie, M. P., & Trivedi, M. H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.001 · Cited by 205
The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities
Carpenter, W. T., & Koenig, J. I. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301639 · Cited by 218
Maternal programming of defensive responses through sustained effects on gene expression
Zhang, T.-Y., Bagot, R., Parent, C., Nesbitt, C., Bredy, T. W., Caldji, C., Fish, E., Anisman, H., Szyf, M., & Meaney, M. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.009 · Cited by 206
Thapar, A., Langley, K., Fowler, T., Rice, F. J., Turic, D., Whittinger, N., Aggleton, J. P., van den Bree, M. B. M., Owen, M. J., & O’Donovan, M. C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1275 · Cited by 201
Genetic animal models: focus on schizophrenia
Gainetdinov, R. R., Mohn, A. R., & Caron, M. G. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01886-5 · Cited by 201
Tunbridge, E., Weickert, C., Kleinman, J., Herman, M., Chen, J., Kolachana, B., Harrison, P., & Weinberger, D. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl032 · Cited by 197
Targeted gene mutation approaches to the study of anxiety-like behavior in mice
Holmes, A. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00012-4 · Cited by 200
COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET
Slifstein, M., Kolachana, B. S., Simpson, E. H., Tabares, P., Cheng, B., Duvall, M., Frankle, W. G., Weinberger, D. R., Laruelle, M. A., & Abi‐Dargham, A. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.19 · Cited by 195
Neurogenetics and Pharmacology of Learning, Motivation, and Cognition
Frank, M. J., & Fossella, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.96 · Cited by 195
Dopaminergic Genes Predict Individual Differences in Susceptibility to Confirmation Bias
Doll, B. B., Hutchison, K. E., & Frank, M. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6486-10.2011 · Cited by 184
Ursini, G., Bollati, V., Fazio, L., Porcelli, A., Iacovelli, L., Catalani, A., Sinibaldi, L., Gelao, B., Romano, R., Rampino, A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6631-10.2011 · Cited by 188
Rujescu, D., Giegling, I., Gietl, A. F., Hartmann, A. M., & Möller, H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01831-0 · Cited by 189
Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice
Käenmäki, M., Tammimäki, A., Myöhänen, T. T., Pakarinen, K., Amberg, C., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06889.x · Cited by 188
Self-citationGenetic determinants of aggression and impulsivity in humans
Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-011-0069-6 · Cited by 184
The pipeline and future of drug development in schizophrenia
Gray, J. A., & Roth, B. L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002062 · Cited by 182
Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap
Pratt, J. A., Winchester, C. L., Dawson, N., & MORRIS, B. J. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3649 · Cited by 199
The neurobiological basis of human aggression: A review on genetic and epigenetic mechanisms
Waltes, R., Chiocchetti, A. G., & Freitag, C. M. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32388 · Cited by 182
Volavka, J. (1999) · Journal of Neuropsychiatry · doi:10.1176/jnp.11.3.307 · Cited by 181
Paloyelis, Y., Asherson, P., Mehta, M. A., Faraone, S. V., & Kuntsi, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.124 · Cited by 180
Williams‐Gray, C. H., Hampshire, A., Robbins, T. W., Owen, A. M., & Barker, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0774-07.2007 · Cited by 181
Brain catecholamine metabolism in catechol‐O‐methyltransferase (COMT)‐deficient mice
Huotari, M., Gogos, J. A., Karayiorgou, M., Koponen, O., Forsberg, M., Raasmaja, A., Hyttinen, J. M. T., & Männistö, P. T. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01856.x · Cited by 180
Self-citationNeurobehavioral foundation of environmental reactivity.
Moore, S. R., & Depue, R. A. (2015) · Psychological Bulletin · doi:10.1037/bul0000028 · Cited by 183
Is COMT a Susceptibility Gene for Schizophrenia?
Williams, H. J., Owen, M. J., & O’Donovan, M. C. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm019 · Cited by 181
Metadata
- Authors
- Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M.
- Affiliations
- Hunter College (US)
- City University of New York (US)
- The Rockefeller University, New York, NY 10021; Columbia University, College of Physicians and Surgeons, Center for Neurobiology and Behavior, New York, NY 10032; and Hunter College, New York, NY 10021
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-08-18
- Volume
- 95
- Issue
- 17
- Pages
- 9991-9996
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21449
- OpenAlex
- W2105837661
- Cited by
- 864
- References
- 41
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 18 · 2019: 19 · 2018: 32 · 2017: 25 · 2016: 31 · 2015: 40 · 2014: 47 · 2013: 45 · 2012: 50
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- catechol-O-methyltransferase, catecholamine metabolism, dopamine, sexual dimorphism, anxiety-like behavior, aggression, sensorimotor gating, emotional reactivity, 22q11.2 deletion syndrome, striatum, frontal cortex, hypothalamus
- MeSH terms
- Amino Acid Sequence, Animals, Behavior, Animal, Mental Disorders, Brain, Catechol O-Methyltransferase, Catecholamines, Disease Models, Animal, Female, Heterozygote, Homozygote, Humans, Male, Mice, Inbred C57BL, Molecular Sequence Data, Phenotype, Sex Characteristics, Sequence Homology, Amino Acid, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
