The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
Open accessAbstract
Catechol- O -methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. By means of homologous recombination in embryonic stem cells, a strain of mice in which the gene encoding the COMT enzyme has been disrupted was produced. The basal concentrations of brain catecholamines were measured in the striatum, frontal cortex, and hypothalamus of adult male and female mutants. Locomotor activity, anxiety-like behaviors, sensorimotor gating, and aggressive behavior also were analyzed. Mutant mice demonstrated sexually dimorphic and region-specific changes of dopamine levels, notably in the frontal cortex. In addition, homozygous COMT-deficient female (but not male) mice displayed impairment in emotional reactivity in the dark/light exploratory model of anxiety. Furthermore, heterozygous COMT-deficient male mice exhibited increased aggressive behavior. Our results provide conclusive evidence for an important sex- and region-specific contribution of COMT in the maintenance of steady-state levels of catecholamines in the brain and suggest a role for COMT in some aspects of emotional and social behavior in mice.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The role of COMT in aggression was initially supported by observations of hostility in mice deficient in Comt and the negative correlation between COMT levels and hostility in men with behavioral problems as children [57, 58]; reviewed in Qayyum et al. (2015) [59].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [57]
In the citing paper
“When early life stress is not taken into account, however, the findings on the relationship between MAOA or COMT and aggression or alcohol use are mixed (Gogos et al. 1998; Bortolato et al. 2011; Ficks And Waldman 2014; Qayyum et al. 2015; Lovallo et al. 2019; Godar et al. 2019; Kaya et al. 2021).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Gogos et al. 1998
In the citing paper
“This is consistent with evidence that COMTVal158Met is differentially expressed across genders (Dempster et al, 2006; Gogos et al, 1998).”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Gogos et al, 1998
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
Crawley, J. N., & Goodwin, F. K. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90067-2 · Cited by 1,432
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225
Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients
Swerdlow, N. R. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020063007 · Cited by 708
Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.
Karayiorgou, M., Morris, M. A., Morrow, B., Shprintzen, R. J., Goldberg, R., Borrow, J., Gos, A., Nestadt, G., Wolyniec, P. S., & Lasseter, V. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7612 · Cited by 628
Self-citationHaloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder
McDougle, C. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950040046006 · Cited by 566
The helix-loop-helix gene E2A is required for B cell formation
ZHUANG, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90076-0 · Cited by 545
Flagged first, then by citations
Research works printed but not linked: 2
- W Ladosky, H T Schneider Br J Med Biol Res 14, 409–413 (1981).
- M H Grossman, J B Littrell, R Weinstein, C Szumlanski, R M Weinshilboum Trans Neurosci Soc 18, 70, (Abstr.). (1992).
Cited by
Sorted by citations
Items 201–300 of 863
Qayyum, A., C. Zai, C., Hirata, Y., K. Tiwari, A., Cheema, S., Nowrouzi, B., Beitchman, J., & Kennedy, L. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150612225836 · Cited by 95
Bertolino, A., Taurisano, P., Pisciotta, N., Blasi, G., Fazio, L., Romano, R., Gelao, B., Bianco, L. L., Lozupone, M., Giorgio, A. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009348 · Cited by 98
The Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective
Goto, Y., & Grace, A. A. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78002-3 · Cited by 96
Ovarian Cycle Effects on Immediate Reward Selection Bias in Humans: A Role for Estradiol
Smith, C. T., Sierra, Y., Oppler, S. H., & Boettiger, C. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0014-14.2014 · Cited by 93
Pain modality- and sex-specific effects of COMT genetic functional variants
Belfer, I., Segall, S. K., Lariviere, W. R., Smith, S. B., Dai, F., Slade, G. D., Rashid, N. U., Mogil, J. S., Campbell, C. M., Edwards, R. R., et al. (2013) · Pain · doi:10.1016/j.pain.2013.04.028 · Cited by 92
Lee, S. B., Wong, A. P., Kanasaki, K., Xu, Y., Shenoy, V. K., McElrath, T. F., Whitesides, G. M., & Kalluri, R. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090513 · Cited by 93
Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression
Meaney, M. J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306255.003.0007 · Cited by 92
Babovic, D., O’Tuathaigh, C. M. P., O'Connor, A. M., O'Sullivan, G. J., Tighe, O., Croke, D. T., Karayiorgou, M., Gogos, J. A., Cotter, D., & Waddington, J. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.006 · Cited by 90
Self-citationNorton, N., Kirov, G., Zammit, S., Jones, G., Jones, S., Owen, R., Krawczak, M., Williams, N. M., O’Donovan, M. C., & Owen, M. J. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10517 · Cited by 90
Prata, D. P., Mechelli, A., Fu, C. H. Y., Picchioni, M., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R. M., Collier, D. A., & McGuire, P. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903007106 · Cited by 89
Cheuk, D., & Wong, V. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9076-5 · Cited by 85
Tunbridge, E. M., Burnet, P. W. J., Sodhi, M., & Harrison, P. J. (2003) · Synapse · doi:10.1002/syn.10286 · Cited by 89
Kempton, M. J., Haldane, M., Jogia, J., Christodoulou, T., Powell, J. F., Collier, D. A., Williams, S., & Frangou, S. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009395 · Cited by 93
Marco‐Pallarés, J., Cucurell, D., Toni Cunillera, B., Krämer, U. M., Càmara, E., Nager, W., Bauer, P., Schüle, R., Schöls, L. J., Münte, T. F., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.006 · Cited by 92
Handbook of Reward and Decision Making
Dreher, J., & Tremblay, L. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374620-7.x0001-5 · Cited by 88
Animal models of gene–environment interactions in schizophrenia
Ayhan, Y., Sawa, A., Ross, C. A., & Pletnikov, M. V. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.010 · Cited by 87
L INKAGE A NALYSIS IN P SYCHIATRIC D ISORDERS : The Emerging Picture
Sklar, P. B. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.022502.103141 · Cited by 86
Bertolino, A., Giorgio, A. D., Blasi, G., Sambataro, F., Caforio, G., Sinibaldi, L., Latorre, V., Rampino, A., Taurisano, P., Fazio, L., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.001 · Cited by 85
Catechol-O-methyltransferase, dopamine, and sleep-wake regulation
Dauvilliers, Y. A., Tafti, M., & Landolt, H. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.10.006 · Cited by 93
Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice
Suzuki, G., Harper, K. M., Hiramoto, T., Sawamura, T., Lee, M., Kang, G., Tanigaki, K., Buell, M. R., Geyer, M. A., Trimble, W. S., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp086 · Cited by 86
Mouse models for psychiatric disorders
Seong, E., Seasholtz, A. F., & Burmeister, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02807-x · Cited by 86
Motahari, Z., Moody, S. A., Maynard, T. M., & LaMantia, A. (2019) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-019-9267-z · Cited by 92
Paterson, N. E., Ricciardi, J., Wetzler, C., & Hanania, T. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.10.001 · Cited by 86
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
Samsom, J., & Wong, A. H. C. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00013 · Cited by 88
Treatment of Cognitive Deficits Associated with Schizophrenia
Apud, J. A., & Weinberger, D. R. (2007) · CNS Drugs · doi:10.2165/00023210-200721070-00002 · Cited by 83
Ahmed, Z. M., Masmoudi, S., Kalay, E., Belyantseva, I. A., Mosrati, M. A., Collin, R. W. J., Riazuddin, S., Hmani‐Aifa, M., Venselaar, H., Kawar, M. N., et al. (2008) · Nature Genetics · doi:10.1038/ng.245 · Cited by 83
Dopamine-Based Reward Circuitry Responsivity, Genetics, and Overeating
Stice, E. M., Yokum, S., Zald, D. H., & Dagher, A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_89 · Cited by 81
Effects of sex and COMT genotype on environmentally modulated cognitive control in mice
Papaleo, F., Erickson, L., Liu, G., Chen, J., & Weinberger, D. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214397109 · Cited by 81
Animal models of gene–environment interaction in schizophrenia: A dimensional perspective
Ayhan, Y., McFarland, R., & Pletnikov, M. V. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.002 · Cited by 82
Polymorphisms in genes involved in neurotransmission in relation to smoking
Arinami, T., Ishiguro, H., & Onaivi, E. S. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00816-5 · Cited by 81
Helmstaedter, C., Mihov, Y., Toliat, M. R., Thiele, H., Nüernberg, P., Schoch, S., Surges, R., Elger, C. E., Kunz, W. S., & Hurlemann, R. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03603.x · Cited by 81
Huotari, M., Sántha, M., Lucas, L., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.043042 · Cited by 81
Self-citationLiou, Y., Tsai, S., Hong, C., Wang, Y.-C., & Lai, I. (2001) · Neuropsychobiology · doi:10.1159/000054858 · Cited by 80
Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype
Loughead, J., Wileyto, E. P., Valdez, J. N., Sanborn, P. M., Tang, K., Strasser, A. A., Ruparel, K., Ray, R., Gur, R. C., & Lerman, C. E. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.132 · Cited by 80
Patchev, V. K., & Patchev, A. V. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/vpatchev · Cited by 80
Long, J. M., LaPorte, P., Merscher, S., Funke, B., Saint-Jore, B., Puech, A., Kucherlapati, R., Morrow, B. E., Skoultchi, A. I., & Wynshaw-Boris, A. J. (2006) · Neurogenetics · doi:10.1007/s10048-006-0054-0 · Cited by 79
Frank, M. J., D’Lauro, C. J., & Curran, T. (2007) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.7.4.297 · Cited by 78
Kates, W. R., Antshel, K. M., AbdulSabur, N. Y., Colgan, D., Funke, B., Fremont, W. P., Higgins, A. M., Kucherlapati, R., & Shprintzen, R. J. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30284 · Cited by 79
Fernandes, C., Paya-Cano, J., Sluyter, F., D'Souza, U., Plomin, R., & Schalkwyk, L. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03358.x · Cited by 94
Mouse Models of 22q11 Deletion Syndrome
Paylor, R. E., & Lindsay, E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.018 · Cited by 77
Genetic Factors Modulating Outcome After Neurotrauma
McAllister, T. W. (2010) · PM&R · doi:10.1016/j.pmrj.2010.10.005 · Cited by 81
Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J. C., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. J., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0102-9 · Cited by 77
Molecular genetics and antisocial behavior: Where do we stand?
Iofrida, C., Palumbo, S., & Pellegrini, S. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214529508 · Cited by 81
Chen, J., Song, J., Yuan, P., Tian, Q., Ji, Y., Ren‐Patterson, R. F., Liu, G., Sei, Y., & Weinberger, D. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.262790 · Cited by 84
Dopamine Modulates Egalitarian Behavior in Humans
Sáez, I., Zhu, L., Set, E., Kayser, A. S., & Hsu, M. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.071 · Cited by 78
Azzam, A., & Mathews, C. A. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20013 · Cited by 76
Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior
Reynolds, L. M., Yetnikoff, L., Pokinko, M., Wodzinski, M., Epelbaum, J. G., Lambert, L. C., Cossette, M.-P., Arvanitogiannis, A., & Flores, C. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy247 · Cited by 75
Molecular genetic aspects of attention-deficit/hyperactivity disorder
Heiser, P., Friedel, S., Dempfle, A., Konrad, K., SMIDT, J., Grabarkiewicz, J., Herpertz‐Dahlmann, B., Remschmidt, H., & Hebebrand, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.010 · Cited by 76
Åberg, E., Losada, A. F., Sjöholm, L. K., Forsell, Y., & Lavebratt, C. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.08.009 · Cited by 75
Wang, T., Franke, P. E., Neidt, H., Cichon, S., Knapp, M., Lichtermann, D., Maier, W., Propping, P., & Nöthen, M. M. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000803 · Cited by 74
Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia
Sanders, A. R., Rusu, I., Duan, J., Molen, J. E. V., Hou, C., Schwab, S. G., Wildenauer, D. B., Martinez, M. M., & Gejman, P. V. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001586 · Cited by 74
Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans
Papaleo, F., Burdick, M., Callicott, J. H., & Weinberger, D. R. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.133 · Cited by 73
Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT
Marenco, S., Farmer, A. S., van der Veen, J. W. C., Geramita, M. A., Stern, A., Barnett, A. S., Kolachana, B. S., Radulescu, E., Zhang, F., Callicott, J. H., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.35 · Cited by 71
Didriksen, M., Fejgin, K., Nilsson, S. R. O., Birknow, M. R., Grayton, H. M., Larsen, P. H., Lauridsen, J. B., Nielsen, V., Celada, P., Santana, N., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150381 · Cited by 75
Tsai, S., Gau, Y. A., Hong, C., Liou, Y., Yu, Y. W. ‐., & Chen, T. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.017 · Cited by 72
Using conditional mutagenesis to study the brain
Morozov, A., Kellendonk, C., Simpson, E. H., & Tronche, F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00467-0 · Cited by 73
Genetically engineered mouse models of Parkinson's disease
Crabtree, D., & Zhang, J. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.07.019 · Cited by 73
Enoch, M., Waheed, J. F., Harris, C. R., Albaugh, B., & Goldman, D. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00045.x · Cited by 70
A Meta-Analysis of the Val158Met COMT Polymorphism and Violent Behavior in Schizophrenia
Singh, J. P., Volavka, J., Czobor, P., & Dorn, R. A. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043423 · Cited by 70
Roussos, P., Giakoumaki, S. G., & Bitsios, P. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.008 · Cited by 70
Shprintzen, R. J. (2005) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2005.04.009 · Cited by 70
The COMT val158met polymorphism and brain morphometry in healthy young adults
Zinkstok, J., Schmitz, N., van Amelsvoort, T., de Win, M. M. L., van den Brink, W., Baas, F., & LINSZEN, D. H. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.034 · Cited by 70
Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia
O’Tuathaigh, C. M. P., Kirby, B. P., Moran, P. M., & Waddington, J. L. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp125 · Cited by 73
Behan, Á. T., Hryniewiecka, M., O’Tuathaigh, C. M. P., Kinsella, A., Cannon, M. D., Karayiorgou, M., Gogos, J. A., Waddington, J. L., & Cotter, D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.24 · Cited by 67
Self-citationGothelf, D., Frisch, A., Michaelovsky, E., Weizman, A., & Shprintzen, R. J. (2009) · Journal of Mental Health Research in Intellectual Disabilities · doi:10.1080/19315860902756136 · Cited by 69
Prefrontal Electrophysiologic “Noise” and Catechol-O-Methyltransferase Genotype in Schizophrenia
Winterer, G., Egan, M. F., Kolachana, B. S., Goldberg, T. E., Coppola, R., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.023 · Cited by 69
Catechol-O-Methyltransferase and Pain
Kambur, O., & Männistö, P. T. (2010) · International review of neurobiology · doi:10.1016/b978-0-12-381326-8.00010-7 · Cited by 70
Dopamine, Locus of Control, and the Exploration-Exploitation Tradeoff
Kayser, A. S., Mitchell, J., Weinstein, D., & Frank, M. J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.193 · Cited by 73
A catechol- O -methyltransferase that is essential for auditory function in mice and humans
Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K. K., Tarantino, L. M., Roberts, A. J., Richardson, H. N., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807219105 · Cited by 68
Puech, A., Saint-Jore, B., Merscher, S., Russell, R. G., Chérif, D., Sirotkin, H. I., Xu, H., Factor, S. M., Kucherlapati, R., & Skoultchi, A. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.10090 · Cited by 68
Role of COMT in ADHD: a Systematic Meta-Analysis
Sun, H., Yuan, F.-F., Shen, X., Xiong, G., & Wu, J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8516-5 · Cited by 70
Vinkers, C. H., van Gastel, W. A., Schubart, C. D., van Eijk, K. R., Luykx, J. J., van Winkel, R., Joëls, M., Ophoff, R. A., Boks, M. P., Bruggeman, R., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.020 · Cited by 72
Wahlstrom, D., White, T., Hooper, C. J., Vrshek-Schallhorn, S., Oetting, W. S., Brott, M. J., & Luciana, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.045 · Cited by 66
The Catechol-O-Methyltransferase Gene
Tunbridge, E. M. (2010) · International review of neurobiology · doi:10.1016/b978-0-12-381326-8.00002-8 · Cited by 72
Prata, D. P., Mechelli, A., Fu, C. H. Y., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Howes, O. D., Kravariti, E., Demjaha, A., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.027 · Cited by 66
Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system
Flores, C. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100171 · Cited by 72
COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population
Armero, P., Muriel, C., Santos, J., Sánchez-Montero, F. J., Rodróguez, R. E., & González‐Sarmiento, R. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2004.06.005 · Cited by 66
COMT genotype affects prefrontal white matter pathways in children and adolescents
Thomason, M. E., Dougherty, R. F., Colich, N. L., Perry, L. M., Rykhlevskaia, E. I., Louro, H. M. C., Hallmayer, J. F., Waugh, C. E., Bammer, R., Glover, G. H., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.033 · Cited by 67
Study of the Catechol‐O‐Methyltransferase (COMT) Gene with High Aggression in Children
Hirata, Y., Zai, C. C., Nowrouzi, B., Beitchman, J. H., & Kennedy, J. L. (2013) · Aggressive Behavior · doi:10.1002/ab.21448 · Cited by 65
Holmboe, K., Nemoda, Z., Fearon, P. R. M., Csibra, G., Sasvári‐Székely, M., & Johnson, M. H. (2010) · Developmental Psychology · doi:10.1037/a0018180 · Cited by 69
Benjamin, J., Osher, Y., Lichtenberg, P., Bachner‐Melman, R., Gritsenko, I., Kotler, M., Belmaker, R. H., Valsky, V., Drendel, M., & Ebstein, R. P. (2000) · Neuropsychobiology · doi:10.1159/000026632 · Cited by 65
Bitanihirwe, B. K. Y., Weber, L., Feldon, J., & Meyer, U. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000192 · Cited by 69
Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children
Barnett, J. H., Heron, J., Goldman, D. A., Jones, P. B., & Xu, K. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08081251 · Cited by 63
Long, L. E., Chesworth, R., Arnold, J. C., & Karl, T. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1896-6 · Cited by 67
Brain white matter structure and COMT gene are linked to second-language learning in adults
Mamiya, P. C., Richards, T. L., Coe, B. P., Eichler, E. E., & Kuhl, P. K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606602113 · Cited by 66
Catechol-O-Methyltransferase Polymorphisms Predict Opioid Consumption in Postoperative Pain
Candiotti, K. A., Yang, Z., Buric, D., Arheart, K. L., Zhang, Y., Rodriguez, Y. F., Gitlin, M. C., Carvalho, E. M., Jaraba, I., & Wang, L. (2014) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000411 · Cited by 62
Sex differences in animal models of schizophrenia shed light on the underlying pathophysiology
Hill, R. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.014 · Cited by 61
Han, D. H., Park, D. B., Na, C., Kee, B. S., & Lee, Y. S. (2004) · Psychiatry Research · doi:10.1016/j.psychres.2004.06.013 · Cited by 62
Tunbridge, E. M., & Harrison, P. J. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_97 · Cited by 61
Pathways from Cannabis to Psychosis: A Review of the Evidence
Burns, J. K. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00128 · Cited by 61
Johnson, P. L., Federici, L. M., & Shekhar, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.027 · Cited by 64
O’Tuathaigh, C. M. P., Clarke, G. A., Walsh, J., Desbonnet, L., Petit, E., O’Leary, C., Tighe, O., Clarke, N. E., Karayiorgou, M., Gogos, J. A., et al. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001581 · Cited by 61
Self-citationCOMT Val158Met Genotype as a Risk Factor for Problem Behaviors in Youth
Albaugh, M. D., Harder, V. S., Althoff, R. R., Rettew, D. C., Ehli, E. A., Lengyel-Nelson, T., Davies, G. E., Ayer, L., Sulman, J., Stanger, C., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.015 · Cited by 60
Lapish, C. C., Ahn, S., Evangelista, L., So, K., Seamans, J. K., & Phillips, A. G. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1342-1 · Cited by 60
The influence of sex-linked genetic mechanisms on attention and impulsivity
Trent, S., & Davies, W. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.09.011 · Cited by 62
Sannino, S., Gozzi, A., Cerasa, A., Piras, F., Scheggia, D., Managò, F., Damiano, M., Galbusera, A., Erickson, L. C., Tonelli, D. D. P., et al. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu053 · Cited by 60
Lelli-Chiesa, G., Kempton, M. J., Jogia, J., Tatarelli, R., Girardi, P., Powell, J. F., Collier, D. A., & Frangou, S. (2010) · Psychological Medicine · doi:10.1017/s0033291710001431 · Cited by 59
Taerk, E., Grizenko, N., Amor, L. B., Lageix, P., Mbékou, V., Deguzman, R., Torkamanzehi, A., Ter-Stepanian, M., Baron, C., & Joober, R. (2004) · BMC Medical Genetics · doi:10.1186/1471-2350-5-30 · Cited by 60
Laatikainen, L. M., Sharp, T., Harrison, P. J., & Tunbridge, E. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061839 · Cited by 59
Metadata
- Authors
- Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M.
- Affiliations
- Hunter College (US)
- City University of New York (US)
- The Rockefeller University, New York, NY 10021; Columbia University, College of Physicians and Surgeons, Center for Neurobiology and Behavior, New York, NY 10032; and Hunter College, New York, NY 10021
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-08-18
- Volume
- 95
- Issue
- 17
- Pages
- 9991-9996
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21449
- OpenAlex
- W2105837661
- Cited by
- 864
- References
- 41
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 18 · 2019: 19 · 2018: 32 · 2017: 25 · 2016: 31 · 2015: 40 · 2014: 47 · 2013: 45 · 2012: 50
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- catechol-O-methyltransferase, catecholamine metabolism, dopamine, sexual dimorphism, anxiety-like behavior, aggression, sensorimotor gating, emotional reactivity, 22q11.2 deletion syndrome, striatum, frontal cortex, hypothalamus
- MeSH terms
- Amino Acid Sequence, Animals, Behavior, Animal, Mental Disorders, Brain, Catechol O-Methyltransferase, Catecholamines, Disease Models, Animal, Female, Heterozygote, Homozygote, Humans, Male, Mice, Inbred C57BL, Molecular Sequence Data, Phenotype, Sex Characteristics, Sequence Homology, Amino Acid, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
