The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785 · see citing works

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 4,557 · see citing works

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104 · see citing works

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., et al. (1997) · Nature Genetics · doi:10.1038/ng0497-356 · Cited by 2,742 · see citing works

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

del Peso, L., González‐García, M., Page, C., Herrera, R., & Núñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 2,213 · see citing works

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacoke, M., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-64 · Cited by 2,083 · see citing works

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Franke, T. F., Yang, S., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., & Tsichlis, P. N. (1995) · Cell · doi:10.1016/0092-8674(95)90534-0 · Cited by 2,006 · see citing works

LNCaP model of human prostatic carcinoma.

Horoszewicz, J. S., Leong, S. S., Kawinski, E., Karr, J. P., Rosenthal, H. E., Chu, T. M., MIRAND, E. A., & Murphy, G. P. (1983) · PubMed · Cited by 1,768 · see citing works

Pten is essential for embryonic development and tumour suppression

Cristofano, A. D., Pesce, B., Cordon‐Cardo, C., & Pandolfi, P. P. (1998) · Nature Genetics · doi:10.1038/1235 · Cited by 1,518 · see citing works

Mechanisms and consequences of activation of protein kinase B/Akt

Downward, J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80149-x · Cited by 1,304 · see citing works

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

Tamura, M., Gu, J., Matsumoto, K., Aota, S.-I., Parsons, R., & Yamada, K. M. (1998) · Science · doi:10.1126/science.280.5369.1614 · Cited by 1,215 · see citing works

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.Preprint

Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordán, J., Bellacosa, A., Tsichlis, P. N., & Hay, N. (1997) · Genes & Development · doi:10.1101/gad.11.6.701 · Cited by 1,074 · see citing works

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

Rodriguez‐Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A. J., & Downward, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80226-3 · Cited by 1,063 · see citing works

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

Bellacosa, A., Testa, J. R., Staal, S. P., & Tsichlis, P. N. (1991) · Science · doi:10.1126/science.1833819 · Cited by 939 · see citing works

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

Klingmüller, U., Lorenz, U. M., Cantley, L. C., Neel, B. G., & Lodish, H. F. (1995) · Cell · doi:10.1016/0092-8674(95)90351-8 · Cited by 927 · see citing works

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayPreprint

Gingras, A., Kennedy, S. G., O'Leary, M., Sonenberg, N., & Hay, N. (1998) · Genes & Development · doi:10.1101/gad.12.4.502 · Cited by 885 · see citing works

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

Li, D. M., & Sun, H. (1997) · PubMed · Cited by 872 · see citing works

Phosphorylation and Activation of p70 ^s6k by PDK1

Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science · doi:10.1126/science.279.5351.707 · Cited by 826 · see citing works

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. E., & Tonks, N. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9052 · Cited by 775 · see citing works

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

Staal, S. P. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.5034 · Cited by 772 · see citing works

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Alessi, D. R., Deák, M., Casamayor, A., Caudwell, F. B., MORRICE, N. A., Norman, D. G., Gaffney, P. R. J., Reese, C. B., MacDougall, C. N., Harbison, D., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00336-8 · Cited by 737 · see citing works

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factorPreprint

Paradis, S., & Ruvkun, G. (1998) · Genes & Development · doi:10.1101/gad.12.16.2488 · Cited by 711 · see citing works

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

Marte, B. M. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01097-9 · Cited by 696 · see citing works

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

Marsh, D. J., Dahia, P. L. M., Zheng, Z., Liaw, D., Parsons, R. E., Gorlin, R. J., & Eng, C. (1997) · Nature Genetics · doi:10.1038/ng0897-333 · Cited by 654 · see citing works

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

Whang, Y. E., Wu, X., Suzuki, H., Reiter, R. E., Tran, C., Vessella, R. L., SAID, J. W., Isaacs, W. B., & Sawyers, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5246 · Cited by 639 · see citing works

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Alessi, D. R., Kozlowski, M. T., Weng, Q.-P., MORRICE, N. A., & Avruch, J. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70037-5 · Cited by 574 · see citing works

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway

Skorski, T., Bellacosa, A., Nieborowska‐Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6151 · Cited by 567 · see citing works

Akt activation by growth factors is a multiple-step process: the role of the PH domain

Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S. E., Stokoe, D., McCormick, F. P., Feng, J., & Tsichlis, P. N. (1998) · Oncogene · doi:10.1038/sj.onc.1201947 · Cited by 548 · see citing works

From Form to Function: Signaling by Protein Tyrosine Phosphatases

Tonks, N. K., & Neel, B. G. (1996) · Cell · doi:10.1016/s0092-8674(00)81357-4 · Cited by 537 · see citing works

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

Ahmed, N. N., Grimes, H. L., Bellacosa, A., Chan, T. O., & Tsichlis, P. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3627 · Cited by 519 · see citing works

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

Mazure, N. M., Chen, E. Y., Laderoute, K. R., & Giaccia, A. J. (1997) · Blood · doi:10.1182/blood.v90.9.3322 · Cited by 498 · see citing works

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

Teng, D., Hu, R. H., Lin, H., Davis, T., Iliev, D., Frye, C., Swedlund, B., Hansen, K. L., Vinson, V. L., Gumpper, K. L., et al. (1997) · PubMed · Cited by 465 · see citing works

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

Furnari, F. B., Lin, H., Huang, H., & Cavenee, W. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12479 · Cited by 437 · see citing works

Translational control

(1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240470805 · Cited by 433 · see citing works

Switching Signals On or Off by Receptor Dimerization

Weiss, A., & Schlessinger, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81469-5 · Cited by 431 · see citing works

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

Chang, H. W., Aoki, M., Fruman, D. A., Auger, K. R., Bellacosa, A., Tsichlis, P. N., Cantley, L. C., Roberts, T. M., & Vogt, P. K. (1997) · Science · doi:10.1126/science.276.5320.1848 · Cited by 412 · see citing works

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

Rousseau, D. L., Kaspar, R. L., Rosenwald, I. B., Gehrke, L., & Sonenberg, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1065 · Cited by 401 · see citing works

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

Raitano, A., Halpern, J., Hambuch, T. M., & Sawyers, C. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11746 · Cited by 394 · see citing works

Recognition and specificity in protein tyrosine kinase-mediated signalling

Songyang, Z., & Cantley, L. C. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89103-3 · Cited by 370 · see citing works

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

Bellacosa, A., Testa, Staal, S., et al. (1991) · Science · doi:10.1126/science.254.5029.274 · Cited by 365 · see citing works

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

Matthews, R. J., Bowne, D. B., Flores, E. R., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.2396 · Cited by 364 · see citing works

Interleukin 3-dependent survival by the Akt protein kinase

Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D. R., & Franke, T. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11345 · Cited by 360 · see citing works

The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

Sun, H., & Tonks, N. K. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90134-1 · Cited by 345 · see citing works

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

Datta, K., Bellacosa, A., Chan, T. O., & Tsichlis, P. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30835 · Cited by 279 · see citing works

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3‐kinase

Jiménez, C., Jones, D. R., Rodriguez‐Viciana, P., González-Garcı́a, A., Leonardo, E., Wennström, S., von Kobbe, C., Toran, J. L., R‐Borlado, L., Calvo, V., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.3.743 · Cited by 269 · see citing works

Lipid-Regulated Kinases: Some Common Themes at Last

Downward, J. (1998) · Science · doi:10.1126/science.279.5351.673 · Cited by 198 · see citing works

AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation

Datta, K., Franke, T. F., Chan, T. O., Makris, A. M., Yang, S.-I., Kaplan, D. R., Morrison, D. K., Golemis, E. A., & Tsichlis, P. N. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2304 · Cited by 164 · see citing works

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

Cichy, S. B., Shahab Uddin, M. S., Danilkovich, A. V., Guo, S., Klippel, A., & Unterman, T. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6482 · Cited by 162 · see citing works

Translation control: Connecting mitogens and the ribosome

Peterson, R. T., & Schreiber, S. L. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70152-6 · Cited by 156 · see citing works

Prostate Tissue Specificity of the Prostate-Specific Antigen Promoter Isolated from a Patient with Prostate Cancer

Pang, S., Taneja, S. S., Dardashti, K., et al. (1995) · Human Gene Therapy · doi:10.1089/hum.1995.6.11-1417 · Cited by 113 · see citing works

Characterization of Hematopoietic Intracellular Protein Tyrosine Phosphatases: Description of a Phosphatase Containing an SH2 Domain and Another Enriched in Proline-, Glutamic Acid-, Serine-, and Threonine-Rich Sequences

Matthews, R. J., Bowne, D. B., Flores, E., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.2396-2405.1992 · Cited by 91 · see citing works

A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.

Muller, A. J., Pendergast, A. M., Havlik, M. H., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5087 · Cited by 78 · see citing works

Structural Requirements for Function of the Crkl Adapter Protein in Fibroblasts and Hematopoietic Cells

Senechal, K., Heaney, C., Druker, B. J., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5082 · Cited by 75 · see citing works

Protein Tyrosine Phosphatases and the Control of Cellular Signaling Responses

Tonks, N. K. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60578-5 · Cited by 68 · see citing works

The study of phosphoinositide 3-kinase function.

Vanhaesebroeck, B., Stein, R. C., & Waterfield, M. D. (1996) · PubMed · Cited by 58 · see citing works

A Limited Set of SH2 Domains Binds BCR through a High- Affinity Phosphotyrosine-Independent Interaction

Muller, A. J., Pendergast, A. M., Havlik, M. H., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5087-5093.1992 · Cited by 28 · see citing works

The development of androgen-independent prostate cancer.

Feldman, B. J., & Feldman, D. (2001) · Nature reviews. Cancer · doi:10.1038/35094009 · Cited by 2,326 · see citing works

Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts

Zhuang, L., Kim, J., Adam, R. M., Solomon, K. R., & Freeman, M. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200519935 · Cited by 567 · see citing works

PTEN: The down side of PI 3-kinase signalling

Leslie, N. R., & Downes, C. P. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00234-0 · Cited by 415 · see citing works

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in <i>PIK3CA</i> -Mutant Breast Cancer

Elkabets, M., Vora, S., Juric, D., Morse, N., Mino-Kenudson, M., Muranen, T., Tao, J., Campos, A. B., Rodon, J., Ibrahim, Y. H., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005747 · Cited by 332 · see citing works

Molecular cell biology of androgen receptor signalling

Bennett, N. C., Gardiner, R. A., Hooper, J. D., Johnson, D. W., & Gobe, G. C. (2010) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2009.11.013 · Cited by 292 · see citing works

PTENless means more

Stiles, B., Groszer, M., Wang, S., Jiao, J., & Wu, H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.06.008 · Cited by 230 · see citing works

Roles and regulation of Wnt signaling and β-catenin in prostate cancer

Verras, M., & Sun, Z. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.06.004 · Cited by 180 · see citing works

Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer

Feigin, M. E., Akshinthala, S. D., Araki, K., Rosenberg, A. Z., Muthuswamy, L. B., Martin, B., Lehmann, B. D., Berman, H. K., Pietenpol, J. A., Cardiff, R. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3415 · Cited by 135 · see citing works

PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression

Liu, A., Zhu, Y., Chen, W., Merlino, G. T., & Yu, Y. (2022) · Cancers · doi:10.3390/cancers14153666 · Cited by 59 · see citing works

Cell Cycle Arrest by the PTEN Tumor Suppressor Is Target Cell Specific and May Require Protein Phosphatase Activity

Hlobílková, A., Guldberg, P., Thullberg, M., et al. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4867 · Cited by 57 · see citing works

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN

Perera, N. M., Downes, C. P., Ross, S. H., et al. (2007) · Biochemical Society Symposia · doi:10.1042/bss0740069 · Cited by 23 · see citing works

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN

Downes, C. P., Perera, N. M., Ross, S. H., et al. (2007) · Biochemical Society Symposia · doi:10.1042/bss2007c07 · Cited by 19 · see citing works

Regulatory mechanisms of PTEN

Hong, J. (2009) · Basic & Clinical Medicine