PTENless means more

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

Vivanco, I., & Sawyers, C. L. (2002) · Nature reviews. Cancer · doi:10.1038/nrc839 · Cited by 6,041 · see citing works

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785 · see citing works

Wnt signaling and cancer

Polakis, P. (2000) · Genes &amp; Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E. J., Frisch, S. M., & Reed, J. C. (1998) · Science · doi:10.1126/science.282.5392.1318 · Cited by 3,118 · see citing works

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104 · see citing works

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., et al. (1997) · Nature Genetics · doi:10.1038/ng0497-356 · Cited by 2,742 · see citing works

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551 · see citing works

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

del Peso, L., González‐García, M., Page, C., Herrera, R., & Núñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 2,213 · see citing works

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacoke, M., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-64 · Cited by 2,067 · see citing works

Pten is essential for embryonic development and tumour suppression

Cristofano, A. D., Pesce, B., Cordon‐Cardo, C., & Pandolfi, P. P. (1998) · Nature Genetics · doi:10.1038/1235 · Cited by 1,518 · see citing works

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255 · see citing works

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

Tamura, M., Gu, J., Matsumoto, K., Aota, S.-I., Parsons, R., & Yamada, K. M. (1998) · Science · doi:10.1126/science.280.5369.1614 · Cited by 1,215 · see citing works

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint

Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167 · see citing works

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

Myers, M. P., Pass, I., Batty, I. H., KAAY, J. V. D., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P., & Tonks, N. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13513 · Cited by 1,161 · see citing works

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Zhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M., & Hung, M. (2001) · Nature Cell Biology · doi:10.1038/35060032 · Cited by 1,135 · see citing works

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

Biggs, W., Meisenhelder, J., Hunter, T. R., Cavenee, W. K., & Arden, K. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7421 · Cited by 1,116 · see citing works

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00215-0 · Cited by 1,109 · see citing works

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.

Lee, J.-O., Yang, H.-J., Georgescu, M., Cristofano, A. D., Maehama, T., Shi, Y., Dixon, J., Pandolfi, P., & Pavletich, N. (1999) · Cell · doi:10.1016/s0092-8674(00)81663-3 · Cited by 1,096 · see citing works

Direct control of the Forkhead transcription factor AFX by protein kinase B

Kops, G. J. P. L., de Ruiter, N. D., de Vries-Smits, A. M. M., Powell, D. R., Bos, J. L., & Burgering, B. M. T. (1999) · Nature · doi:10.1038/19328 · Cited by 1,085 · see citing works

Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

Pap, M., & Cooper, G. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.19929 · Cited by 1,046 · see citing works

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

Neshat, M. S., Mellinghoff, I. K., Tran, C., Stiles, B. L., THOMAS, G. V., Petersen, R., Frost, P., Gibbons, J. J., Wu, H., & Sawyers, C. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171076798 · Cited by 968 · see citing works

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., & Hung, M.-C. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-973 · Cited by 951 · see citing works

Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations

Weissman, I. L., Anderson, D. J., & Gage, F. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.387 · Cited by 948 · see citing works

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon‐Cardo, C., Cattoretti, G., Fisher, P. E., & Parsons, R. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1563 · Cited by 947 · see citing works

Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α

Campbell, R., Bhat-Nakshatri, P., Patel, N., Constantinidou, D., Ali, S., & Nakshatri, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010840200 · Cited by 880 · see citing works

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

Li, D. M., & Sun, H. (1997) · PubMed · Cited by 872 · see citing works

Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

Böhni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B., Beckingham, K., & Hafen, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80799-0 · Cited by 863 · see citing works

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A., Sasaki, T., Barrantes, I. D. B., Ho, A., Wakeham, A. C., ltie, A., Khoo, W., et al. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00488-5 · Cited by 819 · see citing works

Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the <i>Pten</i> Tumor Suppressor Gene in Vivo

Groszer, M., Erickson, R., Scripture-Adams, D. D., Lesche, R., Trumpp, A., Zack, J. A., Kornblum, H. I., Liu, X., & Wu, H. (2001) · Science · doi:10.1126/science.1065518 · Cited by 798 · see citing works

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

Sun, H., Lesche, R., Li, D., Liliental, J., Zhang, H., Gao, J., Gavrilova, N. J., Mueller, B., Liu, X., & Wu, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6199 · Cited by 796 · see citing works

IGF-I is required for normal embryonic growth in mice.Preprint

Powell-Braxton, L., Hollingshead, P. G., Warburton, C., Dowd, M., Pitts-Meek, S., Dalton, D. K., Gillett, N. A., & Stewart, T. A. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2609 · Cited by 795 · see citing works

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

Tang, E., Núñez, G., Barr, F. G., & Guan, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16741 · Cited by 761 · see citing works

Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis

Funamoto, S., Meili, R., Lee, S. D., Parry, L. A., & Firtel, R. (2002) · Cell · doi:10.1016/s0092-8674(02)00755-9 · Cited by 746 · see citing works

Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients

Iijima, M., & Devreotes, P. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00745-6 · Cited by 677 · see citing works

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

Wu, X., Senechal, K., Neshat, M. S., Whang, Y. E., & Sawyers, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15587 · Cited by 674 · see citing works

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

Beck, K. D., Powell-Braxtont, L., Widmer, H.-R., Valverde, J., & Hefti, F. (1995) · Neuron · doi:10.1016/0896-6273(95)90216-3 · Cited by 636 · see citing works

PTEN Mutation Spectrum and Genotype-Phenotype Correlations in Bannayan-Riley-Ruvalcaba Syndrome Suggest a Single Entity With Cowden Syndrome

Marsh, D. J., Kum, J. B., Lunetta, K. L., Bennett, M. J., Gorlin, R. J., Ahmed, S. F., Bodurtha, J. N., Crowe, C. A., Curtis, M. A., Dasouki, M., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.8.1461 · Cited by 609 · see citing works

Cowden's Disease

Lloyd, K. M., & DENNIS, M. (1963) · Annals of Internal Medicine · doi:10.7326/0003-4819-58-1-136 · Cited by 580 · see citing works

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

Crackower, M. A., Oudit, G. Y., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00969-8 · Cited by 576 · see citing works

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

Ali, I. U., Schriml, L. M., & Dean, M. C. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.22.1922 · Cited by 542 · see citing works

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

Guo, S., Rena, G., Cichy, S. B., He, X., Cohen, P., & Unterman, T. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17184 · Cited by 541 · see citing works

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

Freeman, D. J., Li, A. G., Wei, G., Li, H.-H., Kertesz, N. L., Lesche, R., Whale, A. D., Martinez-Diaz, H., Rozengurt, N., Cardiff, R. D., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00021-7 · Cited by 512 · see citing works

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

Backman, S. A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J. K., Tsao, M., Shannon, P. T., Bolon, B. N., Ivy, G. O., et al. (2001) · Nature Genetics · doi:10.1038/ng782 · Cited by 511 · see citing works

Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

Tuttle, R. L., Gill, N. S., Pugh, W., Lee, J.-P., Koeberlein, B., Furth, E. E., Polonsky, K. S., Naji, A., & Birnbaum, M. J. (2001) · Nature Medicine · doi:10.1038/nm1001-1133 · Cited by 511 · see citing works

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

Kwon, C.-H., Zhu, X., Zhang, J., Knoop, L. L., Tharp, R., Smeyne, R. J., Eberhart, C. G., Burger, P. C., & Baker, S. J. (2001) · Nature Genetics · doi:10.1038/ng781 · Cited by 478 · see citing works

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

Nakae, J., Park, B., & Accili, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.15982 · Cited by 474 · see citing works

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease

Nelen, M. R. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.8.1383 · Cited by 465 · see citing works

Phosphorylation‐dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

Lin, H.-K., Wang, L., Hu, Y., Altuwaijri, S., & Chang, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf406 · Cited by 450 · see citing works

Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten

Gu, J., Tamura, M., Pankov, R. G., Danen, E. H. J., Takino, T., Matsumoto, K., & Yamada, K. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.2.389 · Cited by 421 · see citing works

The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110α) Pathway

McMullen, J. R., Shioi, T., Huang, W., Zhang, L., Tarnavski, O., Bisping, E. H., Schinke, M., Kong, S. W., Sherwood, M. C., Brown, J. S., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310405200 · Cited by 403 · see citing works

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Lin, H.-K., Yeh, S., Kang, H.-Y., & Chang, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121173298 · Cited by 401 · see citing works

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

Verdú, J., Buratovich, M., Wilder, E., & Birnbaum, M. (1999) · Nature Cell Biology · doi:10.1038/70293 · Cited by 397 · see citing works

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

Rasheed, B., Stenzel, T. T., McLendon, R. E., Parsons, R. E., Friedman, A. H., Friedman, H. S., Bigner, D. D., & Bigner, S. H. (1997) · PubMed · Cited by 384 · see citing works

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

Anderson, K. E., Coadwell, J., Stephens, L., & Hawkins, P. T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70274-x · Cited by 360 · see citing works

Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

Raftopoulou, M., Etienne‐Manneville, S., Self, A. J., Nicholls, S., & Hall, A. (2004) · Science · doi:10.1126/science.1092089 · Cited by 335 · see citing works

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

Huang, H., Potter, C. J., Tao, W., Li, D., Brogiolo, W., Hafen, E., Sun, H., & Xu, T. (1999) · Development · doi:10.1242/dev.126.23.5365 · Cited by 321 · see citing works

The Effects of Changes in Chromosome Number on Amphibian Development

Fankhauser, G. (1945) · The Quarterly Review of Biology · doi:10.1086/394703 · Cited by 309 · see citing works

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model

Majumder, P., Yeh, J.-J., George, D., Febbo, P., Kum, J., Xue, Q., Bikoff, R., Ma, H.-K., Kantoff, P., Golub, T., et al. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1232229100 · Cited by 299 · see citing works

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

Pène, F., Claessens, Y.-É., Muller, O., Viguié, F., Mayeux, P., Dreyfus, F., Lacombe, C., & Bouscary, D. (2002) · Oncogene · doi:10.1038/sj.onc.1205923 · Cited by 294 · see citing works

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

Liliental, J., Moon, S. Y., Lesche, R., Mamillapalli, R., Li, D., Zheng, Y., Sun, H., & Wu, H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00417-6 · Cited by 290 · see citing works

PTEN, a unique tumor suppressor gene.

Dahia, P. L. M. (2000) · Endocrine Related Cancer · doi:10.1677/erc.0.0070115 · Cited by 279 · see citing works

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

Li, G., Robinson, G. W., Lesche, R., Martinez-Diaz, H., Jiang, Z., Rozengurt, N., Wagner, K.-U., Wu, D.-C., Lane, T. F., Liu, X., et al. (2002) · Development · doi:10.1242/dev.129.17.4159 · Cited by 272 · see citing works

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

Collado, M., Medema, R. H., Garcı́a-Cao, I., Dubuisson, M., Barradas, M., Glassford, J., Rivas, C., Burgering, B. M. T., Serrano, M., & Lam, E. W. ‐. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000759200 · Cited by 268 · see citing works

Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent Pathways

Gao, X., Neufeld, T. P., & Pan, D. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9680 · Cited by 260 · see citing works

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

Kwon, C.-H., Zhu, X., Zhang, J., & Baker, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2132711100 · Cited by 256 · see citing works

Regulation of β-Catenin Signaling in the Wnt Pathway

Kikuchi, A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1860 · Cited by 253 · see citing works

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

Kimura, T., Suzuki, A., Fujita, Y., Yomogida, K., Lomelı́, H., Asada, N., Ikeuchi, M., Nagy, A., Mak, T. W., & Nakano, T. (2003) · Development · doi:10.1242/dev.00392 · Cited by 244 · see citing works

Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B

Takaishi, H., Konishi, H., Matsuzaki, H., Ono, Y., Shirai, Y., Saito, N., Kitamura, T., Ogawa, W., Kasuga, M., Kikkawa, U., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11836 · Cited by 236 · see citing works

Insulin regulates the activity of forkhead transcription factor Hnf-3β/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization

Wolfrum, C., Besser, D., Luca, E., & Stoffel, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1931483100 · Cited by 209 · see citing works

Phosphorylation of HDM2 by Akt

Ashcroft, M., Ludwig, R. L., Woods, D. B., Copeland, T. D., Weber, H. O., MacRae, E. J., & Vousden, K. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205276 · Cited by 197 · see citing works

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum

Marino, S., Krimpenfort, P., Leung, C., van der Korput, H. A. G. M., Trapman, J., Camenisch, I., Berns, A. J. M., & Brandner, S. (2002) · Development · doi:10.1242/dev.129.14.3513 · Cited by 197 · see citing works

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

Mihaylova, V. T., Borland, C. Z., Manjarrez, L., Stern, M., & Sun, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7427 · Cited by 192 · see citing works

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

Munemitsu, S. M., Albert, I., Rubinfeld, B., & Polakis, P. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4088 · Cited by 186 · see citing works

Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.

Suzuki, A., Itami, S., Ohishi, M., Hamada, K., Inoue, T., Komazawa, N., Senoo, H., Sasaki, T., Takeda, J., Manabe, M., et al. (2003) · PubMed · Cited by 178 · see citing works

Germline PTEN mutations in Cowden syndrome-like families.

Marsh, D. J., Dahia, P. L. M., Caron, S., Kum, J. B., Frayling, I. M., Tomlinson, I. P. M., Hughes, K. S., Eeles, R. A., Hodgson, S. V., Murday, V. A., et al. (1998) · Journal of Medical Genetics · doi:10.1136/jmg.35.11.881 · Cited by 162 · see citing works

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

Gil, E. B., Link, E. M., Liu, L. X., Johnson, C. D., & Lees, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2925 · Cited by 155 · see citing works

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

Rouault, J.-P., Kuwabara, P. E., Sinilnikova, O. M., Duret, L., Thierry‐Mieg, D., & Billaud, M. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80143-2 · Cited by 144 · see citing works

Mammalian Target of Rapamycin: A New Molecular Target for Breast Cancer

Mita, M. M., Mita, A. C., & Rowinsky, E. K. (2003) · Clinical Breast Cancer · doi:10.3816/cbc.2003.n.018 · Cited by 143 · see citing works

Overexpression of Insulin-Like Growth Factor-II in Transgenic Mice Is Associated with Pancreatic Islet Cell Hyperplasia

Petrik, J., Pell, J. M., Arany, E. J., McDonald, T. J., Dean, W., Reik, W., & Hill, D. J. (1999) · Endocrinology · doi:10.1210/endo.140.5.6732 · Cited by 138 · see citing works

Somatic mutation of PTEN in bladder carcinoma

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Essential Role of AKT-1/Protein Kinase Bα in PTEN-Controlled Tumorigenesis

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PTEN in Neural Precursor Cells: Regulation of Migration, Apoptosis, and Proliferation

Li, L., Liu, F., Salmonsen, R. A., Turner, T. K., Litofsky, N. S., Cristofano, A. D., Pandolfi, P. P., Jones, S. N., Recht, L. D., & Ross, A. H. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1115 · Cited by 125 · see citing works

Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells.

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Physiological Functions of Pten in Mouse Tissues.

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Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells

Manin, M., Baron, S., Goossens, K., Beaudoin, C., Jean, C., VEYSSIERE, G., Verhoeven, G., & Morel, L. (2002) · Biochemical Journal · doi:10.1042/bj20020585 · Cited by 107 · see citing works

Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-β by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2

Song, K. W., Cornelius, S. C., Reiß, M., & Danielpour, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304583200 · Cited by 98 · see citing works

Breast Cancer 4

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Akt/PTEN Signaling Mediates Estrogen-Dependent Proliferation of Primordial Germ Cells in Vitro

Moe-Behrens, G. H. G., Klinger, F. G., Eskild, W., Grotmol, T., Haugen, T. B., & Felici, M. D. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0006 · Cited by 91 · see citing works

PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

Dupont, J., Renou, J., Shani, M., Hennighausen, L. G., & LeRoith, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13829 · Cited by 88 · see citing works

The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.

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Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies

Dreher, T., Zentgraf, H., Abel, U. R., Kappeler, A., Michel, M., Bleyl, U., & Grobholz, R. (2004) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-004-1004-6 · Cited by 82 · see citing works

PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

Dupont, J., Renou, J., Shani, M., Hennighausen, L. G., & LeRoith, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213829 · Cited by 79 · see citing works

Expression of the PTEN tumour suppressor protein during human development

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Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1

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Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development

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Lhermitte—Duclos disease as a component of Cowden's syndrome

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Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size

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Barraquer-Simons syndrome (with sensorineural deafness): A contribution to the differential diagnosis of lipodystrophy syndromes

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A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor.

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The Ptentative nature of mouse knockouts

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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Pten Regulates Neuronal Arborization and Social Interaction in Mice

Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Zhang, J., Grindley, J. C., Yin, T., Jayasinghe, S., He, X. C., Ross, J. T., Haug, J. S., Rupp, D., Porter-Westpfahl, K. S., Wiedemann, L. M., et al. (2006) · Nature · doi:10.1038/nature04747 · Cited by 817 · see citing works

PTEN: Tumor Suppressor and Metabolic Regulator

Chen, C.-Y., Chen, J., He, L., & Stiles, B. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00338 · Cited by 589 · see citing works

An expanding role for mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.06.007 · Cited by 519 · see citing works

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

Mulholland, D. J., Tran, L. M., Li, Y., Cai, H., Morim, A., Wang, S., Plaisier, S. B., Garraway, I. P., Huang, J., Graeber, T. G., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.006 · Cited by 516 · see citing works

Neural stem cells: balancing self-renewal with differentiation

Doe, C. Q. (2008) · Development · doi:10.1242/dev.014977 · Cited by 420 · see citing works

PTEN-deficient intestinal stem cells initiate intestinal polyposis

He, X., Yin, T., Grindley, J. C., Tian, Q., Sato, T., Tao, W. A., Dirisina, R., Porter-Westpfahl, K. S., Hembree, M. J., Johnson, T., et al. (2007) · Nature Genetics · doi:10.1038/ng1928 · Cited by 420 · see citing works

PTEN, more than the AKT pathway

Blanco‐Aparicio, C., Renner, O., Martínez-Leal, J. F., & Carnero, A. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm052 · Cited by 403 · see citing works

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

Watanabe, S., Umehara, H., Murayama, K., Okabe, M., Kimura, T., & Nakano, T. (2005) · Oncogene · doi:10.1038/sj.onc.1209307 · Cited by 351 · see citing works

The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and fibronectin

Baron, V. T., Adamson, E. D., Calogero, A., Ragona, G., & Mercola, D. (2005) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700896 · Cited by 345 · see citing works

Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?

Selman, M., Pardo, A., & Kaminski, N. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050062 · Cited by 334 · see citing works

PTEN negatively regulates neural stem cell self-renewal by modulating G ₀ -G ₁ cell cycle entry

Groszer, M., Erickson, R., Scripture-Adams, D. D., Dougherty, J. D., Le Belle, J., Zack, J. A., Geschwind, D. H., Liu, X., Kornblum, H. I., & Wu, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509939103 · Cited by 306 · see citing works

On mammary stem cells

Woodward, W. A., Chen, M. S., Behbod, F., & Rosen, J. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02532 · Cited by 274 · see citing works

The PKB/AKT Pathway in Cancer

Carnero, A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161210789941865 · Cited by 271 · see citing works

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

Gregorian, C., Nakashima, J. K., Belle, J. E. L., Ohab, J. J., Kim, R., Liu, A., Smith, K. B., Groszer, M., Garcia, A. D. R., Sofroniew, M. V., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3095-08.2009 · Cited by 265 · see citing works

New insights into PTEN

Tamgüney, T., & Stokoe, D. (2007) · Journal of Cell Science · doi:10.1242/jcs.015230 · Cited by 230 · see citing works

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models

Carnero, A., & Paramio, J. M. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00252 · Cited by 231 · see citing works

PTEN and GSK3β: key regulators of progression to androgen-independent prostate cancer

Mulholland, D. J., Dedhar, S., Wu, H., & Nelson, C. C. (2006) · Oncogene · doi:10.1038/sj.onc.1209020 · Cited by 218 · see citing works

Wnt Signaling Pathway in Mammary Gland Development and Carcinogenesis

Turashvili, G., Bouchal, J., Burkadze, G., & Kolář, Z. (2006) · Pathobiology · doi:10.1159/000098207 · Cited by 207 · see citing works

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.

Ma, X.-Q., der Made, A. C. J. Z.-V., Autar, B., van der Korput, H. A., Vermeij, M., van Duijn, P. V., Cleutjens, K., de Krijger, R. D., Krimpenfort, P., Berns, A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4519 · Cited by 204 · see citing works

Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias

Yoshimoto, M., Cutz, J., Nuin, P. A. S., Joshua, A. M., Bayani, J., Evans, A. J., Zieleńska, M., & Squire, J. A. (2006) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2006.04.003 · Cited by 181 · see citing works

Main roads to melanoma

Palmieri, G., Capone, M., Ascierto, M. L., Gentilcore, G., Stroncek, D. F., Casula, M., Sini, M. C., Palla, M., Mozzillo, N., & Ascierto, P. A. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-86 · Cited by 179 · see citing works

Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth

Ghosh-Choudhury, N., Mandal, C. C., Ghosh-Choudhury, N., & Choudhury, G. G. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2009.12.010 · Cited by 176 · see citing works

Murine Cell Lines Derived from Pten Null Prostate Cancer Show the Critical Role of PTEN in Hormone Refractory Prostate Cancer Development

Jiao, J., Wang, S., Qiao, R., Vivanco, I., Watson, P. A., Sawyers, C. L., & Wu, H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4202 · Cited by 170 · see citing works

Long-Term Self-Renewal of Postnatal Muscle-derived Stem Cells

Deasy, B. M., Gharaibeh, B., Pollett, J. B., Jones, M., Lucas, M. A., Kanda, Y., & Huard, J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0169 · Cited by 165 · see citing works

Regulation of PTEN Activity by Its Carboxyl-terminal Autoinhibitory Domain

Odriozola, L., Singh, G., Hoang, T., & Chan, A. M.-L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611240200 · Cited by 160 · see citing works

Increasing knowledge of PTEN germline mutations: Two additional patients with autism and macrocephaly

Herman, G. E., Butter, E. M., Enrile, B. G., Pastore, M., Prior, T. W., & Sommer, A. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31619 · Cited by 160 · see citing works

The role of early life genistein exposures in modifying breast cancer risk

Wärri, A. M., Saarinen, N., Mäkelä, S., & Hilakivi‐Clarke, L. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604321 · Cited by 147 · see citing works

PTEN is recruited to the postsynaptic terminal for NMDA receptor‐dependent long‐term depression

Jurado, S., Benoist, M., Lario, A., Knafo, S., Petrok, C. N., & Esteban, J. A. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.160 · Cited by 146 · see citing works

PTEN, Stem Cells, and Cancer Stem Cells

Hill, R., & Wu, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800071200 · Cited by 142 · see citing works

PI-3-K and AKT: Onto the mitochondria☆

Stiles, B. L. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.017 · Cited by 144 · see citing works

SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks

Roy, S., Luzwick, J. W., & Schlacher, K. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201709121 · Cited by 138 · see citing works

Modulation of the PI 3-kinase–Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells

Otaegi, G., Yusta-Boyo, M. J., Vergaño‐Vera, E., Méndez‐Gómez, H. R., Carrera, A. C., Abad, J. L., González, M. A., de la Rosa, E. J., Vicario‐Abejón, C., & de Pablo, F. (2006) · Journal of Cell Science · doi:10.1242/jcs.03012 · Cited by 137 · see citing works

Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer

Feigin, M. E., Akshinthala, S. D., Araki, K., Rosenberg, A. Z., Muthuswamy, L. B., Martin, B., Lehmann, B. D., Berman, H. K., Pietenpol, J. A., Cardiff, R. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3415 · Cited by 135 · see citing works

Stem Cell Self-Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto-oncogenes and Tumor SuppressorsPreprint

Pardal, R., Molofsky, A. V., He, S., & Morrison, S. J. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.057 · Cited by 131 · see citing works

Selective Deletion of Pten in Pancreatic β Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes

Stiles, B. L., Kuralwalla-Martinez, C., Guo, W., Gregorian, C., Wang, Y., Tian, J., Magnuson, M. A., & Wu, H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2772-2781.2006 · Cited by 130 · see citing works

Is Soy Consumption Good or Bad for the Breast?

Hilakivi‐Clarke, L., Andrade, J. E., & Helferich, W. G. (2010) · Journal of Nutrition · doi:10.3945/jn.110.124230 · Cited by 120 · see citing works

IPF: new insight on pathogenesis and treatment

Harari, S. A., & Caminati, A. (2010) · Allergy · doi:10.1111/j.1398-9995.2009.02305.x · Cited by 119 · see citing works

Cancer Stem Cells and the Ontogeny of Lung Cancer

Peacock, C. D., & Watkins, D. N. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.2702 · Cited by 119 · see citing works

A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination

Goebbels, S., Wieser, G. L., Pieper, A., Spitzer, S. O., Weege, B., Yan, K., Edgar, J. M., Yagensky, O., Wichert, S. P., Agarwal, A., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4425 · Cited by 118 · see citing works

Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated  -Catenin Signaling

Chen, Y., Huang, W.-C., Sejourne, J., Clipperton-Allen, A. E., & Page, D. T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5272-14.2015 · Cited by 117 · see citing works

Phosphoinositide phosphatases in cell biology and disease

Yang, L., & Bankaitis, V. A. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.12.001 · Cited by 117 · see citing works

Human Side Population Keratinocytes Exhibit Long-Term Proliferative Potential and a Specific Gene Expression Profile and Can Form a Pluristratified Epidermis

Larderet, G., Fortunel, N. O., Vaigot, P., Cegalerba, M., Maltère, P., Zobiri, O., Gidrol, X., Waksman, G., & Martin, M. T. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0196 · Cited by 116 · see citing works

miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression

Mandal, C. C., Ghosh-Choudhury, T., Dey, N., Choudhury, G. G., & Ghosh‐Choudhury, N. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs198 · Cited by 113 · see citing works

Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy

Goebbels, S., Oltrogge, J. H., Wolfer, S., Wieser, G. L., Nientiedt, T., Pieper, A. A., Ruhwedel, T., Groszer, M., Sereda, M. W., & Nave, K. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200227 · Cited by 111 · see citing works

Targeting CD133 antigen in cancer

Ferrandina, G., Petrillo, M., Bonanno, G., & Scambia, G. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903005616 · Cited by 107 · see citing works

Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and Efficacy

Mo, R. H., Zaro, J. L., & Shen, W. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200481g · Cited by 103 · see citing works

Reduced Expression of PTEN Protein and Its Prognostic Implications in Invasive Ductal Carcinoma of the Breast

Tsutsui, S., Inoue, H., Yasuda, K., Suzuki, K., Higashi, H., Era, S., & Mori, M. (2005) · Oncology · doi:10.1159/000086981 · Cited by 101 · see citing works

Fish oil targets PTEN to regulate NFκB for downregulation of anti-apoptotic genes in breast tumor growth

Ghosh-Choudhury, T., Mandal, C. C., Woodruff, K. A., Clair, P. S., Fernandes, G., Choudhury, G. G., & Ghosh‐Choudhury, N. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0227-7 · Cited by 100 · see citing works

The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN

Dave, B., Eason, R. R., Till, S. R., Geng, Y., Velarde, M. C., Badger, T. M., & Simmen, R. C. M. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi131 · Cited by 96 · see citing works

Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction

Keyes, K. T., Xu, J., Long, B., Zhang, C., Hu, Z., & Ye, Y. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00915.2009 · Cited by 96 · see citing works

Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling

Oviedo, N. J., Pearson, B. J., Levin, M. G., & Alvarado, A. S. (2008) · Disease Models & Mechanisms · doi:10.1242/dmm.000117 · Cited by 94 · see citing works

AKT signaling promotes derivation of embryonic germ cells from primordial germ cells

Kimura, T., Tomooka, M., Yamano, N., Murayama, K., Matoba, S., Umehara, H., Kanai, Y., & Nakano, T. (2008) · Development · doi:10.1242/dev.013474 · Cited by 92 · see citing works

Stem cells and brain cancer

Fomchenko, E. I., & Holland, E. C. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.03.007 · Cited by 92 · see citing works

Notch signaling in prostate cancer: A moving target

Carvalho, F. L. F., Simons, B. W., Eberhart, C. G., & Berman, D. M. (2014) · The Prostate · doi:10.1002/pros.22811 · Cited by 88 · see citing works

Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases

Miletic, A. V., Anzelon-Mills, A. N., Mills, D. M., Omori, S. A., Pedersen, I. M., Shin, D., Ravetch, J. V., Bolland, S. M., Morse, H. C., & Rickert, R. C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091962 · Cited by 87 · see citing works

Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing

Barrère‐Lemaire, S., Vincent, A., Jørgensen, C., Piot, C. A., Nargeot, J., & Djouad, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00009.2023 · Cited by 86 · see citing works

microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion

Dey, N., Das, F., Ghosh‐Choudhury, N., Mandal, C. C., Parekh, D. J., Block, K. L., Kasinath, B. S., Abboud, H. E., & Choudhury, G. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037366 · Cited by 78 · see citing works

Overview of Mouse Models of Autism Spectrum Disorders

Bey, A. L., & Jiang, Y. (2014) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0566s66 · Cited by 78 · see citing works

Basal lamina changes in neurodegenerative disorders

Nguyen, B., Bix, G., & Yao, Y. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00502-y · Cited by 75 · see citing works

Accumulating Progenitor Cells in the Luminal Epithelial Cell Layer Are Candidate Tumor Initiating Cells in a Pten Knockout Mouse Prostate Cancer Model

Korsten, H., der Made, A. Z., Ma, X., van der Kwast, T., & Trapman, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005662 · Cited by 76 · see citing works

PTEN: Local and Global Modulation of Neuronal Function in Health and Disease

Knafo, S., & Esteban, J. A. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2016.11.008 · Cited by 79 · see citing works

Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP

Zhang, D., Yang, S., Toledo, E. M., Gyllborg, D., Saltó, C., Villaescusa, J. C., & Arenas, E. (2017) · Science Signaling · doi:10.1126/scisignal.aal4165 · Cited by 74 · see citing works

Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury

Ruan, H., Li, J., Ren, S. V., Gao, J., Li, G., Kim, R., Wu, H., & Wang, Y. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.10.021 · Cited by 73 · see citing works

Transgenic Xenopus with prx1 limb enhancer reveals crucial contribution of MEK/ERK and PI3K/AKT pathways in blastema formation during limb regeneration

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The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia

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PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice

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Ex Vivo Neurogenesis within Enteric Ganglia Occurs in a PTEN Dependent Manner

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Overexpression of the Tumor Suppressor Gene Phosphatase and Tensin Homologue Partially Inhibits Wnt-1–Induced Mammary Tumorigenesis

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Creating a Pro-survival and Anti-inflammatory Phenotype by Modulation of Acetylation in Models of Hemorrhagic and Septic Shock

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PTEN Promotes Dopaminergic Neuronal Differentiation Through Regulation of ERK-Dependent Inhibition of S6K Signaling in Human Neural Stem Cells

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The role of the PI3K‐AKT kinase pathway in T‐cell development beyond the β checkpoint

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PTEN, Stem Cells, and Cancer Stem Cells

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The Role of PTEN in β-Cell Growth

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PTEN: from pathology to biology

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Genetic and cell biological aspects of PTEN in prostate cancer

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