PTEN: The down side of PI 3-kinase signalling

Mammalian MAP kinase signalling cascades

Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785 · see citing works

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes &amp; Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104 · see citing works

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., et al. (1997) · Nature Genetics · doi:10.1038/ng0497-356 · Cited by 2,742 · see citing works

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551 · see citing works

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103 · see citing works

The PI3K‒PDK1 connection: more than just a road to PKB

Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3460561 · Cited by 1,632 · see citing works

Untitled work

(2000) · PubMed · Cited by 1,445 · see citing works

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Medema, R. H., Kops, G. J. P. L., Bos, J. L., & Burgering, B. M. T. (2000) · Nature · doi:10.1038/35008115 · Cited by 1,439 · see citing works

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

Tamura, M., Gu, J., Matsumoto, K., Aota, S.-I., Parsons, R., & Yamada, K. M. (1998) · Science · doi:10.1126/science.280.5369.1614 · Cited by 1,215 · see citing works

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211 · see citing works

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

Myers, M. P., Pass, I., Batty, I. H., KAAY, J. V. D., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P., & Tonks, N. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13513 · Cited by 1,161 · see citing works

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.

Lee, J.-O., Yang, H.-J., Georgescu, M., Cristofano, A. D., Maehama, T., Shi, Y., Dixon, J., Pandolfi, P., & Pavletich, N. (1999) · Cell · doi:10.1016/s0092-8674(00)81663-3 · Cited by 1,096 · see citing works

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

Chan, T. O., Rittenhouse-Simmons, S., & Tsichlis, P. N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.965 · Cited by 981 · see citing works

Phosphoinositide 3-kinases: A conserved family of signal transducers

Vanhaesebroeck, B., Leevers, S. J., Panayotou, G., & Waterfield, M. D. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01061-x · Cited by 958 · see citing works

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., & Bourne, H. R. (2000) · Science · doi:10.1126/science.287.5455.1037 · Cited by 878 · see citing works

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

Li, D. M., & Sun, H. (1997) · PubMed · Cited by 872 · see citing works

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

Vanhaesebroeck, B., & Waterfield, M. D. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4701 · Cited by 851 · see citing works

Loss of <i>PTEN</i> facilitates HIF-1-mediated gene expression

Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., et al. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.391 · Cited by 840 · see citing works

Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers

Mutter, G. L. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.11.924 · Cited by 829 · see citing works

C2-domains, Structure and Function of a Universal Ca2+-binding Domain*

Rizo, J., & Südhof, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.15879 · Cited by 825 · see citing works

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

Sun, H., Lesche, R., Li, D., Liliental, J., Zhang, H., Gao, J., Gavrilova, N. J., Mueller, B., Liu, X., & Wu, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6199 · Cited by 796 · see citing works

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

Vázquez, F., Ramaswamy, S., Nakamura, N., & Sellers, W. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5010-5018.2000 · Cited by 777 · see citing works

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. E., & Tonks, N. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9052 · Cited by 775 · see citing works

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

Lemmon, M. A., & Ferguson, K. M. (2000) · Biochemical Journal · doi:10.1042/bj3500001 · Cited by 740 · see citing works

PTEN: Life as a Tumor Suppressor

Simpson, L., & Parsons, R. E. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5130 · Cited by 679 · see citing works

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

Leevers, S. J., Vanhaesebroeck, B., & Waterfield, M. D. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80029-5 · Cited by 678 · see citing works

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

Wu, X., Senechal, K., Neshat, M. S., Whang, Y. E., & Sawyers, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15587 · Cited by 674 · see citing works

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

Lopez-Ilasaca, M. A., Crespo, P., Pellici, P. G., Gutkind, J. S., & Wetzker, R. (1997) · Science · doi:10.1126/science.275.5298.394 · Cited by 670 · see citing works

Structure and function of phosphoinositide 3-kinases

Wymann, M. P., & Pirola, L. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00139-8 · Cited by 662 · see citing works

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

Whang, Y. E., Wu, X., Suzuki, H., Reiter, R. E., Tran, C., Vessella, R. L., SAID, J. W., Isaacs, W. B., & Sawyers, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5246 · Cited by 639 · see citing works

The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus

Torres, J., & Pulido, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009134200 · Cited by 630 · see citing works

Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27KIP1

Dijkers, P., Medema, R. H., Pals, C., Banerji, L., Thomas, N., Lam, E., Burgering, B., Raaijmakers, J., Lammers, J.-W. J., Koenderman, L., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9138-9148.2000 · Cited by 621 · see citing works

Regulation of G 1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Ramaswamy, S., Nakamura, N., Vázquez, F., Batt, D. B., Perera, S., Roberts, T. M., & Sellers, W. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2110 · Cited by 575 · see citing works

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

Nakamura, N., Ramaswamy, S., Vázquez, F., Signoretti, S., Loda, M. F., & Sellers, W. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8969-8982.2000 · Cited by 571 · see citing works

Phospholipid signaling

Divecha, N., & Irvine, R. F. (1995) · Cell · doi:10.1016/0092-8674(95)90409-3 · Cited by 568 · see citing works

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

Ali, I. U., Schriml, L. M., & Dean, M. C. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.22.1922 · Cited by 542 · see citing works

Phosphoinositide 3-kinase signalling pathways

Cantrell, D. A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1439 · Cited by 534 · see citing works

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

Jiang, B., Zheng, J. Z., Aoki, M., & Vogt, P. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040560897 · Cited by 524 · see citing works

PDZ domains in synapse assembly and signalling

Garner, C. C., Nash, J. E., & Huganir, R. L. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01783-9 · Cited by 520 · see citing works

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

DOWLER, S., Currie, R. A., CAMPBELL, D. G., Deák, M., Kular, G. S., Downes, C. P., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510019 · Cited by 516 · see citing works

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

Cristofano, A. D., Acetis, M. D., Koff, A., Cordon‐Cardo, C., & Pandolfi, P. P. (2001) · Nature Genetics · doi:10.1038/84879 · Cited by 498 · see citing works

Combinatorial control of the specificity of protein tyrosine phosphatases

Tonks, N. K., & Neel, B. G. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00196-4 · Cited by 496 · see citing works

PDZ Proteins Organize Synaptic Signaling Pathways

Craven, S. E., & Bredt, D. S. (1998) · Cell · doi:10.1016/s0092-8674(00)81179-4 · Cited by 491 · see citing works

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G 1 cell cycle arrest in human glioblastoma cells

Li, D., & Sun, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15406 · Cited by 490 · see citing works

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

Haas-Kogan, D. A., Shalev, N., Wong, M. P., Mills, G. B., Yount, G. L., & Stokoe, D. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00493-9 · Cited by 477 · see citing works

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

Fanning, A. S., & Anderson, J. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6509 · Cited by 471 · see citing works

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

Ogg, S., & Ruvkun, G. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80303-2 · Cited by 454 · see citing works

Phosphoinositide 3-kinase signalling pathways

Domin, J. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860948091_0003 · Cited by 444 · see citing works

Chemoattractant‐mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

Meili, R., Ellsworth, C., Lee, S., Reddy, T. B. K., Ma, H., & Firtel, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2092 · Cited by 441 · see citing works

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

Furnari, F. B., Lin, H., Huang, H., & Cavenee, W. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12479 · Cited by 437 · see citing works

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

Persad, S., Attwell, S., Gray, V., Delcommenne, M., Troussard, A. A., Sanghera, J. S., & Dedhar, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3207 · Cited by 428 · see citing works

Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten

Gu, J., Tamura, M., Pankov, R. G., Danen, E. H. J., Takino, T., Matsumoto, K., & Yamada, K. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.2.389 · Cited by 421 · see citing works

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

DOWLER, S., Currie, R. A., CAMPBELL, D. G., Maria, D. E. A. K., Kular, G. S., DOWNES, C. P., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3510019 · Cited by 412 · see citing works

Cellular Signaling

Toker, A., & Newton, A. C. (2000) · Cell · doi:10.1016/s0092-8674(00)00110-0 · Cited by 410 · see citing works

The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.

Furnari, F. B., Huang, H., & Cavenee, W. K. (1998) · PubMed · Cited by 399 · see citing works

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

Wu, X., Hepner, K., Castelino‐Prabhu, S., Do, D., Kaye, M. B., Yuan, X., Wood, J., Ross, C. A., Sawyers, C. L., & Whang, Y. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4233 · Cited by 398 · see citing works

Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast

Perren, A. A., Weng, L., Boag, A. H., Ziebold, U., Thakore, K. S., Dahia, P. L. M., Komminoth, P., Lees, J. A., Mulligan, L. M., Mutter, G. L., et al. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65227-3 · Cited by 379 · see citing works

The lipid phosphatase SHIP2 controls insulin sensitivity

Clément, S., Krause, U., Desmedt, F., Tanti, J., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J. M., Doherty, M., Malaisse, W. J., et al. (2001) · Nature · doi:10.1038/35051094 · Cited by 377 · see citing works

Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

Patel, L., Pass, I., Coxon, P., Downes, C. P., Smith, S. A., & Macphee, C. H. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00225-1 · Cited by 365 · see citing works

Protein kinases as mediators of phosphoinositide 3-kinase signaling.

Toker, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.4.652 · Cited by 359 · see citing works

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathwayPreprint

Goberdhan, D. C. I., Paricio, N., Goodman, E. C., Mlodzik, M., & Wilson, C. (1999) · Genes & Development · doi:10.1101/gad.13.24.3244 · Cited by 355 · see citing works

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., & Penninger, J. M. (1999) · Genes &amp; Development · doi:10.1101/gad.13.7.786 · Cited by 341 · see citing works

Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors

Gimm, O., Perren, A. A., Weng, L., Marsh, D. J., Yeh, J. J., Ziebold, U., Gil, E. B., Hinze, R., Delbridge, L., Lees, J. A., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65040-7 · Cited by 328 · see citing works

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

Huang, H., Potter, C. J., Tao, W., Li, D., Brogiolo, W., Hafen, E., Sun, H., & Xu, T. (1999) · Development · doi:10.1242/dev.126.23.5365 · Cited by 321 · see citing works

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

Georgescu, M.-M., Kirsch, K. H., Akagi, T., Shishido, T., & Hanafusa, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10182 · Cited by 318 · see citing works

The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.

Li, J., Simpson, L., Takahashi, M., et al. (1998) · PubMed · Cited by 309 · see citing works

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

Aoki, M., Blazek, E., & Vogt, P. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.136 · Cited by 306 · see citing works

Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction

Watton, S. J., & Downward, J. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80192-4 · Cited by 298 · see citing works

Structure, function, and biology of SHIP proteins

Rohrschneider, L. R., Fuller, J. F., Wolf, I., Liu, Y., & Lucas, D. M. (2000) · Genes &amp; Development · doi:10.1101/gad.14.5.505 · Cited by 294 · see citing works

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

Liliental, J., Moon, S. Y., Lesche, R., Mamillapalli, R., Li, D., Zheng, Y., Sun, H., & Wu, H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00417-6 · Cited by 290 · see citing works

PTEN, a unique tumor suppressor gene.

Dahia, P. L. M. (2000) · Endocrine Related Cancer · doi:10.1677/erc.0.0070115 · Cited by 279 · see citing works

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

Dahia, P. L. M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.185 · Cited by 270 · see citing works

Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase

Wu, Y. L., Dowbenko, D. J., Spencer, S. D., Laura, R. P., Lee, J., Gu, Q., & Lasky, L. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909741199 · Cited by 267 · see citing works

Mutation and Expression Analyses Reveal Differential Subcellular Compartmentalization of PTEN in Endocrine Pancreatic Tumors Compared to Normal Islet Cells

Perren, A. A., Komminoth, P., Saremaslani, P., Matter, C., Muletta-Feurer, S., Lees, J. A., Heitz, P. U., & Eng, C. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64624-x · Cited by 265 · see citing works

PTEN coordinates G1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

Weng, L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.6.599 · Cited by 264 · see citing works

Subcellular targeting by membrane lipids

Hurley, J. H., & Meyer, T. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00191-5 · Cited by 262 · see citing works

Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent Pathways

Gao, X., Neufeld, T. P., & Pan, D. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9680 · Cited by 260 · see citing works

Genetic control of cell size.

Stocker, H., & Hafen, E. (2000) · Current Opinion in Genetics and Development · doi:10.1016/s0959-437x(00)00123-4 · Cited by 257 · see citing works

Adenovirus Endocytosis via α v Integrins Requires Phosphoinositide-3-OH Kinase

Li, E., Stupack, D. G., Klemke, R. L., Cheresh, D. A., & Nemerow, G. R. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2055-2061.1998 · Cited by 250 · see citing works

PTEN controls tumor-induced angiogenesis

Wen, S., Stolarov, J. P., Myers, M. P., Su, J. D., Wigler, M. H., Tonks, N. K., & Durden, D. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081063798 · Cited by 242 · see citing works

Constitutive Macropinocytosis in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C

Amyere, M., Payrastre, B., Krause, U., Smissen, P. V. D., Veithen, A., & Courtoy, P. J. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3453 · Cited by 233 · see citing works

A Role for Nuclear PTEN in Neuronal Differentiation

Lachyankar, M. B., Sultana, N. A., Schonhoff, C. M., Mitra, P., Poluha, W., Lambert, S., Quesenberry, P. J., Litofsky, N. S., Recht, L. D., Nabi, R. R., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01404.2000 · Cited by 231 · see citing works

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27KIP1 through the ubiquitin E3 ligase SCFSKP2

Mamillapalli, R., Gavrilova, N. J., Mihaylova, V. T., Tsvetkov, L. M., Wu, H., Zhang, H., & Sun, H. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00065-3 · Cited by 224 · see citing works

The role of PI 3-kinase in insulin action

Alessi, D. R., & Downes, C. P. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00133-7 · Cited by 219 · see citing works

The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes

Nakashima, N., Sharma, P. M., Imamura, T., Bookstein, R., & Olefsky, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12889 · Cited by 194 · see citing works

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

Mihaylova, V. T., Borland, C. Z., Manjarrez, L., Stern, M., & Sun, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7427 · Cited by 192 · see citing works

5′ Phospholipid Phosphatase SHIP-2 Causes Protein Kinase B Inactivation and Cell Cycle Arrest in Glioblastoma Cells

Taylor, V., Wong, M. P., Brandts, C., Reilly, L., Dean, N. M., Cowsert, L. M., Moodie, S. A., & Stokoe, D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6860-6871.2000 · Cited by 182 · see citing works

Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.

Georgescu, M. M., Kirsch, K. H., Kaloudis, P., Yang, H., Pavletich, N. P., & Hanafusa, H. (2000) · PubMed · Cited by 176 · see citing works

Receptor Tyrosine Kinases

Simon, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00100-8 · Cited by 168 · see citing works

Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.

Han, S., Kato, H., Kato, S., Suzuki, T., Shibata, H., Ishii, S., Shiiba, K.-I., Matsuno, S., Kanamaru, R., & Ishioka, C. (2000) · PubMed · Cited by 158 · see citing works

Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.

Adey, N. B., Huang, L., Ormonde, P. A., Baumgard, M. L., Pero, R. S., Byreddy, D. V., Tavtigian, S. V., & Bartel, P. L. (2000) · PubMed · Cited by 158 · see citing works

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

Gil, E. B., Link, E. M., Liu, L. X., Johnson, C. D., & Lees, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2925 · Cited by 155 · see citing works

Phospholipid signalling in the nucleus

D’Santos, C. S., Clarke, J. H., & Divecha, N. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00146-5 · Cited by 152 · see citing works

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

Rouault, J.-P., Kuwabara, P. E., Sinilnikova, O. M., Duret, L., Thierry‐Mieg, D., & Billaud, M. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80143-2 · Cited by 144 · see citing works

Phosphoinositide Binding Domains

Fruman, D. A., Rameh, L. E., & Cantley, L. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80792-8 · Cited by 129 · see citing works

Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins

Kim, S. K. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80088-9 · Cited by 129 · see citing works

Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling

JACKSON, T. R., Kearns, B. G., & Theibert, A. B. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01644-3 · Cited by 129 · see citing works

Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

Leslie, N. R., Biondi, R. M., & Alessi, D. R. (2001) · Chemical Reviews · doi:10.1021/cr000091i · Cited by 121 · see citing works

Signals to Move Cells

Dekker, L. V., & Segal, A. W. (2000) · Science · doi:10.1126/science.287.5455.982 · Cited by 112 · see citing works

Untitled work

Hinchliffe (1998) · doi:10.1016/s0005-2760(98)00140-4 · Cited by 110 · see citing works

p27Kip1 is required for PTEN-induced G1 growth arrest.

GOTTSCHALK, A. R., Basila, D., Wong, M., et al. (2001) · PubMed · Cited by 104 · see citing works

Insulin-like Growth Factor I Stimulates Tyrosine Phosphorylation of p130Cas, Focal Adhesion Kinase, and Paxillin

Casamassima, A., & Rozengurt, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26149 · Cited by 100 · see citing works

Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.

Matsushima-Nishiu, M., Unoki, M., Ono, K., Tsunoda, T., Minaguchi, T., Kuramoto, H., Nishida, M., Satoh, T., Tanaka, T., & Nakamura, Y. (2001) · PubMed · Cited by 89 · see citing works

Do growth and cell division rates determine cell size in multicellular organisms?

Coelho, C. M. A., & Leevers, S. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.17.2927 · Cited by 81 · see citing works

Novel vitamin D3 analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D3, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

Hisatake, J., O’Kelly, J., Uskoković, M. R., Tomoyasu, S., & Koeffler, H. P. (2001) · Blood · doi:10.1182/blood.v97.8.2427 · Cited by 81 · see citing works

A testis-specific gene, TPTE , encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y

Chen, H., Rossier, C., Morris, M. A., Scott, H. S., Gos, A., Bairoch, A., & Antonarakis, S. E. (1999) · Human Genetics · doi:10.1007/s004390051122 · Cited by 74 · see citing works

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

Leslie, N. R., Alex, G. R. A. Y., Pass, I., Orchiston, E. A., & Downes, C. P. (2000) · Biochemical Journal · doi:10.1042/bj3460827 · Cited by 73 · see citing works

PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2

Simpson, L., Li, J., Liaw, D., Hennessy, I., Oliner, J. D., Christians, F. C., & Parsons, R. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3947-3958.2001 · Cited by 68 · see citing works

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

Tolkacheva, T., & Chan, A. M.-L. (2000) · Oncogene · doi:10.1038/sj.onc.1203331 · Cited by 63 · see citing works

Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes

Gelb, M. H., Min, J.-H., & Jain, M. K. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00106-2 · Cited by 59 · see citing works

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

Leslie, N. R., Bennett, D., Alex, G. R. A. Y., et al. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570427 · Cited by 53 · see citing works

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

Leslie, N. R., Bennett, D., Alex, G. R. A. Y., et al. (2001) · Biochemical Journal · doi:10.1042/bj3570427 · Cited by 49 · see citing works

Characterization of 11 new mutations inCOL3A1 of individuals with Ehlers-Danlos syndrome type IV: Preliminary comparison of RNase cleavage, EMC and DHPLC assays

Giunta, C., & Steinmann, B. U. (2000) · Human Mutation · doi:10.1002/1098-1004(200008)16:2 · Cited by 26 · see citing works

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Ros and ros-mediated cellular signaling

Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980 · see citing works

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

Nagata, Y., Lan, K.-H., Zhou, X., Tan, M., Esteva, F. J., Sahin, A. A., Klos, K. S., Li, P., Monia, B. P., Nguyen, N. T., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.022 · Cited by 1,858 · see citing works

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer’s disease pathology

Griffin, R. J., Moloney, A., Kelliher, M., Johnston, J. A., Ravid, R., Dockery, P., O'Connor, R., & O'Neill, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02949.x · Cited by 459 · see citing works

Differential impact of mammalian target of rapamycin inhibition on CD4 +CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

Zeiser, R., Leveson-Gower, D. B., Zambricki, E. A., Kambham, N., Beilhack, A., Loh, J., Hou, J.-Z., & Negrin, R. S. (2008) · Blood · doi:10.1182/blood-2007-06-094482 · Cited by 402 · see citing works

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD

Tramutola, A., Triplett, J. C., Di Domenico, F., Niedowicz, D. M., Murphy, M. P., Coccia, R., Perluigi, M., & Butterfield, D. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13037 · Cited by 347 · see citing works

PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression

Liu, A., Zhu, Y., Chen, W., Merlino, G. T., & Yu, Y. (2022) · Cancers · doi:10.3390/cancers14153666 · Cited by 62 · see citing works

Cell Cycle Arrest by the PTEN Tumor Suppressor Is Target Cell Specific and May Require Protein Phosphatase Activity

Hlobílková, A., Guldberg, P., Thullberg, M., et al. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4867 · Cited by 57 · see citing works

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN

Perera, N. M., Downes, C. P., Ross, S. H., et al. (2007) · Biochemical Society Symposia · doi:10.1042/bss0740069 · Cited by 23 · see citing works

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN

Downes, C. P., Perera, N. M., Ross, S. H., et al. (2007) · Biochemical Society Symposia · doi:10.1042/bss2007c07 · Cited by 19 · see citing works

Regulatory mechanisms of PTEN

Hong, J. (2009) · Basic & Clinical Medicine