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Cited by 469

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype

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Li, Amy, Simmons, Paul J., Kaur, Pritinder·1998·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.95.7.3902
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Abstract

Despite the central role of human epidermal stem cells in tissue homeostasis, wound repair, and neoplasia, remarkably little is known about these cells, largely due to the absence of molecular markers that distinguish them from other proliferative cells within the germinative/basal layer. Epidermal stem cells can be distinguished from other cells in the basal layer by their quiescent nature in vivo and their greater overall proliferative capacity. In this study, we demonstrate enrichment and isolation of a subpopulation of basal epidermal cells from neonatal human foreskin based on cell surface phenotype, which satisfy these criteria. These putative stem cells are distinguished from other basal cells by their characteristic expression of high levels of the adhesion molecule α 6, a member of the integrin family (α 6bri), and low levels of a proliferation-associated cell surface marker recognized by recently described mAb 10G7 (10G7 dim). We conclude that cells with the phenotype α 6bri 10G7 dim represent the epidermal stem cell population based on the demonstration that these cells (i) exhibit the greatest regenerative capacity of any basal cells, (ii) represent a minor subpopulation (≈10%) of immature epidermal cells, which (iii) are quiescent at the time of isolation from the epidermis, as determined by cell cycle analysis.

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Metadata

Authors
Li, A., Simmons, P. J., & Kaur, P.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1998-03-31
Volume
95
Issue
7
Pages
3902-3907
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.95.7.3902
OpenAlex
W2077107241
Cited by
469
References
32
FWCI
14.41
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. https://app.cochat.ai/papers/10.1073/pnas.95.7.3902
The paper
Li, A., Simmons, P. J., & Kaur, P. (1998). Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.7.3902

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.