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Cited by 543

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

The roles of prefrontal brain regions in components of working memory: Effects of memory load and individual differences

Open access
Rypma, Bart, D’Esposito, Mark·1999·Proceedings of the National Academy of Sciences

Abstract

Using an event-related functional MRI design, we explored the relative roles of dorsal and ventral prefrontal cortex (PFC) regions during specific components (Encoding, Delay, Response) of a working memory task under different memory-load conditions. In a group analysis, effects of increased memory load were observed only in dorsal PFC in the encoding period. Activity was lateralized to the right hemisphere in the high but not the low memory-load condition. Individual analyses revealed variability in activation patterns across subjects. Regression analyses indicated that one source of variability was subjects’ memory retrieval rate. It was observed that dorsal PFC plays a differentially greater role in information retrieval for slower subjects, possibly because of inefficient retrieval processes or a reduced quality of mnemonic representations. This study supports the idea that dorsal and ventral PFC play different roles in component processes of working memory.

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Crossref · 10.1073/pnas.96.11.6558

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Citations

Cites

Research works printed but not linked: 26

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Metadata

Authors
Rypma, B., & D’Esposito, M.
Venue
Proceedings of the National Academy of Sciences
Published
1999-05-25
Volume
96
Issue
11
Pages
6558-6563
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2108009185
Cited by
543
References
9
FWCI
10.34
Type
journal article
Language
en
Open access
green

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