MYC: Connecting selective transcriptional control to global RNA production

Molecular Cell Biology

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Identification of c- <i>MYC</i> as a Target of the APC Pathway

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MYC on the Path to Cancer

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CpG islands and the regulation of transcription

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

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Reflecting on 25 years with MYC

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Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

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Transcriptional Amplification in Tumor Cells with Elevated c-Myc

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Emerging landscape of oncogenic signatures across human cancers

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

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Widespread microRNA repression by Myc contributes to tumorigenesis

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An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells

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c-Myc Regulates Transcriptional Pause Release

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The Many Pathways of RNA Degradation

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Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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Molecular cell biology

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Transcriptional regulation and transformation by Myc proteins

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c-Myc transactivation of <i>LDH-A</i> : Implications for tumor metabolism and growth

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c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

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Context-dependent control of alternative splicing by RNA-binding proteins

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Genomic targets of the human c-Myc proteinPreprint

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MYC as a regulator of ribosome biogenesis and protein synthesis

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Myc’s broad reach

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Reversible tumorigenesis by MYC in hematopoietic lineages.

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Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

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Getting up to speed with transcription elongation by RNA polymerase II

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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

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Modelling Myc inhibition as a cancer therapy

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

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Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factorsPreprint

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MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint

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Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

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myc FUNCTION AND REGULATION

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Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

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RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo

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An expansive human regulatory lexicon encoded in transcription factor footprints

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Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes

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Metabolic Regulation of Epigenetics

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

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Non-transcriptional control of DNA replication by c-Myc

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Drosophila myc Regulates Cellular Growth during Development

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Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

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CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

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Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

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Revisiting Global Gene Expression Analysis

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Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

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Myc deletion rescues Apc deficiency in the small intestine

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MYC, Metabolism, Cell Growth, and TumorigenesisPreprint

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Repression of p15INK4b expression by Myc through association with Miz-1

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The Myc oncoprotein as a therapeutic target for human cancer

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X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA

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Global mapping of c-Myc binding sites and target gene networks in human B cells

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Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

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The spliceosome is a therapeutic vulnerability in MYC-driven cancer

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TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

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An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

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Bim is a suppressor of Myc-induced mouse B cell leukemia

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E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

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Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

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Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations

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Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAsPreprint

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The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements

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Ras Enhances Myc Protein Stability

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

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Myc represses transcription through recruitment of DNA methyltransferase corepressor

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The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

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Direct activation of RNA polymerase III transcription by c-Myc

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Single Mammalian Cells Compensate for Differences in Cellular Volume and DNA Copy Number through Independent Global Transcriptional Mechanisms

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The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

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mRNAs containing extensive secondary structure in their 5′ non‐coding region translate efficiently in cells overexpressing initiation factor eIF‐4E.

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Myc represses the p21 (WAF1/CIP1) promoter and interacts with Sp1/Sp3

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Control of Transcriptional Elongation

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MYC recruits the TIP60 histone acetyltransferase complex to chromatin

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STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

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Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor networkPreprint

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Myc influences global chromatin structure

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MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

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Myc-binding-site recognition in the human genome is determined by chromatin context

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

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Nonsense-mediated mRNA decay — Mechanisms of substrate mRNA recognition and degradation in mammalian cells

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Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1

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Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

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New cell cycle compartments identified by multiparameter flow cytometry

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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

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Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29

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Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

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Control of cell growth by c-Myc in the absence of cell division

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Repression of transcription of the p27Kip1 cyclin-dependent kinase inhibitor gene by c-Myc

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Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc

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Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc

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Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis

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Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

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Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

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Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.

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An Essential E Box in the Promoter of the Gene Encoding the mRNA Cap-Binding Protein (Eukaryotic Initiation Factor 4E) Is a Target for Activation by c-myc

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Eukaryotic Initiation Factor 6 is rate-limiting in translation, growth and transformation

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Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15Ink4B

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Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15Ink4b G1 Arrest Pathway

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Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes

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Transforming Growth Factor β-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

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Apoptosis Triggered by Myc-Induced Suppression of Bcl-X L or Bcl-2 Is Bypassed during Lymphomagenesis

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The c‐myc Promoter: Still MysterY and Challenge

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Myc‐induced proliferation and transformation require Akt‐mediated phosphorylation of FoxO proteins

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Coordinating genome expression with cell size

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Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

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Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

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A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

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CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaPreprint

Huang, C., Lujambio, A., Zuber, J. A., Tschaharganeh, D. F., Doran, M. G., Evans, M. J., Kitzing, T. M., Zhu, N., de Stanchina, E., Sawyers, C. L., et al. (2014) · Genes & Development · doi:10.1101/gad.244368.114 · Cited by 201 · see citing works

A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

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The eukaryotic RNA exosome

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MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation

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Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

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Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

Mao, D. Y. L., Watson, J. D., Yan, P. S., Baršytė-Lovejoy, D., Khosravi, F., Wong, W. W.-L., Farnham, P., Huang, T. H. ‐., & Penn, L. Z. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00297-5 · Cited by 183 · see citing works

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

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Endogenous Myc maintains the tumor microenvironmentPreprint

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Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters

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Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition

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An E-Box-Mediated Increase in cad Transcription at the G1/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

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AREsite: a database for the comprehensive investigation of AU-rich elements

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Large-Scale Identification of c-MYC-Associated Proteins Using a Combined TAP/MudPIT Approach

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Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

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Bax is a transcriptional target and mediator of c-myc-induced apoptosis.

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c-myc protein expression in untransformed fibroblasts.

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Global target mRNA specification and regulation by the RNA-binding protein ZFP36

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Mammalian MYC Proteins and Cancer

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Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry

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The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain Independently of Direct DNA Binding

Cowling, V. H., & Cole, M. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01828-06 · Cited by 150 · see citing works

Conditional transgenic models define how MYC initiates and maintains tumorigenesis

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The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis

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Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cellsPreprint

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Taming of the beast: shaping Myc-dependent amplification

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Connecting Variability in Global Transcription Rate to Mitochondrial Variability

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Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5APreprint

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Transcriptional Repression: The Dark Side of Myc

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A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition

Smith, A. P., Verrecchia, A., Fagà, G., Doni, M., Perna, D., Martinato, F., Guccione, E., & Amati, B. B. (2008) · Oncogene · doi:10.1038/onc.2008.395 · Cited by 128 · see citing works

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X L

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Myc and its interactors take shape

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c-MYC-Induced Genomic InstabilityPreprint

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Tristetraprolin Impairs Myc-Induced Lymphoma and Abolishes the Malignant State

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Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

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Induction of cyclin E–cdk2 kinase activity, E2F‐dependent transcription and cell growth by Myc are genetically separable events

Beier, R., Bürgin, A., Kiermaier, A. C., Fero, M. L., Karsunky, H., Saffrich, R., Möröy, T., Ansorge, W. J., Roberts, J., & Eilers, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5813 · Cited by 114 · see citing works

MicroRNAs as regulators and mediators of c-MYC function

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Genome Recognition by MYCPreprint

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Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma

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Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts

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The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenancePreprint

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Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation.

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Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

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Regulation of Cyclin D1 RNA Stability by SNIP1

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c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells

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Myc Regulates the Transcription of the PRC2 Gene To Control the Expression of Developmental Genes in Embryonic Stem Cells

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P-TEFb is a Crucial Co-Factor for Myc Transactivation

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Myc and SAGA rewire an alternative splicing network during early somatic cell reprogrammingPreprint

Hirsch, C. L., Coban‐Akdemir, Z., Wang, L., Jayakumaran, G., Trcka, D., Weiss, A., Hernández, J. J., Pan, Q., Han, H. R., Xu, X., et al. (2015) · Genes & Development · doi:10.1101/gad.255109.114 · Cited by 85 · see citing works

Sequence specificity incompletely defines the genome-wide occupancy of Myc

Guo, J., Li, T., Schipper, J. L., Nilson, K. A., Fordjour, F. K., Cooper, J. J., Gordân, R., & Price, D. H. (2014) · Genome biology · doi:10.1186/s13059-014-0482-3 · Cited by 84 · see citing works

MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase

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MYC regulates the non-coding transcriptome

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Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc

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Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors

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lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

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Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

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Lipid metabolism in cancer progression and therapeutic strategies

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SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

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Target gene-independent functions of MYC oncoproteins

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

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LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

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Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

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MYC and tumor metabolism: chicken and egg

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Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

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Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk

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Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

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Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

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Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

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MYC—Master Regulator of the Cancer Epigenome and Transcriptome

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c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment

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Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

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Functionally diverse human T cells recognize non-microbial antigens presented by MR1

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Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

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Different promoter affinities account for specificity in MYC-dependent gene regulation

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Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC

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BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis

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Pluripotency and the origin of animal multicellularity

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Mission Possible: Advances in MYC Therapeutic Targeting in Cancer

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MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

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More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer

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The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer

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Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

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Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

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MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

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Concise Review: Control of Cell Fate Through Cell Cycle and Pluripotency Networks

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Advances in targeted therapy for malignant lymphoma

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Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

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Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc

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Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma

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Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

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Targeting MYC in multiple myeloma

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A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation

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DAXX in cancer: phenomena, processes, mechanisms and regulation

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MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

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Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

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The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

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MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression

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Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation

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MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels

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Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

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Single-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation

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OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

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MYC and therapy resistance in cancer: risks and opportunities

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Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

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An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

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MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma

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Targeting MYCN in Pediatric and Adult Cancers

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Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas

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MYC multimers shield stalled replication forks from RNA polymerase

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Downregulation of ribosome biogenesis during early forebrain development

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CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

Pulikkan, J. A., Hegde, M. B., Ahmad, H. M., Belaghzal, H., Illendula, A., Yu, J., O’Hagan, K., Ou, J., Müller‐Tidow, C., Wolfe, S. A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.048 · Cited by 91 · see citing works

Regulatory mechanisms of PD-L1 expression in cancer cells

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SUMO protease SENP1 deSUMOylates and stabilizes c-Myc

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MYC Modulation around the CDK2/p27/SKP2 Axis

Hydbring, P., Castell, A., & Larsson, L. (2017) · Genes · doi:10.3390/genes8070174 · Cited by 90 · see citing works

LAST, a c-Myc-inducible long noncoding RNA, cooperates with CNBP to promote CCND1 mRNA stability in human cells

Cao, L., Zhang, P., Li, J., & Wu, M. (2017) · eLife · doi:10.7554/elife.30433 · Cited by 90 · see citing works

Molecular Crosstalk Between MYC and HIF in Cancer

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Transcriptional integration of mitogenic and mechanical signals by Myc and YAPPreprint

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Drugging “undruggable” genes for cancer treatment: Are we making progress?

Duffy, M. J., & Crown, J. P. (2020) · International Journal of Cancer · doi:10.1002/ijc.33197 · Cited by 85 · see citing works

MYC amplifies gene expression through global changes in transcription factor dynamics

Patange, S., Ball, D. A., Wan, Y., Karpova, T., Girvan, M., Levens, D., & Larson, D. R. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110292 · Cited by 86 · see citing works

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

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MYC and HIF in shaping immune response and immune metabolism

Gnanaprakasam, J. R., Sherman, J. W., & Wang, R. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.03.004 · Cited by 84 · see citing works

Concepts to Target MYC in Pancreatic Cancer

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MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?

Zhang, T., Li, N., Sun, C., Jin, Y., & Sheng, X. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911845 · Cited by 82 · see citing works

Targeting MYC in cancer therapy: RNA processing offers new opportunities

Koh, C. M., Sabò, A., & Guccione, E. (2016) · BioEssays · doi:10.1002/bies.201500134 · Cited by 79 · see citing works

A Time for MYC: Metabolism and TherapyPreprint

Dang, C. V. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.031153 · Cited by 78 · see citing works

Human MYC G-quadruplex: From discovery to a cancer therapeutic target

Wang, W., Hu, S., Gu, Y., Yan, Y., Stovall, D. B., Li, D., & Sui, G. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188410 · Cited by 77 · see citing works

MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer

Casacuberta‐Serra, S., González-Larreategui, Í., Capitán-Leo, D., & Soucek, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01907-z · Cited by 80 · see citing works

Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

Hayashi, K., & Anzai, N. (2017) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v9.i1.21 · Cited by 76 · see citing works

Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets

Maharjan, C. K., Ear, P. H., Tran, C. G., Howe, J. R., Chandrasekharan, C., & Quelle, D. E. (2021) · Cancers · doi:10.3390/cancers13205117 · Cited by 75 · see citing works

The role of circadian clock genes in tumors

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Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

Annunziato, S., de Ruiter, J. R., Henneman, L., Brambillasca, C. S., Lutz, C., Vaillant, F., Ferrante, F., Drenth, A. P., van der Burg, E., Siteur, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08301-2 · Cited by 69 · see citing works

An early Myc‐dependent transcriptional program orchestrates cell growth during B‐cell activation

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The MYC mRNA 3′‐UTR couples RNA polymerase II function to glutamine and ribonucleotide levels

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Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma

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c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3

Ma, H., Zhang, J., Zhou, L., Wen, S., Tang, H.-Y., Jiang, B., Zhang, F., Suleman, M., Sun, D., Chen, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.005 · Cited by 68 · see citing works

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake

Zhang, P., Wang, Q., Lin, Z., Yang, P., Dou, K., & Zhang, R. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s235667 · Cited by 68 · see citing works

Dissecting transcriptional amplification by MYC

Nie, Z., Guo, C., Das, S., Chow, C. C., Batchelor, E., Simons, S. S., & Levens, D. (2020) · eLife · doi:10.7554/elife.52483 · Cited by 68 · see citing works

Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma

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Oncogene-regulated release of extracellular vesicles

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MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sitesPreprint

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The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas

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Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signalsPreprint

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Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

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Fine-tuned amplification in cells

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MYC function and regulation in physiological perspective

Jha, R., Kouzine, F., & Levens, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1268275 · Cited by 106 · see citing works

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Walz, S., Lorenzin, F., Morton, J. P., Wiese, K. E., von Eyß, B., Herold, S., Rycak, L., Dumay‐Odelot, H., Karim, S. A., Bartkuhn, M., et al. (2014) · Nature · doi:10.1038/nature13473 · Cited by 502 · see citing works

Measuring MYC-Mediated Metabolism in Tumorigenesis

Tang, H., Goldman, A. R., Zhang, X., Speicher, D. W., & Dang, C. V. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1476-1_11 · Cited by 10 · see citing works