The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
Open accessAbstract
To study the physiological and molecular mechanisms of age-related memory loss, we assessed spatial memory in C57BL/B6 mice from different age cohorts and then measured in vitro the late phase of hippocampal long-term potentiation (L-LTP). Most young mice acquired the spatial task, whereas only a minority of aged mice did. Aged mice not only made significantly more errors but also exhibited greater individual differences. Slices from the hippocampus of aged mice exhibited significantly reduced L-LTP, and this was significantly and negatively correlated with errors in memory. Because L-LTP depends on cAMP activation, we examined whether drugs that enhanced cAMP would attenuate the L-LTP and memory defects. Both dopamine D1/D5 receptor agonists, which are positively coupled to adenylyl cyclase, and a cAMP phosphodiesterase inhibitor ameliorated the physiological as well as the memory defects, consistent with the idea that a cAMP–protein kinase A-dependent signaling pathway is defective in age-related spatial memory loss.
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Cites
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The hippocampal-VTA loop: controlling the entry of information into long-term memory
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Metadata
- Authors
- Bach, M. E., Barad, M., Son, H., Zhuo, M., Lu, Y.-F., Shih, R., Mansuy, I., Hawkins, R. D., & Kandel, E. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-04-27
- Volume
- 96
- Issue
- 9
- Pages
- 5280-5285
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052884971
- Cited by
- 560
- References
- 38
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Bach, M. E., Barad, M., Son, H., Zhuo, M., Lu, Y.-F., Shih, R., Mansuy, I., Hawkins, R. D., & Kandel, E. R. (1999). Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.9.5280
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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