Cited by 568Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty

Li, Shaomin, Cullen, William K., Anwyl, Roger, Rowan, Michael J.·2003·Nature Neuroscience

Abstract

In addition to its role in memory formation, the hippocampus may act as a novelty detector. Here we investigated whether attention to novel events can promote the associative synaptic plasticity mechanisms believed to be necessary for storing those events in memory. We therefore examined whether exposure to a novel spatial environment promoted the induction of activity-dependent persistent increases in glutamatergic transmission (long-term potentiation, LTP) at CA1 synapses in the rat hippocampus. We found that brief exposure to a novel environment lowered the threshold for the induction of LTP. This facilitatory effect was present for a short period following novelty exposure but was absent in animals that explored a familiar environment. Furthermore, the facilitation was dependent on activation of D1/D5 receptors. These findings support an important role for dopamine-regulated synaptic plasticity in the storage of unpredicted information in the CA1 area.

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Crossref · 10.1038/nn1049

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48 of 48 references verified0 citation errors · 0 not checkable

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  • A variety of arousing experiences, such as water immersion, exposure to novel places and objects, and spatial learning occurring around the time of the delivery of tetanizing stimulation, all increased the duration of LTP in CA1 and DG.

    “Numerous other studies have replicated and extended this finding to show that a variety of arousing experiences, such as water immersion, exposure to novel places and objects, and spatial learning occurring around the time of the delivery of tetanizing stimulation, all increased the duration of LTP in CA1 and DG (e.g., Seidenbecher et al. [202]; Frey [203]; Li et al. [204]; Straube et al. [205];”
  • Blockade of D1/D5 dopaminergic receptors during exploration of novel environments prevents novelty-facilitated synaptic plasticity.

    “and also prevents novelty-facilitated synaptic plasticity9.”
  • Our results provide novel insights into the relationship between midbrain dopaminergic neurons, encoding salient information about an environment, and hippocampal assemblies, providing representations of space, in modulating memory according to the value of the information to be remembered.

    “Our results thus provide novel insights into the relationship between midbrain dopaminergic neurons, encoding salient information about an environment9,10,16,19,20, and hippocampal assemblies, providing representations of space1-3, in modulating memory according to the value of the information to be remembered.”
  • Pharmacological studies have implicated the neurotransmitter dopamine in the stability of hippocampus-dependent memory.

    “Pharmacological studies have implicated the neurotransmitter dopamine in the stability of hippocampus-dependent memory.”

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Authors
Li, S., Cullen, W. K., Anwyl, R., & Rowan, M. J.
Affiliations
Trinity College Dublin (IE)
Corresponding author
Rowan, Michael J.
Venue
Nature Neuroscience
Published
2003-04-21
Volume
6
Issue
5
Pages
526-531
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1982771150
Cited by
568
References
48
Citations by year
2026: 12 · 2025: 22 · 2024: 41 · 2023: 17 · 2022: 18 · 2021: 30 · 2020: 22 · 2019: 21 · 2018: 28 · 2017: 24 · 2016: 24 · 2015: 31 · 2014: 31 · 2013: 23 · 2012: 24
FWCI
9.65
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
dopamine, long-term potentiation, hippocampal CA1, spatial novelty, novelty detection, synaptic plasticity, glutamatergic neurotransmission, memory formation
MeSH terms
Animals, Exploratory Behavior, Hippocampus, Male, Neurons, Receptors, Dopamine, Spatial Behavior, Rats, Wistar, Receptors, Dopamine D1, Long-Term Potentiation, Receptors, Dopamine D5, Rats

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