Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty
Abstract
In addition to its role in memory formation, the hippocampus may act as a novelty detector. Here we investigated whether attention to novel events can promote the associative synaptic plasticity mechanisms believed to be necessary for storing those events in memory. We therefore examined whether exposure to a novel spatial environment promoted the induction of activity-dependent persistent increases in glutamatergic transmission (long-term potentiation, LTP) at CA1 synapses in the rat hippocampus. We found that brief exposure to a novel environment lowered the threshold for the induction of LTP. This facilitatory effect was present for a short period following novelty exposure but was absent in animals that explored a familiar environment. Furthermore, the facilitation was dependent on activation of D1/D5 receptors. These findings support an important role for dopamine-regulated synaptic plasticity in the storage of unpredicted information in the CA1 area.
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A variety of arousing experiences, such as water immersion, exposure to novel places and objects, and spatial learning occurring around the time of the delivery of tetanizing stimulation, all increased the duration of LTP in CA1 and DG.
“Numerous other studies have replicated and extended this finding to show that a variety of arousing experiences, such as water immersion, exposure to novel places and objects, and spatial learning occurring around the time of the delivery of tetanizing stimulation, all increased the duration of LTP in CA1 and DG (e.g., Seidenbecher et al. [202]; Frey [203]; Li et al. [204]; Straube et al. [205];”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Li et al. [204]
Blockade of D1/D5 dopaminergic receptors during exploration of novel environments prevents novelty-facilitated synaptic plasticity.
“and also prevents novelty-facilitated synaptic plasticity9.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [9]
Our results provide novel insights into the relationship between midbrain dopaminergic neurons, encoding salient information about an environment, and hippocampal assemblies, providing representations of space, in modulating memory according to the value of the information to be remembered.
“Our results thus provide novel insights into the relationship between midbrain dopaminergic neurons, encoding salient information about an environment9,10,16,19,20, and hippocampal assemblies, providing representations of space1-3, in modulating memory according to the value of the information to be remembered.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [9]
Pharmacological studies have implicated the neurotransmitter dopamine in the stability of hippocampus-dependent memory.
“Pharmacological studies have implicated the neurotransmitter dopamine in the stability of hippocampus-dependent memory.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [9]
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- Authors
- Li, S., Cullen, W. K., Anwyl, R., & Rowan, M. J.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Rowan, Michael J.
- Venue
- Nature Neuroscience
- Published
- 2003-04-21
- Volume
- 6
- Issue
- 5
- Pages
- 526-531
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1982771150
- Cited by
- 568
- References
- 48
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 41 · 2023: 17 · 2022: 18 · 2021: 30 · 2020: 22 · 2019: 21 · 2018: 28 · 2017: 24 · 2016: 24 · 2015: 31 · 2014: 31 · 2013: 23 · 2012: 24
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- dopamine, long-term potentiation, hippocampal CA1, spatial novelty, novelty detection, synaptic plasticity, glutamatergic neurotransmission, memory formation
- MeSH terms
- Animals, Exploratory Behavior, Hippocampus, Male, Neurons, Receptors, Dopamine, Spatial Behavior, Rats, Wistar, Receptors, Dopamine D1, Long-Term Potentiation, Receptors, Dopamine D5, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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