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Mouse Model Resources for Vision Research

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Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Mollema, N., Yuan, Y., Jelcick, A. S., Sachs, A. J., von Alpen, D. C., Schorderet, D. F., Escher, P., & Haider, N. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017494 · Cited by 79 · see citing works

A Single Amino Acid Substitution (Cys249Trp) in Crb1 Causes Retinal Degeneration and Deregulates Expression of Pituitary Tumor Transforming GenePttg1

van de Pavert, S. A., Meuleman, J., Malysheva, A. N., Aartsen, W. M., Versteeg, I. A. J., Tonagel, F., Kamphuis, W., McCabe, C. J., Seeliger, M. W., & Wijnholds, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3496-06.2007 · Cited by 77 · see citing works

Mouse models of ocular diseases

Chang, B., Hawes, N. L., Hurd, R. E., Wang, J., Howell, D., Davisson, M. T., Roderick, T. H., Nusinowitz, S., & Heckenlively, J. R. (2005) · Visual Neuroscience · doi:10.1017/s0952523805225075 · Cited by 75 · see citing works

Genetic analysis of photoreceptor cell development in the zebrafish retina

Doerre, G., & Malicki, J. J. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00571-8 · Cited by 74 · see citing works

Effects of L1 retrotransposon insertion on transcript processing, localization and accumulation: lessons from the retinal degeneration 7 mouse and implications for the genomic ecology of L1 elements

Chen, J., Rattner, A., & Nathans, J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl138 · Cited by 73 · see citing works

Mutations in NR2E3 can cause dominant or recessive retinal degenerations in the same family

Escher, P., Gouras, P., Roduit, R., Tiab, L., Bolay, S., Delarive, T., Chen, S., Tsai, C., Hayashi, M., Zernant, J., et al. (2008) · Human Mutation · doi:10.1002/humu.20858 · Cited by 72 · see citing works

The Clinical Time-Course of Experimental Autoimmune Uveoretinitis Using Topical Endoscopic Fundal Imaging with Histologic and Cellular Infiltrate Correlation

Copland, D. A., Wertheim, M. S., Armitage, W. J., Nicholson, L. B., Raveney, B. J. E., & Dick, A. D. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2348 · Cited by 70 · see citing works

Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances

McClements, M. E., Staurenghi, F., MacLaren, R. E., & Cehajic‐Kapetanovic, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.570909 · Cited by 70 · see citing works

Cellular origin of fundus autofluorescence in patients and mice with a defective NR2E3 gene

Wang, N., Fine, H. F., Chang, S., Chou, C. L., Cella, W., Tosi, J., Lin, C.-S., Nagasaki, T., & Tsang, S. H. (2009) · British Journal of Ophthalmology · doi:10.1136/bjo.2008.153577 · Cited by 69 · see citing works

Retinoic Acid Regulates the Expression of Photoreceptor Transcription Factor NRL

Khanna, H., Akimoto, M., Siffroi‐Fernandez, S., Friedman, J. S., Hicks, D., & Swaroop, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605500200 · Cited by 69 · see citing works

Nr2e3 is a genetic modifier that rescues retinal degeneration and promotes homeostasis in multiple models of retinitis pigmentosa

Li, S., Datta, S., Brabbit, E., Love, Z., Woytowicz, V., Flattery, K., Capri, J., Yao, K., Wu, S., Imboden, M., et al. (2021) · Gene Therapy · doi:10.1038/s41434-020-0134-z · Cited by 68 · see citing works

The retinal mosaics of opsin expression in invertebrates and vertebrates

Rister, J., & Desplan, C. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20905 · Cited by 62 · see citing works

The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons

de Melo, J., Peng, G.-H., Chen, S., & Blackshaw, S. (2011) · Development · doi:10.1242/dev.061846 · Cited by 65 · see citing works

Animal modelling for inherited central vision loss

Kostic, C., & Arsenijévic, Y. (2015) · The Journal of Pathology · doi:10.1002/path.4641 · Cited by 64 · see citing works

Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice

Friedman, J. S., Chang, B., Krauth, D. S., López, I., Waseem, N. H., Hurd, R. E., Feathers, K. L., Branham, K. E. H., Shaw, M., Thomas, G. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002897107 · Cited by 63 · see citing works

Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.

Yanagi, Y., Takezawa, S., & Kato, S. (2002) · PubMed · Cited by 62 · see citing works

The role of opsin expression and apoptosis in determination of cone types in human retina

Cornish, E. E., Xiao, M., Yang, Z., Provis, J. M., & Hendrickson, A. E. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.01.004 · Cited by 62 · see citing works

Minireview: The Role of Nuclear Receptors in Photoreceptor Differentiation and Disease

Forrest, D., & Swaroop, A. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1010 · Cited by 60 · see citing works

Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity

Omori, Y., Kubo, S., Kon, T., Furuhashi, M., Narita, H., Kominami, T., Ueno, A. M., Tsutsumi, R., Chaya, T., Yamamoto, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707021114 · Cited by 60 · see citing works

Preventing exposure keratopathy in the critically ill: a prospective study comparing eye care regimes

Ezra, D. G. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2004.062406 · Cited by 60 · see citing works

Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors

Cheng, H., Khan, N. W., Roger, J. E., & Swaroop, A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr334 · Cited by 60 · see citing works

Preparation and square wave electroporation of retinal explant cultures

Donovan, S. L., & Dyer, M. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.454 · Cited by 58 · see citing works

Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells

Li, T., Lewallen, M. E., Chen, S., Yu, W., Zhang, N., & Xie, T. (2013) · Cell Research · doi:10.1038/cr.2013.48 · Cited by 56 · see citing works

Genetic modifiers of vision and hearing

Haider, N. B. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.10.1195 · Cited by 55 · see citing works

Preservation of Cone Photoreceptors after a Rapid yet Transient Degeneration and Remodeling in Cone-OnlyNrl−/−Mouse Retina

Roger, J. E., Ranganath, K., Zhao, L., Cojocaru, R. I., Brooks, M., Gotoh, N., Veleri, S., Hiriyanna, A., Rachel, R. A., Campos, M. M., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3591-11.2012 · Cited by 52 · see citing works

Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation

Onishi, A., Peng, G.-H., Chen, S., & Blackshaw, S. (2010) · Nature Neuroscience · doi:10.1038/nn.2618 · Cited by 52 · see citing works

Chromatin immunoprecipitation identifies photoreceptor transcription factor targets in mouse models of retinal degeneration: New findings and challenges

Peng, G.-H., & Chen, S. (2005) · Visual Neuroscience · doi:10.1017/s0952523805225063 · Cited by 52 · see citing works

Complete Transcriptome Profiling of Normal and Age-Related Macular Degeneration Eye Tissues Reveals Dysregulation of Anti-Sense Transcription

Kim, E. J., Grant, G. R., Bowman, A. S., Haider, N., Gudiseva, H. V., & Chavali, V. R. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21104-7 · Cited by 50 · see citing works

Dual role of Nr2e3 in photoreceptor development and maintenance

Webber, A. L., Hodor, P. G., Thut, C. J., Vogt, T., Zhang, T., Holder, D., & Petrukhin, K. E. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.04.006 · Cited by 49 · see citing works

Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing

Kumar, R. A., McGhee, K. A., Leach, S. R., Bonaguro, R. J., Maclean, A. W., Aguirre-Hernández, R., Abrahams, B. S., Coccaro, E. F., Hodgins, S., Turecki, G., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30696 · Cited by 48 · see citing works

Modifier genes as therapeutics: the nuclear hormone receptor Rev Erb alpha (Nr1d1) rescues Nr2e3 associated retinal disease

Cruz, N. M., Yuan, Y., Leehy, B. D., Baid, R., Kompella, U., DeAngelis, M. M., Escher, P., & Haider, N. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087942 · Cited by 47 · see citing works

Novel NR2E3 Mutations (R104Q, R334G) Associated with a Mild Form of Enhanced S-Cone Syndrome Demonstrate Compound Heterozygosity

Hayashi, T., Gekka, T., Goto‐Omoto, S., Takeuchi, T., Kubo, A., & Kitahara, K. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2005.07.002 · Cited by 47 · see citing works

The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation

Tan, M. H. E., Zhou, X. E., Soon, F.-F., Li, X., Li, J., Yong, E., Melcher, K., & Xu, H. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074359 · Cited by 46 · see citing works

Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor network

Peng, G.-H., & Chen, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109209108 · Cited by 43 · see citing works

The Determination of Rod and Cone Photoreceptor Fate

Cepko, C. L. (2015) · Annual Review of Vision Science · doi:10.1146/annurev-vision-090814-121657 · Cited by 46 · see citing works

Macular Function Assessed by Microperimetry in Patients with Enhanced S-Cone Syndrome

Sohn, E. H., Chen, F. K., Rubin, G. S., Moore, A. T., Webster, A. R., & MacLaren, R. E. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2009.10.046 · Cited by 45 · see citing works

The BALB/c mouse: Effect of standard vivarium lighting on retinal pathology during aging

Bell, B. A., Kaul, C. A., Bonilha, V. L., Rayborn, M. E., Shadrach, K. G., & Hollyfield, J. G. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.04.009 · Cited by 44 · see citing works

Fundus Autofluorescence Findings in a Mouse Model of Retinal Detachment

Secondi, R., Kong, J., Blonska, A. M., Staurenghi, G., & Sparrow, J. R. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9672 · Cited by 44 · see citing works

The C. elegans nuclear receptor gene fax-1 and homeobox gene unc-42 coordinate interneuron identity by regulating the expression of glutamate receptor subunits and other neuron-specific genes

Wightman, B., Ebert, B., Carmean, N., Weber, K. P., & Clever, S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.032 · Cited by 44 · see citing works

Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects

Hakkari, O. A.-H., Felder‐Schmittbuhl, M., Garrido, M. G., Beck, S. C., Seide, C., Sothilingam, V., Tanimoto, N., Seeliger, M. W., Bennis, M., & Hicks, D. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12103 · Cited by 41 · see citing works

Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse.

Rickman, C. B., Danciger, M., Kozak, C. A., & Farber, D. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9722 · Cited by 71 · see citing works

Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)

Travis, G. H., Brennan, M. B., Danielson, P. E., Kozak, C. A., & Sutcliffe, J. G. (1989) · Nature · doi:10.1038/338070a0 · Cited by 400 · see citing works

Two mouse retinal degenerations caused by missense mutations in the β-subunit of rod cGMP phosphodiesterase gene

Chang, B., Hawes, N. L., Pardue, M. T., German, A. M., Hurd, R. E., Davisson, M. T., Nusinowitz, S., Rengarajan, K., Boyd, A. P., Sidney, S. S., et al. (2007) · Vision Research · doi:10.1016/j.visres.2006.11.020 · Cited by 395 · see citing works

Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse.

Connell, G., Bascom, R. A., Molday, L. L., Reid, D. S., McInnes, R. R., & Molday, R. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.723 · Cited by 289 · see citing works

Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice

Haider, N. B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.16.1619 · Cited by 202 · see citing works