Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.
Open accessAbstract
Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.
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Coactivators are critical in mediating sexual differentiation of the brain.
“These results are also interesting when considered with findings suggesting that coactivators are critical in mediating sexual differentiation of the brain (14,17).”
From The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior (2010) · cites this paper as [17]
Masculinization of the male brain may in part be dependent on the effects of androgens on androgen receptors.
“masculinization of the male brain may in part be dependent on the effects of androgens on androgen receptors (Auger, Tetel, & McCarthy, 2000;Bakker, Honda, Harada, & Balthazart, 2002;Meaney & McEwen, 1986;Morris, Jordan, Dugger, & Breedlove, 2005).”
From Play fighting in androgen-insensitivetfm rats: Evidence that androgen receptors are necessary for the development of adult playful attack and defense (2006) · cites this paper as Auger, Tetel, & McCarthy, 2000
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SRC-1 Is Necessary for Skeletal Responses to Sex Hormones in Both Males and Females
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- Authors
- Auger, A. P., Tetel, M. J., & McCarthy, M. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-06-20
- Volume
- 97
- Issue
- 13
- Pages
- 7551-7555
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC16583
- OpenAlex
- W2035162632
- Cited by
- 196
- References
- 34
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 5
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH52716)
- National Institute of Mental Health (R29MH052716, MH 52716, R01MH052716)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD08618, F32HD008618)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- SRC-1, nuclear receptor coactivators, sexual differentiation of the brain, brain development, estrogen, defeminization, male reproductive behavior, steroid hormone action, neonatal rat brain
- MeSH terms
- Animals, Brain, Female, Male, Sexual Behavior, Animal, Transcription Factors, Trans-Activators, Rats, Sprague-Dawley, Gene Expression Regulation, Developmental, Rats, Histone Acetyltransferases, Nuclear Receptor Coactivator 1
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