The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP
Open accessAbstract
Interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of IFN-γ-regulated genes that encode 48-kDa GTP-binding proteins that localize to the endoplasmic reticulum. We have generated IGTP-deficient mice and found that, despite normal immune cell development and normal clearance of Listeria monocytogenes and cytomegalovirus infections, the mice displayed a profound loss of host resistance to acute infections of the protozoan parasite Toxoplasma gondii. By contrast, IFN-γ receptor-deficient mice have increased susceptibility to all three pathogens. Thus, IGTP defines an IFN-γ-regulated pathway with a specialized role in antimicrobial resistance.
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Research works printed but not linked: 1
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Cited by
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y.-J., Jiang, Q., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,304
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Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity
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Metadata
- Authors
- Taylor, G. A., Collazo, C. M., Yap, G. S., Nguyen, K., Gregorio, T. A., Taylor, L. S., Eagleson, B., Secrest, L., Southon, E. A., Reid, S. W., Tessarollo, L., Bray, M., McVicar, D. W., Komschlies, K. L., Young, H. A., Biron, C. A., Sher, A., & Vande Woude, G. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-01-18
- Volume
- 97
- Issue
- 2
- Pages
- 751-755
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2162641910
- Cited by
- 265
- References
- 27
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Taylor, G. A., Collazo, C. M., Yap, G. S., Nguyen, K., Gregorio, T. A., Taylor, L. S., Eagleson, B., Secrest, L., Southon, E. A., Reid, S. W., Tessarollo, L., Bray, M., McVicar, D. W., Komschlies, K. L., Young, H. A., Biron, C. A., Sher, A., & Vande Woude, G. F. (2000). Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.2.751
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