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Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

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CHASING THE CANCER DEMON

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DNA Damage Disrupts the p14ARF-B23(Nucleophosmin) Interaction and Triggers a Transient Subnuclear Redistribution of p14ARF

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Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesisPreprint

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p14 ARF Activates a Tip60-Dependent and p53-Independent ATM/ATR/CHK Pathway in Response to Genotoxic Stress

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Cellular Senescence in the Development and Treatment of Cancer

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A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization is Required for p53 Activation

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ATM mutations are associated with inactivation of theARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma

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Overexpression of c-Myc Alters G 1 /S Arrest following Ionizing Radiation

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DNA damage, p14ARF, Nucleophosmin (NPM/B23), and cancer

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ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc

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Association of p14ARF with the p120E4FTranscriptional Repressor Enhances Cell Cycle Inhibition

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Oncogenes and senescence: breaking down in the fast lanePreprint

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Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells

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Ellagic acid induces apoptosis in tsgh8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways

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Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression

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A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

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Ink4a / Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse

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p53-Induced Apoptosis Occurs in the Absence of p14ARF in Malignant Pleural Mesothelioma

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Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression

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ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

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The alternative reading frame tumor suppressor inhibits growth through p21-dependent and p21-independent pathways.

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p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts

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ARF mutation accelerates pituitary tumor development in Rb +/− mice

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A Defect in the p53 Response Pathway Induced by de Novo Purine Synthesis Inhibition

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A Novel Nuclear Interactor of ARF and MDM2 (NIAM) That Maintains Chromosomal Stability

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ATM activity contributes to the tumor-suppressing functions of p14ARF

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RRR-α-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest

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High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6

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The p53-Mdm2 Loop: A Critical Juncture of Stress Response

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Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2

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Zinc enhances CDKN2A , pRb1 expression and regulates functional apoptosis via upregulation of p53 and p21 expression in human breast cancer MCF-7 cell

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Immortalization of Human Mammary Epithelial Cells Is Associated with Inactivation of the p14ARF-p53 Pathway

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Deregulation of the Cell Cycle by the Epstein–Barr Virus

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Integration of the PRB and P53 Cell Cycle Control Pathways

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Human p14Arf: an exquisite sensor of morphological changes and of short-lived perturbations in cell cycle and in nucleolar function

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Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability

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Mdm2 Regulates p53 Independently of p19ARF in Homeostatic Tissues

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Regulation of p53 after Different Forms of Stress and at Different Cell Cycle StagesPreprint

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Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities

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NMI mediates transcription-independent ARF regulation in response to cellular stresses

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A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression

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Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53

Subash‐Babu, P., Alshammari, G. M., Savarimuthu Ignacimuthu, S. J., & Alshatwi, A. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.091 · Cited by 22

p14ARF expression in invasive breast cancers and ductal carcinoma in situ– relationships to p53 and Hdm2

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Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death

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Growth suppression by a p14ARF exon 1β adenovirus in human tumor cell lines of varying p53 and Rb status

Saadatmandi, N., Tyler, T., Huang, Y., Haghighi, A. P., Frost, G., Borgström, P., & Gjerset, R. A. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700505 · Cited by 20

Regulation of p53-dependent transcription

Jõers, A. (2004) · DSpace repository (University of Tartu) · Cited by 20

p19Arf is required for the cellular response to chronic DNA damage

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INK4a/ARF limits the expansion of cells suffering from replication stress

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E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway

Russell, J., Weaks, R. L., Berton, T. R., & Johnson, D. G. (2005) · Oncogene · doi:10.1038/sj.onc.1209120 · Cited by 17

The INK4a/ARF Locus and Human Cancer

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Final checkup of neoplastic DNA replication: Evidence for failure in decision-making at the mitotic cell cycle checkpoint G1/S

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Reversal of TNP-470-Induced Endothelial Cell Growth Arrest by Guanine and Guanine Nucleosides

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The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?

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Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX

Wahl, G. M., Stommel, J. M., Krummel, K. A., & Wade, M. R. (2005) · Springer eBooks · doi:10.1007/978-1-4020-2922-6_4 · Cited by 9

Modelling the p53 gene regulatory network.

Brewer, D. S. (2006) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 7

Nonpeptidomimetic Farnesyltransferase Inhibitor RPR-115135 Increases Cytotoxicity of 5-Fluorouracil: Role of p53

Russo, P., Ottoboni, C., Malacarne, D., Crippa, A., Riou, J., & O’Connor, P. M. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.1.220 · Cited by 6

The DNA Damage Response Mediates Apoptosis and Tumor Suppression

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Induction of micronuclei by a new non-peptidic mimetic farnesyltransferase inhibitor RPR-115135: role of gene mutations

Ottoboni, C. (2001) · Mutagenesis · doi:10.1093/mutage/16.5.423 · Cited by 5

Roles of ARF tumour suppressor protein in lung cancer: time to hit the nail on the head!

Vashi, R., & Patel, B. M. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03996-0 · Cited by 4

IRES-Mediated Protein Translation Overcomes Suppression by the p14ARF Tumor Suppressor Protein

Xi, S., Zhao, M., Wang, S., Ma, L., Wang, S., Cong, X., Gjerset, R. A., Fitzgerald, R. C., & Huang, Y. (2017) · Journal of Cancer · doi:10.7150/jca.17457 · Cited by 3

Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells

Treanor (2010) · International Journal of Oncology · doi:10.3892/ijo_00000650 · Cited by 3

The ARF protein in tumor suppression: lessons from mouse models and human tumors

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Microcephaly Gene Mcph1 Deficiency Induces p19ARF-Dependent Cell Cycle Arrest and Senescence

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