The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The major murine systemic lupus erythematosus susceptibility locus,Sle1, is a cluster of functionally related genes
Open accessAbstract
The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic to a chromosomal region linked with SLE susceptibility in multiple human studies. Congenic analyses have shown that Sle1 breaks tolerance to chromatin, a necessary step for full disease induction that can be suppressed by specific modifier loci. In the present study, our fine mapping analysis of the location of Sle1 has determined that three loci within this congenic interval, termed Sle1a,Sle1b, and Sle1c, can independently cause a loss of tolerance to chromatin. Each displays a distinctive profile of serological and cellular characteristics, with T and B cell functions being more affected by Sle1a and Sle1b, respectively. The epistatic interactions of Sle1 with other susceptibility loci to cause severe nephritis cannot be accounted, however, by these three loci alone, suggesting the existence of an additional locus, termed Sle1d. These findings indicate that the potent autoimmune phenotype caused by the Sle1 genomic interval reflects the combined impact of four, separate, susceptibility genes. This level of genetic complexity, combined with similar findings in other systems, supports the possibility that many complex trait loci reflect the impact of polymorphisms in linked clusters of genes with related functions.
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(2016) · Diagnostic Imaging: Brain · doi:10.1016/b978-0-323-37754-6.50094-4 · Cited by 3,990
A comprehensive genetic map of the mouse genome
Dietrich, W. F., Miller, J., Steen, R., Merchant, M. A., Damron-Boles, D., Husain, Z., Dredge, R., Daly, M. J., Ingalls, K. A., O'Connor, T. J., et al. (1996) · Nature · doi:10.1038/380149a0 · Cited by 827
Wu, J., Edberg, J. C., Redecha, P. B., Bansal, V, Guyre, P. M., Coleman, K., Salmon, J. E., & Kimberly, R. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119616 · Cited by 711
Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis
Clynes, R., Dumitru, C., & Ravetch, J. V. (1998) · Science · doi:10.1126/science.279.5353.1052 · Cited by 625
Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
Bickerstaff, M. C. M., Botto, M., Hutchinson, W. L., Herbert, J., Tennent, G. A., Bybee, A., Mitchell, D. A., Cook, H. T., Butler, P. J. G., Walport, M. J., et al. (1999) · Nature Medicine · doi:10.1038/9544 · Cited by 489
Polygenic control of susceptibility to murine systemic lupus erythematosus
Morel, L., Rudofsky, U. H., Longmate, J. A., Schiffenbauer, J., & Wakeland, E. K. (1994) · Immunity · doi:10.1016/1074-7613(94)90100-7 · Cited by 471
Self-citationFc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.
Salmon, J. E., Millard, S., Schachter, L. A., Arnett, F. C., Ginzler, E. M., Gourley, M. F., Ramsey-Goldman, R., Peterson, M. G., & Kimberly, R. P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118552 · Cited by 469
Mills, J. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406303302608 · Cited by 407
Morel, L., Croker, B. P., Blenman, K. R., Mohan, C., Huang, G., Gilkeson, G., & Wakeland, E. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6670 · Cited by 405
Self-citationLupus susceptibility loci in New Zealand mice.
Kono, D. H., Burlingame, R. W., Owens, D. G., Kuramochi, A., Balderas, R. S., Balomenos, D., & Theofilopoulos, A. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10168 · Cited by 344
Cited by
Rat genetics: attachign physiology and pharmacology to the genome
Jacob, H. J., & Kwitek, A. E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg702 · Cited by 274
Haugbro, K., Nossent, J. C., Winkler, T., Figenschau, Y., & Rekvig, O. P. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.016303 · Cited by 113
Kawasaki, K., Freimuth, J., Meyer, D. S., Lee, M. M., Tochimoto-Okamoto, A., Benzinou, M., Clermont, F. F., Wu, G., Roy, R., Letteboer, T. G. W., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318761111 · Cited by 47
Karlsson, J., Zhao, X., Lonskaya, I., Neptin, M., Holmdahl, R., & Andersson, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.1019 · Cited by 43
Lauwerys, B. R., & Wakeland, E. K. (2005) · Lupus · doi:10.1191/0961203305lu2052oa · Cited by 42
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Metadata
- Authors
- Morel, L., Blenman, K. R., Croker, B. P., & Wakeland, E. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-23
- Volume
- 98
- Issue
- 4
- Pages
- 1787-1792
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043263210
- Cited by
- 317
- References
- 26
- FWCI
- 19.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Morel, L., Blenman, K. R., Croker, B. P., & Wakeland, E. K. (2001). The major murine systemic lupus erythematosus susceptibility locus,Sle1, is a cluster of functionally related genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.4.1787
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