The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis
Abstract
The generation of autoantibody and subsequent tissue deposition of immune complexes (IC) is thought to trigger the pathogenic consequences of systemic autoimmune disease. Modulation of the autoantibody response disrupts pathogenesis by preventing the formation of ICs; however, uncoupling IC formation from subsequent inflammatory responses seems unlikely because of the apparent complexity of the IC-triggered inflammatory cascade. However, the disruption of a single gene, which encodes the γ chain of the Fc receptor, was found to achieve this uncoupling in a spontaneous model of lupus nephritis, the New Zealand Black/New Zealand White (NZB/NZW) mouse. Gamma chain–deficient NZB/NZW mice generated and deposited IC and activated complement, but were protected from severe nephritis, thus defining another potential pathway for therapeutic intervention in autoimmune disease.
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Wessels, M. R., Butko, P., Ma, M., Warren, H. B., Lage, A. L., & Carroll, M. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11490 · Cited by 503
Cited by
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Taming lupus-a new understanding of pathogenesis is leading to clinical advances
Liu, Z., & Davidson, A. (2012) · Nature Medicine · doi:10.1038/nm.2752 · Cited by 433
NF-κB in inflammation and renal diseases
Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383
Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
Suurmond, J., & Diamond, B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78084 · Cited by 337
Fc receptors are required in passive and active immunity to melanoma
Clynes, R., Takechi, Y., Moroi, Y., Houghton, A., & Ravetch, J. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.652 · Cited by 321
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Metadata
- Authors
- Clynes, R., Dumitru, C., & Ravetch, J. V.
- Venue
- Science
- Published
- 1998-02-13
- Volume
- 279
- Issue
- 5353
- Pages
- 1052-1054
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085406842
- Cited by
- 625
- References
- 1
- FWCI
- 32.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Clynes, R., Dumitru, C., & Ravetch, J. V. (1998). Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis. Science. https://doi.org/10.1126/science.279.5353.1052
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
