Cited by 561Physiological and biochemical adaptationsCancer, Hypoxia, and MetabolismPlant responses to water stress

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Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis

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Gracey, Andrew Y., Troll, Joshua V., Somero, George N.·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.98.4.1993PMC PMC29370

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Abstract

Hypoxia is important in both biomedical and environmental contexts and necessitates rapid adaptive changes in metabolic organization. Mammals, as air breathers, have a limited capacity to withstand sustained exposure to hypoxia. By contrast, some aquatic animals, such as certain fishes, are routinely exposed and resistant to severe environmental hypoxia. Understanding the changes in gene expression in fishes exposed to hypoxic stress could reveal novel mechanisms of tolerance that may shed new light on hypoxia and ischemia in higher vertebrates. Using cDNA microarrays, we have studied gene expression in a hypoxia-tolerant burrow-dwelling goby fish, Gillichthys mirabilis. We show that a coherent picture of a complex transcriptional response can be generated for a nonmodel organism for which sequence data were unavailable. We demonstrate that: ( i ) although certain shifts in gene expression mirror changes in mammals, novel genes are differentially expressed in fish; and ( ii ) tissue-specific patterns of expression reflect the different metabolic roles of tissues during hypoxia.

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Authors: Gracey, A. Y., Troll, J. V., & Somero, G. N.
Affiliations: Hopkins Marine Station (US)
ORCID: Gracey, Andrew Y.
Somero, George N.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-02-13
Volume: 98
Issue: 4
Pages: 1993-1998
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.98.4.1993
PMC: PMC29370
OpenAlex: W2008308093
Cited by: 561
References: 32
Citations by year: 2026: 7 · 2025: 7 · 2024: 15 · 2023: 9 · 2022: 10 · 2021: 21 · 2020: 13 · 2019: 18 · 2018: 20 · 2017: 31 · 2016: 21 · 2015: 19 · 2014: 19 · 2013: 23 · 2012: 21
FWCI: 27.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant responses to water stress
Keywords: hypoxia, hypoxia tolerance, Gillichthys mirabilis, gene expression profiling, transcriptional response, tissue-specific gene expression, hypoxia-ischemia
MeSH terms: Amino Acids, Animals, Hypoxia, Base Sequence, Brain, Cell Division, Glycolysis, Liver, Molecular Sequence Data, Myocardium, Oxygen, Perciformes, DNA, Complementary, Muscle, Skeletal, Gene Expression Profiling

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Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis

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