The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dual Oncostatin M (OSM) Receptors
Open accessAbstract
Oncostatin M (OSM) is a cytokine whose structural and functional features are similar to other members of the interleukin (IL)-6 family of cytokines (IL-6, IL-11, leukemia inhibitory factor (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and cardiotrophin-1), many of which utilize gp130 as a common receptor subunit. A biologically active OSM receptor has been previously described that consists of a heterodimer of leukemia inhibitory factor receptor (LIFR) and gp130. This LIFR.gp130 complex is also a functional receptor for LIF. We have cloned and characterized an alternative subunit (OSMRbeta) for an OSM receptor complex (a heterodimer of gp130 and OSMRbeta) that is activated by OSM but not by LIF. The signaling capability of specific receptor subunit combinations was analyzed by independent assays measuring cell proliferation or induction of acute phase protein synthesis. Our results demonstrate that both LIF and OSM cause tyrosine phosphorylation and activation of the gp130.LIFR combination, but the gp130.OSMRbeta complex is activated by OSM only. OSM-induced cellular responses, initiated through low affinity binding to gp130, are mediated by two heterodimeric receptor complexes that utilize alternative signal transducing subunits that confer different cytokine specificities to the receptor complex.
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Cites
Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components
Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., et al. (1994) · Science · doi:10.1126/science.8272873 · Cited by 979
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A new hepatocyte stimulating factor: cardiotrophin‐1 (CT‐1)
Peters, M., Roeb, E., Pennica, D., zum Büschenfelde, K.-H. M., & Rose-John, S. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00972-c · Cited by 39
Cited by
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Pleiotropy and specificity: insights from the interleukin 6 family of cytokines
Murakami, M., Kamimura, D., & Hirano, T. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.027 · Cited by 533
Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology
Hermanns, H. M. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.006 · Cited by 263
Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis
Mozaffarian, A., Brewer, A. W., Trueblood, E. S., Luzina, I. G., Todd, N. W., Atamas, S. P., & Arnett, H. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7243 · Cited by 153
Role of Oncostatin M in hematopoiesis and liver development
Miyajima, A., Kinoshita, T., Tanaka, M., Kamiya, A., Mukouyama, Y., & Hara, T. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00003-4 · Cited by 153
Essential Function of Oncostatin M in Nociceptive Neurons of Dorsal Root Ganglia
Morikawa, Y., Tamura, S., Minehata, K.-I., Donovan, P. J., Miyajima, A., & Senba, E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4975-03.2004 · Cited by 80
Hermanns, H. M., Radtke, S., Haan, C., Schmitz-Van de Leur, H., Tavernier, J., Heinrich, P. C., & Behrmann, I. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6651 · Cited by 71
Jenkins, B. J., Grail, D., Inglese, M., Quilici, C., Bozinovski, S., Wong, P., & Ernst, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1453-1463.2004 · Cited by 43
Metadata
- Authors
- Mosley, B., De Imus, C., Friend, D., Boiani, N., Thoma, B., Park, L. S., & Cosman, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 271
- Issue
- 51
- Pages
- 32635-32643
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2152295044
- Cited by
- 386
- References
- 3
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
