Cited by 395Metabolism, Diabetes, and CancerCancer, Lipids, and MetabolismPeroxisome Proliferator-Activated Receptors

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Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

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Vavvas, Demetrios, Apazidis, Alexios, Saha, Asish K., Gamble, James, Patel, Abhay, Kemp, Bruce E., Witters, Lee A., Ruderman, Neil B.·1997·Journal of Biological Chemistry

DOI 10.1074/jbc.272.20.13255

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Abstract

The concentration of malonyl-CoA, a negative regulator of fatty acid oxidation, diminishes acutely in contracting skeletal muscle. To determine how this occurs, the activity and properties of acetyl-CoA carboxylase beta (ACC-beta), the skeletal muscle isozyme that catalyzes malonyl-CoA formation, were examined in rat gastrocnemius-soleus muscles at rest and during contractions induced by electrical stimulation of the sciatic nerve. To avoid the problem of contamination of the muscle extract by mitochondrial carboxylases, an assay was developed in which ACC-beta was first purified by immunoprecipitation with a monoclonal antibody. ACC-beta was quantitatively recovered in the immunopellet and exhibited a high sensitivity to citrate (12-fold activation) and a Km for acetyl-CoA (120 microM) similar to that reported for ACC-beta purified by other means. After 5 min of contraction, ACC-beta activity was decreased by 90% despite an apparent increase in the cytosolic concentration of citrate, a positive regulator of ACC. SDS-polyacrylamide gel electrophoresis of both homogenates and immunopellets from these muscles showed a decrease in the electrophoretic mobility of ACC, suggesting that phosphorylation could account for the decrease in ACC activity. In keeping with this notion, citrate activation of ACC purified from contracting muscle was markedly depressed. In addition, homogenization of the muscles in a buffer free of phosphatase inhibitors and containing the phosphatase activators glutamate and MgCl2 or treatment of immunoprecipitated ACC-beta with purified protein phosphatase 2A abolished the decreases in both ACC-beta activity and electrophoretic mobility caused by contraction. The rapid decrease in ACC-beta activity after the onset of contractions (50% by 20 s) and its slow restoration to initial values during recovery (60-90 min) were paralleled temporally by reciprocal changes in the activity of the alpha2 but not the alpha1 isoform of 5'-AMP-activated protein kinase (AMPK). In conclusion, the results suggest that the decrease in ACC activity during muscle contraction is caused by an increase in its phosphorylation, most probably due, at least in part, to activation of the alpha2 isoform of AMPK. They also suggest a dual mechanism for ACC regulation in muscle in which inhibition by phosphorylation takes precedence over activation by citrate. These alterations in ACC and AMPK activity, by diminishing the concentration of malonyl-CoA, could be responsible for the increase in fatty acid oxidation observed in skeletal muscle during exercise.

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Authors: Vavvas, D., Apazidis, A., Saha, A. K., Gamble, J., Patel, A., Kemp, B. E., Witters, L. A., & Ruderman, N. B.
Affiliations: Boston University (US)
Dartmouth College (US)
St Vincents Institute of Medical Research (AU)
Corresponding author: Ruderman, Neil B.
ORCID: Vavvas, Demetrios
Apazidis, Alexios
Saha, Asish K.
Kemp, Bruce E.
Ruderman, Neil B.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1997-05
Volume: 272
Issue: 20
Pages: 13255-13261
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.272.20.13255
OpenAlex: W1964606633
Cited by: 395
References: 56
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 15 · 2017: 7 · 2016: 12 · 2015: 12 · 2014: 9 · 2013: 15 · 2012: 9
FWCI: 5.93
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8552 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Harvard University
Hebrew University of Jerusalem
National Institutes of Health (5r01dk019514-35)
Medical Research Council
National Health and Medical Research Council
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007201, DK-19514, DK-49417, T32-DK07201)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: ACACB, AMPK, skeletal muscle contraction, malonyl-CoA, citrate activation, protein phosphorylation, protein phosphatase 2A, gastrocnemius-soleus muscle, electrical stimulation, enzyme purification, immunoprecipitation
MeSH terms: Acetyl-CoA Carboxylase, Animals, Male, Multienzyme Complexes, Muscle Contraction, Protein Kinases, Rats, Sprague-Dawley, Protein Serine-Threonine Kinases, Muscle, Skeletal, Rats, AMP-Activated Protein Kinases

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Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

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