The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Hepatic Lipase Deficiency Increases Plasma Cholesterol but Reduces Susceptibility to Atherosclerosis in Apolipoprotein E-deficient Mice
Open accessAbstract
The effect of hepatic lipase (HL) deficiency on the susceptibility to atherosclerosis was tested using mice with combined deficiencies in HL and apoE. Mice lacking both HL and apoE (hhee) have a plasma total cholesterol of 917 +/- 252 mg/dl (n = 24), which is 184% that of mice lacking only apoE (HHee; 497 +/- 161 mg/dl, n = 20, p < 0. 001). The increase in cholesterol was mainly in beta-migrating very low density lipoproteins, although high density lipoprotein cholesterol (HDLc) was also increased (53 +/- 37 versus 20 +/- 13 mg/dl, p < 0.01). Despite the increase in plasma cholesterol, we found that HL deficiency significantly decreased aortic plaque sizes in female mice fed normal chow (31 x 10(3) +/- 22 x 10(3) microm2 in hhee versus 115 x 10(3) +/- 69 x 10(3) microm2 in HHee, p < 0.001). Reduction of plaque sizes was also observed in female heterozygous apoE-deficient mice fed an atherogenic diet (2 x 10(3) +/- 2.5 x 10(3) microm2 in hhEe versus 56 x 10(3) +/- 49 x 10(3) microm2 in HHEe, p < 0.01). Changes in aortic lesion size were not apparent in the small number of male mice studied. In HHee females, both HDLc and the capacity of high density lipoprotein (HDL) particles to promote cholesterol efflux from cultured cells were 26% of the wild type. The absence of HL in hhee females partially restored HDLc levels to 57% and cholesterol efflux to 55% of the wild type. Circulating pre-beta1-migrating HDL were present in all mutants, suggesting that there are alternative pathways in the formation of these pre-beta-HDL not involving apoE, HL, or cholesteryl ester transfer protein. The improved capacity to promote cholesterol efflux, together with increased HDL, may explain why these animals can overcome the increase in atherogenic lipoproteins.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We observed a large increase in small HDL species in our patient’s plasma, particularly prebeta-1 HDL, analogous to observations with ApoE knockout mice.33”
From Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function (2014) · cites this paper as [33]
Citations
Cites
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
Self-citationIdentification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,026
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944
Self-citationEarly incorporation of cell-derived cholesterol into pre-.beta.-migrating high-density lipoprotein
Castro, G. R., & Fielding, C. J. (1988) · Biochemistry · doi:10.1021/bi00401a005 · Cited by 641
Self-citationAtherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
Reddick, R. L., Zhang, S. H., & Maeda, N. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.141 · Cited by 633
Self-citationApolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.
Pászty, C., Maeda, N., Verstuyft, J. G., & Rubin, E. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117412 · Cited by 375
Self-citationGoldberg, I. J., Le, N., Paterniti, J. R., Ginsberg, H. N., Lindgren, F. T., & Brown, W. V. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110717 · Cited by 261
Protection Against Atherogenesis in Mice Mediated by Human Apolipoprotein A-IV
Duverger, N., Tremp, G. L., Caillaud, J., Emmanuel, F., Castro, G. R., Fruchart, J., Steinmetz, A., & Denèfle, P. (1996) · Science · doi:10.1126/science.273.5277.966 · Cited by 247
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–112 of 112
Atherosclerosis: cell biology and lipoproteins
Williams, K. J., & Rodrigueza, W. V. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199810000-00018 · Cited by 2
Genetics and molecular biology
Chamberlain, J. (1996) · Current Opinion in Lipidology · doi:10.1097/00041433-199612000-00013 · Cited by 1
Bamji‐Mirza, M. (2011) · Library and Archives Canada (Government of Canada) · doi:10.20381/ruor-4710
Use of Gene Transfer to Study HDL Remodeling
Oka, K., & Chan, L. (2007) · Wiley eBooks · doi:10.1002/9783527625178.ch9
Gomikawa, S., Suzuki, K., & Takamitu, Y. (1999) · American Journal of Nephrology · doi:10.1159/000013545
Bourg, A. L. (2006) · eCommons (Cornell University)
Les animaux génétiquement modifiés
Baroukh, N., Vergnes, L., Ostos, M. A., Zakin, M. M., & Ochoa, A. (2000) · Annales de l Institut Pasteur / Actualités · doi:10.1016/s0924-4204(00)80017-7
Transcriptional regulation of endothelial lipase and the role of VEGF-A in lipid metabolism
Kivelä, A. M. (2014) · UEF eRepo (University of Eastern Finland)
Genetics and molecular biology
Chamberlain, J. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199802000-00011
Alalawi, S., Rifqi, D., Alhamadi, A., Alotibi, R., Alradi, F., Alshehri, N., Chan, Y., Chen, J., Albalawi, F., Taha, S., et al. (2026) · Antioxidants · doi:10.3390/antiox15040507
The Functional and Structural Analysis of a Mimetic Peptide of Human Hepatic Lipase
Coady, B. M., Courage, E. R., Fitzpatrick, M. N., Hickey, K. E., Booth, V. K., & Brown, R. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.890.16
Metadata
- Authors
- Mezdour, H., Jones, R., Dengremont, C., Castro, G., & Maeda, N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Institut Pasteur (FR)
- Corresponding author
- Maeda, Nobuyo
- ORCID
- Maeda, Nobuyo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 272
- Issue
- 21
- Pages
- 13570-13575
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2071388690
- Cited by
- 113
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 42630)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein E deficiency, atherosclerosis susceptibility, serum cholesterol, HDL cholesterol, cholesterol efflux, aortic plaque, VLDL, prebeta-HDL, atherogenic diet, sex differences, cholesteryl ester transfer protein, lipoprotein metabolism, atheroprotection
- MeSH terms
- Animals, Apolipoproteins E, Arteries, Arteriosclerosis, Cholesterol, Electrophoresis, Agar Gel, Female, Lipase, Lipids, Lipoproteins, Lipoproteins, HDL, Liver, Male, Mice, Mutant Strains, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
