The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The Molecular Genetics of Rodent Single Gene Obesities
Open accessAbstract
Only three fundamental mechanisms can underlie the development of obesity: 1) relative increase in energy intake; 2) relative decrease in energy expenditure; and 3) preferential partitioning of ingested calories to fat storage. That any one of these defects is sufficient to cause obesity is demonstrated by the phenotypes of animals produced by specific transgenic manipulations as follows. 1) Disruption of the 5HT2c serotonin receptor results in hyperphagia and obesity (1). 2) Defective nonshivering thermogenesis (energy expenditure) is the major abnormality in obese mice with ablation of brown adipose tissue due to tissue-specific expression of the diphtheria toxin gene driven by the uncoupling protein promoter (2).
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Cites
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Cited by
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Self-citationActivation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
Zhang, Y., Lee, F. Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506982103 · Cited by 953
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Ozcan, L., Ergin, A. S., Lu, A., Chung, J., Sarkar, S., Nie, D., Myers, M. G., & Ozcan, U. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.004 · Cited by 875
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Activation of Downstream Signals by the Long Form of the Leptin Receptor
Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797
Metadata
- Authors
- Leibel, R. L., Chung, W. K., & Chua, S. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 272
- Issue
- 51
- Pages
- 31937-31940
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2016979581
- Cited by
- 286
- References
- 16
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Leibel, R. L., Chung, W. K., & Chua, S. C. (1997). The Molecular Genetics of Rodent Single Gene Obesities. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.51.31937
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
