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Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1
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Anterograde movement of lysosomes is regulated by BORC, Arl8, and SKIP, which links lysosomes to kinesin.
“Anterograde movement of lysosomes is regulated by the multi-subunit complex BORC, the small GTPase Arl8, and its effector SKIP, which directly interacts with the kinesin light chain, thus linking lysosomes to the plus-end-directed microtubule motor kinesin19,20.”
From TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes (2017) · cites this paper as [19]
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Metadata
- Authors
- Rosa-Ferreira, C., & Munro, S.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 21
- Issue
- 6
- Pages
- 1171-1178
- ISSN
- 1534-5807
- PMC
- PMC3240744
- Cited by
- 360
- References
- 4
- Language
- en
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