The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells
Open accessAbstract
Osteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF) is a recently identified cytokine that belongs to the tumor necrosis factor receptor superfamily and regulates bone mass by inhibiting osteoclastic bone resorption. The present study was undertaken to determine whether OPG/OCIF is produced in bone microenvironment and how the expression is regulated. A transcript for OPG/OCIF at 3.1 kilobases was detected in bone marrow stromal cells (ST2 and MC3T3-G2/PA6) as well as in osteoblastic cells (MC3T3-E1). Transforming growth factor-beta1 (TGF-beta1) markedly increased the steady-state level of OPG/OCIF mRNA in a dose-dependent manner, while TGF-beta1 suppressed the mRNA expression of tumor necrosis factor-related activation-induced cytokine (TRANCE)/receptor activator of NF-kappaB ligand (RANKL), a positive regulator of osteoclastogenesis to which OPG/OCIF binds. The effect of TGF-beta1 on the expression of OPG/OCIF mRNA was transient, with a peak level at 3-6 h. The up-regulation of OPG/OCIF mRNA by TGF-beta1 in ST2 cells did not require de novo protein synthesis and involved both a transcriptional and a post-transcriptional mechanism. Western blot analysis and an enzyme-linked immunosorbent assay revealed that TGF-beta1 significantly increased the secretion of OPG/OCIF protein by ST2 cells at 6-24 h. In murine bone marrow cultures, TGF-beta1 markedly inhibited the formation of tartrate-resistant acid phosphatase-positive multinucleated osteoclast-like cells in the presence of 1,25-dihydroxyvitamin D3, whose effect was significantly reversed by a neutralizing antibody against OPG/OCIF. These results suggest that TGF-beta1 negatively regulates osteoclastogenesis, at least in part, through the induction of OPG/OCIF by bone marrow stromal cells and that the balance between OPG/OCIF and TRANCE/RANKL in local environment may be an important determinant of osteoclastic bone resorption.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“High TGF-β1 expression inhibits the migration of osteoclast precursors208 by suppressing RANKL expression and by stimulating OPG production in osteoblasts.209”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [209]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
Self-citationA homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Sudo, H., Kodama, H. A., Amagai, Y., Yamamoto, S., & Kasai, S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.191 · Cited by 1,673
Manolagas, S. C., & Jilka, R. L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320506 · Cited by 1,670
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,264
Research works printed but not linked: 3
- Roodman, 1996, Endocr. Rev., 17, 308
- Chomczynski, 1987, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2 · DOI
- Centrella, 1994, Endocr. Rev., 15, 27
Cited by
Sorted by citations
Items 201–299 of 299
Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy
Gradošová, I., Živná, H., Palička, V., Hubená, S., Švejkovská, K., & Živný, P. (2012) · Pharmacology · doi:10.1159/000335491 · Cited by 17
Masuda, K., Ikeuchi, M., Koyama, T., Yamaguchi, K., Woo, J.-T., Nishimura, T., & Yazawa, K. (2008) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0810-8 · Cited by 18
Osteoclast: Origin and Differentiation
Rubin, J. E., & Greenfield, E. M. (2005) · Springer eBooks · doi:10.1007/1-84628-016-8_1 · Cited by 18
Sánchez‐de‐Diego, C., Yada, R. C., Sethakorn, N., Geiger, P. G., Ding, A. B., Héninger, E., Ahmed, F., Virumbrales-Muñoz, M., Lupsa, N., Bartels, E., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08384-2 · Cited by 18
Chung, E., & Rylander, M. N. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0414 · Cited by 16
Pathogenesis of Myelofibrosis With Myeloid Metaplasia: Lessons From Mouse Models of the Disease
Vannucchi, A. M. (2005) · Seminars in Oncology · doi:10.1053/j.seminoncol.2005.04.008 · Cited by 16
Corticosteroid-Induced Osteoporosis
Clarke, B. L. (2012) · American Journal of Clinical Dermatology · doi:10.2165/11594250-000000000-00000 · Cited by 16
Tazoe, M., Mogi, M., Goto, S., & Togari, A. (2003) · Archives of Oral Biology · doi:10.1016/s0003-9969(03)00100-6 · Cited by 16
Janus kinase inhibitors role in bone remodeling
Maruotti, N., Corrado, A., Rotondo, C., & Cantatore, F. P. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29149 · Cited by 15
Pathogenesis of myelofibrosis with myeloid metaplasia: Insight from mouse models
Chagraoui, H., Wendling, F., & Vainchenker, W. (2006) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2005.07.002 · Cited by 15
蕨, 信., Tachibana, Y., Kumegawa, M., & Hakeda, Y. (2001) · Cytotechnology · doi:10.1023/a:1008159332152 · Cited by 14
The impact of forced swimming on expression of RANKL and OPG in a type 2 diabetes mellitus rat model
Pezhman, L., Hesari, F. S., Ghiasi, R., & Alipour, M. R. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1446178 · Cited by 15
Bennett, A. K., Hester, P. Y., & Spurlock, D. M. (2007) · Poultry Science · doi:10.1093/ps/86.5.829 · Cited by 13
Nakagawa, N., Yasuda, H., Yano, K., Mochizuki, S.-I., Kobayashi, N., Fujimoto, H., Yamaguchi, K., Shima, N., Morinaga, T., & Higashio, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1621 · Cited by 13
Self-citationChiba-Ohkuma, R., Karakida, T., Yamamoto, R., & Yamakoshi, Y. (2025) · JBMR Plus · doi:10.1093/jbmrpl/ziaf104 · Cited by 12
The early phase response of rat alveolar bone to traumatic occlusion
Wan, H., Sun, H. Q., Sun, G.-X., Li, X., & Shang, Z. (2012) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2012.01.002 · Cited by 12
Osteoprotegerin and Bone Mass in Squamous Cell Head and Neck Cancer Patients
Valero, C., Olmos, J. M., Rivera, F., Hernández, J. L., Vega, M. E., & Macías, J. G. (2006) · Calcified Tissue International · doi:10.1007/s00223-005-0237-y · Cited by 12
Yang, X., Halladay, D., Onyia, J. E., Martin, T. J., & Chandrasekhar, S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6176 · Cited by 12
Inoue, M., Nagai‐Yoshioka, Y., Yamasaki, R., Kawamoto, T., Nishihara, T., & Ariyoshi, W. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262612 · Cited by 11
Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., PARFITT, A. M., & Manolagas, S. C. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50112-8 · Cited by 21
Rostami, G., Siddappa, R. H. R., & Kishen, A. (2025) · Journal of Endodontics · doi:10.1016/j.joen.2025.08.018 · Cited by 12
Rzepka, R., Dołęgowska, B., Sałata, D., Rajewska, A., Budkowska, M., Domański, L., Kwiatkowski, S., Mikołajek-Bedner, W., & Torbè, A. (2015) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-015-0559-3 · Cited by 10
TGF-β in jaw tumor fluids induces RANKL expression in stromal fibroblasts
Yamada, C., Aikawa, T., Okuno, E., Miyagawa, K., Amano, K., Takahata, S., Kimata, M., Okura, M., Iida, S., & Kogo, M. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3548 · Cited by 10
Zhang, N., Wu, X., Wu, X., Fu, X., Du, X.-Y., Xie, H., Peng, Y., Luo, X., & Liao, E.-Y. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.01.021 · Cited by 10
Pacifici, R. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50042-8 · Cited by 10
Rickard, D. G., Harris, S. A., TURNER, R., Khosla, S., & Spelsberg, T. C. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50139-6 · Cited by 10
Osteoprotegerin expression and serum values in obese women with type 2 diabetes mellitus
Rashad, N. M., El‐Shal, A. S., Shalaby, S. M., Abdelnour, H. M., & Sarhan, W. M. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06699-x · Cited by 9
PDGF BB purified from osteoclasts acts as osteoblastogenesis inhibitory factor (OBIF).
Kubota, K., Sakikawa, C., Katsumata, M., Nakamura, T., & Wakabayashi, K. (2002) · PubMed Central · Cited by 9
Sung, E., Kwon, O. K., Lee, J., & Lee, S. (2017) · Electrophoresis · doi:10.1002/elps.201700052 · Cited by 9
Mechanisms of Estrogen Action in Bone
Pacifici, R. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00059-8 · Cited by 9
Association of SMAD2 polymorphisms with bone mineral density in postmenopausal Korean women
Kim, B., Hwang, J. Y., Han, B. G., Lee, J., Lee, J., Park, E. K., Lee, S. H., Chung, Y. E., Kim, G. S., Kim, S.-Y., et al. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1450-8 · Cited by 8
Anabolic effects of a G protein–coupled receptor kinase inhibitor expressed in osteoblasts
Spurney, R. F., Flannery, P. J., Garner, S. C., Athirakul, K., Liu, S., Guilak, F., & Quarles, L. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200214663 · Cited by 8
TGF-β and Physiological Root Resorption of Deciduous Teeth
Shimazaki, E., Karakida, T., Yamamoto, R., Kobayashi, S., Fukae, M., Yamakoshi, Y., & Asada, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010049 · Cited by 8
Mundy, G. R., Oyajobi, B. O., Traianedes, K., Dallas, S. L., & Chen, D. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50014-3 · Cited by 8
Osteoprotegerin: regulator, protector and marker
Othmane, T., Speer, G., Fekete, B., Szabó, T., Egresits, J., Fodor, E., Kiss, I., Nemcsik, J., Szabó, A., Németh, Z., et al. (2008) · Orvosi Hetilap · doi:10.1556/oh.2008.28470 · Cited by 7
Chaiya, I., & Rattanakul, C. (2017) · Advances in Difference Equations · doi:10.1186/s13662-017-1206-2 · Cited by 7
NF-κB Decoy ODN-Loaded Poly(Lactic-co-glycolic Acid) Nanospheres Inhibit Alveolar Ridge Resorption
Huang, A. C.-S., Ishida, Y., Li, K., Rintanalert, D., Hatano-sato, K., Oishi, S., Hosomichi, J., Usumi‐Fujita, R., Yamaguchi, H., Tsujimoto, H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043699 · Cited by 6
Prohibitins, novel vitamin K2 target factors in osteoblast
Uebi, T., Umeda, M., Maekawa, N., Karasawa, S., Handa, H., & Imai, T. (2013) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2013.13001 · Cited by 6
Wada, Y., Mizuno, M., & Tamura, M. (2009) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.01.004 · Cited by 6
Ascone, G., Ceglie, I. D., Walgreen, B., Sloetjes, A. W., Lindhout, E., Bot, I., van de Loo, F. A. J., Koenders, M. I., van der Kraan, P. M., Blom, A. B., et al. (2019) · Bone · doi:10.1016/j.bone.2019.115140 · Cited by 6
Al-Nasrallah, H. K., Al‐Ansari, M. M., & Aboussekhra, A. (2022) · Cells · doi:10.3390/cells11213369 · Cited by 4
The Role of the Immune System in the Development of Osteoporosis
Mödder, U. I., Riggs, B. L., & Khosla, S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375670-1.10009-3 · Cited by 4
Skeletal Fragility in the Elderly
Inzerillo, A. M., Iqbal, J. Z., Troen, B. R., Meier, D. E., & Zaidi, M. (2006) · Springer eBooks · doi:10.1007/0-387-22621-4_44 · Cited by 4
The Effects of Adiponectin on Bone Metabolism
Lin, Y., Chen, C., Chen, C. C., Lin, H. J., Mersmann, H. J., Wu, S., & Ding, S. (2014) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2014.79062 · Cited by 3
Futakuchi, M., Nitanda, T., Ando, S., Matsumoto, H., Yoshimoto, E., Fukamachi, K., & Suzui, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030888 · Cited by 3
Wan, C., Wang, Y., Li, L., Liu, L., & Guan, Q. (2023) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2023.105796 · Cited by 3
How to get to the right place at the right time: Rab/Ypt small GTPases and vesicle transport
Ragnini‐Wilson, A. (1999) · PROTOPLASMA · doi:10.1007/bf01415697 · Cited by 3
Sakakura, Y. (2010) · Journal of Oral Biosciences · doi:10.1016/s1349-0079(10)80043-x · Cited by 3
Liu, Y., Habibie, H., Borghuis, T., Liu, G., Hansbro, P. M., Melgert, B. N., & Burgess, J. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.05.626371 · Cited by 3
Tae, H. J., Baek, K., Oh, E.-S., Oh, K. W., Lee, W., Kim, H.-S., Han, J.-H., Cha, B. Y., Lee, K. W., Son, H., et al. (2005) · Journal of Korean Endocrine Society · doi:10.3803/jkes.2005.20.1.40 · Cited by 1
Skeletal Health in Pediatric Inflammatory Bowel Disease
Sylvester, F. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-73481-1_11 · Cited by 2
The Role of Sex Steroids in the Effects of Immune System on Bone
Grčević, D., Kovačić, N., & Lee, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00012-8 · Cited by 2
Levels of TGF-β1 in peri-miniscrew implant crevicular fluid
Kaur, A., Kharbanda, O. P., Rajeswari, M. R., & Kalyanasundaram, D. (2020) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2020.03.002 · Cited by 2
Influence of osteoprotegerin (OPG) on experimentally induced ectopic bone
Włodarski, K. H., Kochanowska, I. E., Pieńkowski, M., & Ostrowski, K. (2004) · Folia Biologica · doi:10.3409/1734916044527520 · Cited by 2
Osteoclastogénesis y enfermedades óseas
Mikán, V. J. F., & Oliveros, A. W. D. (2007) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 2
Hofstetter, W., & Gillespie, M. T. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50154-2 · Cited by 3
The Molecular Pharmacology of Osteoporosis
Iqbal, J. Z., Inzerillo, A. M., Moonga, B. S., & Zaidi, M. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-278-4_28 · Cited by 2
Regulation of RANKL-Induced Osteoclastogenesis by TGF-β
Yasui, T., Yasuda, H., & Tanaka, S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5366-6_11 · Cited by 1
The Current Knowledge of Genetic Susceptibility Influencing Dental Implant Outcomes
Alvim‐Pereira, F., Cristina, C., & Cristina, P. (2011) · InTech eBooks · doi:10.5772/18065 · Cited by 1
Influence of Osteoprotegerin (OPG) on Resorption of Heterotopically Induced Ossicle
Kochanowska, I. E., Włodarski, K., Pienkowski, M. M., & Ostrowski, K. (2004) · Cell and Tissue Banking · doi:10.1023/b:catb.0000034095.83717.23 · Cited by 1
Mundy, G. R., Oyajobi, B. O., Gutierrez, G., Sterling, J. A. R., Padalecki, S. S., Elefteriou, F., & Zhao, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50019-6 · Cited by 1
Costa, V., Raimondi, L., Bellavia, D., Luca, A. D., Guglielmi, P., Cusanno, A., Cattini, L., Pulsatelli, L., Pavarini, M., Chiesa, R., et al. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16080303 · Cited by 1
Influence of the Bone Microenvironment on Breast Cancer Metastasis to Bone
Eckhardt, B. L., Pouliot, N., & Anderson, R. L. (2005) · Springer eBooks · doi:10.1007/1-4020-3414-8_8 · Cited by 1
KEITHJR, J. (2003) · Elsevier eBooks · doi:10.1016/b978-012689663-3/50019-3 · Cited by 1
Dendritic Cell-Associated Osteoclastogenesis and Bone Loss
Liu, Y.-C. G., & Teng, Y.-T. A. (2009) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-009-9059-1 · Cited by 1
Osteokonduktion und Hydroxylapatitkeramiken
Soldner, E. H., Herr, G., Schnettler, R., & Börner, M. (2001) · Trauma und Berufskrankheit · doi:10.1007/s10039-001-0502-x · Cited by 1
The Role of Purinergic Signaling in the Interactions between Skeletal Cells
Gartland, A., Gallagher, J. A., & Buckley, K. (2006) · CRC Press eBooks · doi:10.1201/9780849333682.ch3 · Cited by 1
Bolon, B. N., Shalhoub, V., Kostenuik, P. J., Zack, D. J., & Feige, U. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7883-8_10
Bedeutung von RANK-Ligand und Osteoprotegerin für den Knochenstoffwechsel
Hofbauer, L. C., & Schoppet, M. (2006) · Springer eBooks · doi:10.1007/3-540-28782-5_21
An Agent-based Model for Evaluating Cellular Mechanisms of Bone Remodeling
Schutte, L. (2012) · KiltHub Repository · doi:10.1184/r1/6714668
Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models
Hollberg, K. (2007) · Figshare
Osteogenetic growth factors around loosened hip replacements
Waris, V. J. (2014) · Työväentutkimus Vuosikirja
Cytokine regulation of bone destruction
Lubberts, E., & van den Berg, W. B. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7883-8_11
Osteoprotegerin: a pathological role in human abdominal aortic aneurysm
Moran, C. S. (2025) · ResearchOnline at James Cook University (James Cook University) · doi:10.25903/j9h2-9r90
Novel roles of bone lining cells in bone remodeling
Pérez‐Amodio, S. (2005)
Mardock, M. A. (2003) · VTechWorks (Virginia Tech)
Acidosis, osteoclast formation and cathepsin K expression in the loosening of total hip prostheses
Mandelin, J. (2005) · Työväentutkimus Vuosikirja
Biomimetica per l'ingegneria tissutale dell'osso
Devescovi, V. (2008) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/705
Inflammatory Bowel Diseases and Skeletal Health
Sylvester, F. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5061-0_13
Mecanismos de calcificación vascular asociados a la uremia y al tratamiento con Calcitriol.
García, S. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Rola RANK/RANKL i OPG w szpiczaku plazmocytowym* The role of RANK/RANKL and OPG in multiple myeloma
Kandefer‐Szerszeń, M. (2006)
Furuta, T. (2000) · Japanese Journal of Oral Biology · doi:10.2330/joralbiosci1965.42.121
New Approaches to Osteoporosis Therapeutics
Stoch, S. A., Chorev, M., & Rosenblatt, M. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50080-5
Studies of Interactions Between Myeloma Cells and Osteoblasts: In Vitro
Karadağ, A. (2019) · OpenGrey (Institut de l'Information Scientifique et Technique)
Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
Chung, E. (2010) · VTechWorks (Virginia Tech)
Crawford, M. R., Williams, S. E., Khan, L. Z., & Licata, A. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-03694-2_15
New Approaches to Osteoporosis Therapeutics
Dresner–Pollak, R., Stoch, S. A., & Rosenblatt, M. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50082-3
Mechanisms of Estrogen Action in Bone
Pacifici, R. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50141-4
Review The role of the bone marrow microenvironment in multiple myeloma
Vanderkerken, K. (2005)
Abdulkhaliq, A. A. (2021) · Springer eBooks · doi:10.1007/978-981-15-8323-0_10
Transforming growth factor-β and its signaling pathway in skeletal complications of malignancy
Juárez, P., Iduarte, B. I., & Fournier, P. G. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821666-8.00071-2
Chambers, T. J. (2003) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-55742-2_19
The Role of Purinergic Signaling in the Interactions between Skeletal Cells
Gartland, A., Gallagher, J. A., & Buckley, K. (2006) · CRC Press eBooks · doi:10.1201/9781420005059.ch3
Ye, J., Hua, Z., Xiao, J., Shao, Y., Li, S., Yin, H., Wu, M., Rong, Y., Hong, B., Guo, Y., et al. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09400-0
Role of Transforming Growth Factor Beta 1 in Reducing Orthodontic Relapse: Rabbit Model Study
Zubaidi, S. H. A., Alsaleem, N. R., & AlKataan, M. A. A. (2024) · Asian Journal of Dairy and Food Research · doi:10.18805/ajdfr.drf-401
Kim, J.-E., Go, J., Lee, E.-J., Kim, S.-M., Jung, D., No, H., Hyun, M., Lee, Y.-J., Sung, Y., Ju, M. K., et al. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-026-00994-w
Ceylan, M., de Vries, T. J., Runderkamp, W. J. A. M., Jansen, I. D. C., Schimmel, I. M., Picavet, D. I., Laine, M. L., & Schoenmaker, T. (2026) · Bone Reports · doi:10.1016/j.bonr.2026.101940
Metadata
- Authors
- Takai, H., Kanematsu, M., Yano, K., Tsuda, E., Higashio, K., Ikeda, K., Watanabe, K., & Yamada, Y.
- Affiliations
- Megmilk Snow Brand (Japan) (JP)
- Corresponding author
- Yamada, Yoshiji
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 273
- Issue
- 42
- Pages
- 27091-27096
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1994756823
- Cited by
- 299
- References
- 38
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- osteoprotegerin, TGF-β1, mesenchymal stem cells, RANKL, osteoclastogenesis, bone resorption, osteoblasts, transcriptional regulation, post-transcriptional regulation, osteoclast-like cells, 1,25-dihydroxyvitamin D3
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Cell Line, Dose-Response Relationship, Drug, Gene Expression Regulation, Glycoproteins, Models, Biological, Osteoclasts, RNA, Messenger, Transforming Growth Factor beta, Stromal Cells, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Mice, Osteoprotegerin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review