The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells
Open accessAbstract
Osteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF) is a recently identified cytokine that belongs to the tumor necrosis factor receptor superfamily and regulates bone mass by inhibiting osteoclastic bone resorption. The present study was undertaken to determine whether OPG/OCIF is produced in bone microenvironment and how the expression is regulated. A transcript for OPG/OCIF at 3.1 kilobases was detected in bone marrow stromal cells (ST2 and MC3T3-G2/PA6) as well as in osteoblastic cells (MC3T3-E1). Transforming growth factor-beta1 (TGF-beta1) markedly increased the steady-state level of OPG/OCIF mRNA in a dose-dependent manner, while TGF-beta1 suppressed the mRNA expression of tumor necrosis factor-related activation-induced cytokine (TRANCE)/receptor activator of NF-kappaB ligand (RANKL), a positive regulator of osteoclastogenesis to which OPG/OCIF binds. The effect of TGF-beta1 on the expression of OPG/OCIF mRNA was transient, with a peak level at 3-6 h. The up-regulation of OPG/OCIF mRNA by TGF-beta1 in ST2 cells did not require de novo protein synthesis and involved both a transcriptional and a post-transcriptional mechanism. Western blot analysis and an enzyme-linked immunosorbent assay revealed that TGF-beta1 significantly increased the secretion of OPG/OCIF protein by ST2 cells at 6-24 h. In murine bone marrow cultures, TGF-beta1 markedly inhibited the formation of tartrate-resistant acid phosphatase-positive multinucleated osteoclast-like cells in the presence of 1,25-dihydroxyvitamin D3, whose effect was significantly reversed by a neutralizing antibody against OPG/OCIF. These results suggest that TGF-beta1 negatively regulates osteoclastogenesis, at least in part, through the induction of OPG/OCIF by bone marrow stromal cells and that the balance between OPG/OCIF and TRANCE/RANKL in local environment may be an important determinant of osteoclastic bone resorption.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“High TGF-β1 expression inhibits the migration of osteoclast precursors208 by suppressing RANKL expression and by stimulating OPG production in osteoblasts.209”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [209]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
Self-citationA homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Sudo, H., Kodama, H. A., Amagai, Y., Yamamoto, S., & Kasai, S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.191 · Cited by 1,673
Manolagas, S. C., & Jilka, R. L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320506 · Cited by 1,670
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,264
Research works printed but not linked: 3
- Roodman, 1996, Endocr. Rev., 17, 308
- Chomczynski, 1987, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2 · DOI
- Centrella, 1994, Endocr. Rev., 15, 27
Cited by
Sorted by citations
Minireview: The OPG/RANKL/RANK System
Khosla, S. (2001) · Endocrinology · doi:10.1210/endo.142.12.8536 · Cited by 1,515
RANK is essential for osteoclast and lymph node development.
Dougall, W. C., Glaccum, M., Charrier, K., Rohrbach, K., Brasel, K., De Smedt, T., Daro, E., Smith, J., Tometsko, M. E., Maliszewski, C. R., et al. (1999) · Genes & Development · doi:10.1101/gad.13.18.2412 · Cited by 1,478
Autologous platelets as a source of proteins for healing and tissue regeneration
Anitua, E., Andı́a, I., Ardanza, B., Nurden, P., & Nurden, A. T. (2003) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0440 · Cited by 1,496
Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Boyle, W. J., & Riggs, B. L. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.2 · Cited by 1,185
Changes in Proinflammatory Cytokine Activity after Menopause
Pfeilschifter, J., Köditz, R., Pfohl, M., & Schatz, H. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0456 · Cited by 929
Burger, J. A., Tsukada, N., Burger, M., Zvaifler, N. J., Dell’Aquila, M. L., & Kipps, T. J. (2000) · Blood · doi:10.1182/blood.v96.8.2655 · Cited by 752
Transforming Growth Factor-β1 to the Bone
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710
Hofbauer, L. C., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L., & Khosla, S. (1999) · Bone · doi:10.1016/s8756-3282(99)00162-3 · Cited by 630
Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology
Hofbauer, L. C., & Heufelder, A. E. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100226 · Cited by 586
Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation1
Thomas, R. J., Guise, T. A., Yin, J. J., Elliott, J., Horwood, N. J., Martin, T. J., & Gillespie, M. T. (1999) · Endocrinology · doi:10.1210/endo.140.10.7037 · Cited by 536
Alliston, T., Choy, L., Ducy, P., Karsenty, G., & Derynck, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2254 · Cited by 526
Pearse, R. N., Sordillo, E. M., Yaccoby, S., Wong, B. R., Liau, D. F., Colman, N., Michaeli, J., Epstein, J., & Choi, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201394498 · Cited by 518
Li, Y., Toraldo, G., Li, A., Yang, X., Zhang, H., Qian, W.-P., & Weitzmann, M. N. (2007) · Blood · doi:10.1182/blood-2006-07-037994 · Cited by 520
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
Takahashi, N., Udagawa, N., & Suda, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0252 · Cited by 461
Preshaw, P. M., & Taylor, J. J. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01671.x · Cited by 438
RANK/RANKL: Regulators of Immune Responses and Bone Physiology
Leibbrandt, A., & Penninger, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.016 · Cited by 420
Activated T Lymphocytes Support Osteoclast Formation in Vitro
Horwood, N. J., Kartsogiannis, V., Quinn, J. M. W., Romas, E., Martin, T. J., & Gillespie, M. T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1623 · Cited by 416
Bone regeneration and stem cells
Arvidson, K., Abdallah, B. M., Applegate, L. A., Baldini, N., Cenni, E., Gómez‐Barrena, E., Granchi, D., Kassem, M. S., Konttinen, Y. T., Mustafa, K. B. E., et al. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01224.x · Cited by 406
RANK Ligand and Osteoprotegerin
Schoppet, M., Preissner, K. T., & Hofbauer, L. C. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000012303.37971.da · Cited by 408
Udagawa, N., Takahashi, N., Yasuda, H., Mizuno, A., Itoh, K., Ueno, Y., Shinki, T., Gillespie, M. T., Martin, T. J., Higashio, K., et al. (2000) · Endocrinology · doi:10.1210/endo.141.9.7634 · Cited by 411
Self-citationRheumatic diseases: the effects of inflammation on bone
Walsh, N. C., Crotti, T. N., Goldring, S. R., & Gravallese, E. M. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00338.x · Cited by 385
Yano, K., Tsuda, E., Washida, N., Kobayashi, F., Goto, M., Harada, A., Ikeda, K., Higashio, K., & Yamada, Y. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.4.518 · Cited by 363
Self-citationThe role of the immune system in the pathophysiology of osteoporosis
Clowes, J. A., Riggs, B. L., & Khosla, S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00334.x · Cited by 366
Kaneko, H., Arakawa, T., Mano, H., Kaneda, T., Ogasawara, A., Nakagawa, M., Toyama, Y., Yabe, Y., Kumegawa, M., & Hakeda, Y. (2000) · Bone · doi:10.1016/s8756-3282(00)00358-6 · Cited by 347
MLO-Y4 Osteocyte-Like Cells Support Osteoclast Formation and Activation
Zhao, S., Kato, Y., Zhang, Y., Harris, S., Ahuja, S. S., & Bonewald, L. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.2068 · Cited by 322
Cytokine responses against periodontal infection: protective and destructive roles
Liu, Y.-C. G., Lerner, U. H., & Teng, Y.-T. A. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00321.x · Cited by 308
A novel molecular mechanism modulating osteoclast differentiation and function
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Goto, M., Mochizuki, S.-I., Tsuda, E., Morinaga, T., Udagawa, N., et al. (1999) · Bone · doi:10.1016/s8756-3282(99)00121-0 · Cited by 264
Self-citationWeitzmann, M. N. (2013) · Scientifica · doi:10.1155/2013/125705 · Cited by 264
The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
Zou, M., Chen, Z.-H., Teng, Y., Liu, S.-Y., Yuan, J., Zhang, K., Sun, Z., Wu, J., Yuan, Z., Feng, Y., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.593310 · Cited by 255
Transforming Growth Factor β Affects Osteoclast Differentiation via Direct and Indirect Actions
Quinn, J. M. W., Itoh, K., Udagawa, N., Häusler, K., Yasuda, H., Shima, N., Mizuno, A., Higashio, K., Takahashi, N., Suda, T., et al. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1787 · Cited by 278
Self-citationOsteoprotegerin and RANK ligand expression in prostate cancer.
Brown, J. M., Corey, E., Lee, Z. D., True, L. D., Yun, T. J., Tondravi, M., & Vessella, R. L. (2001) · Urology · doi:10.1016/s0090-4295(00)01122-5 · Cited by 234
TRANCE is a TNF family member that regulates dendritic cell and osteoclast function
Wong, B. R., Josien, R., & Choi, Y. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.6.715 · Cited by 230
Lossdörfer, S., Schwartz, Z., Wang, L., Lohmann, C. H., Turner, J. D., Wieland, M., Cochran, D. L., & Boyan, B. D. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30025 · Cited by 229
Pathogenesis of Age-Related Bone Loss in Humans
Khosla, S. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls163 · Cited by 222
Locklin, R. M., Khosla, S., Turner, R. T., & Riggs, B. L. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10490 · Cited by 219
Rogers, A., & Eastell, R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0794 · Cited by 215
HOROWITZ, M., Xi, Y., WILSON, K., & Kacena, M. A. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00030-7 · Cited by 215
Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice
Chagraoui, H., Komura, E., Tulliez, M., Giraudier, S., Vainchenker, W., & Wendling, F. (2002) · Blood · doi:10.1182/blood-2002-04-1133 · Cited by 238
Filvaroff, E. H., Erlebacher, A., Ye, J., Gitelman, S. E., Lotz, J. C., Heilman, M., & Derynck, R. (1999) · Development · doi:10.1242/dev.126.19.4267 · Cited by 212
A role for TGFβ1 in osteoclast differentiation and survival
Fuller, K., Lean, J. M., Bayley, K. E., Wani, M. R., & Chambers, T. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.13.2445 · Cited by 197
Johnson, K., Goding, J. W., Etten, D. V., Sali, A., Hu, S., FARLEY, D. L., Krug, H. E., Hessle, L., Millán, J. L., & Terkeltaub, R. A. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.994 · Cited by 198
Authentic Matrix Vesicles Contain Active Metalloproteases (MMP)
D’Angelo, M., Billings, P. C., Pacifici, M., Leboy, P. S., & Kirsch, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009725200 · Cited by 195
Saika, M., Inoue, D., Kido, S., & Matsumoto, T. (2001) · Endocrinology · doi:10.1210/endo.142.6.8220 · Cited by 194
Polymorphisms in the Osteoprotegerin Gene Are Associated With Osteoporotic Fractures
Langdahl, B. L., Carstens, M., Stenkjær, L. L., & Eriksen, E. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.7.1245 · Cited by 190
Heino, T. J., Hentunen, T. A., & Väänänen, H. K. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10109 · Cited by 191
Karst, M., Gorny, G., Galvin, R. J. S., & Oursler, M. J. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20036 · Cited by 184
Genetic Disorders of the Skeleton: A Developmental Approach
Kornak, U., & Mundlos, S. (2003) · The American Journal of Human Genetics · doi:10.1086/377110 · Cited by 183
Kanematsu, M., Sato, T., Takai, H., Watanabe, K., Ikeda, K., & Yamada, Y. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.7.1321 · Cited by 173
Self-citationHofbauer, L. C., & Heufelder, A. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6702 · Cited by 178
Zannettino, A. C. W., Holding, C. A., Diamond, P., Atkins, G. J., Kostakis, P., Farrugia, A., Gamble, J. R., To, L. B., Findlay, D. M., & Haynes, D. R. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20354 · Cited by 169
Rausch‐Fan, X., Qu, Z., Wieland, M., Matejka, M., & Schedle, A. (2007) · Dental Materials · doi:10.1016/j.dental.2007.03.001 · Cited by 151
Molecular mechanisms underlying osteoclast formation and activation
Troen, B. R. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00069-x · Cited by 154
Root resorption and the OPG/RANKL/RANK system: a mini review
Tyrovola, J. B., Spyropoulos, M. N., Makou, M., & Perrea, D. N. (2008) · Journal of Oral Science · doi:10.2334/josnusd.50.367 · Cited by 143
TGF-β in cancer and bone: Implications for treatment of bone metastases
Juárez, P., & Guise, T. A. (2010) · Bone · doi:10.1016/j.bone.2010.08.004 · Cited by 153
Zou, W., Hakim, I., Tschoep, K., Endres, S., & Bar‐Shavit, Z. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1202 · Cited by 143
Karsdal, M. A., Hjorth, P., Henriksen, K., Kirkegaard, T., Nielsen, K. L., Lou, H., Delaissé, J., & Foged, N. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303905200 · Cited by 137
Stimulation of Osteoprotegerin (OPG) Gene Expression by Transforming Growth Factor-β (TGF-β)
Thirunavukkarasu, K., Miles, R. R., Halladay, D., Yang, X., Galvin, R. J. S., Chandrasekhar, S., Martin, T. J., & Onyia, J. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104319200 · Cited by 142
Role of periodontal ligament fibroblasts in osteoclastogenesis: a review
Sokos, D., Everts, V. E., & de Vries, T. J. (2014) · Journal of Periodontal Research · doi:10.1111/jre.12197 · Cited by 141
Galvin, R. J. S., Gatlin, C. L., Horn, J. W., & Fuson, T. R. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1632 · Cited by 132
TGF-beta1 on osteoimmunology and the bone component cells
Kasagi, S., & Chen, W. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-4 · Cited by 131
Kuroda, S., Oyasu, M., Kawakami, M., Kanayama, N., Tanizawa, K., Saito, N., Abe, T., Matsuhashi, S., & Ting, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1638 · Cited by 131
Pathophysiological roles of osteoprotegerin (OPG)
Reid, P., & Holen, I. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.06.004 · Cited by 131
Regulatory roles and molecular signaling of TNF family members in osteoclasts
Feng, X. (2005) · Gene · doi:10.1016/j.gene.2005.01.014 · Cited by 132
Fazzalari, N. L., Kuliwaba, J. S., Atkins, G. J., Forwood, M. R., & Findlay, D. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.6.1015 · Cited by 129
Kubota, K., Sakikawa, C., Katsumata, M., Nakamura, T., & Wakabayashi, K. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.257 · Cited by 132
Janssens, K., ten Dijke, P., Ralston, S. H., Bergmann, C., & Hul, W. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208857200 · Cited by 122
Kobayashi, Y., Hashimoto, F., Miyamoto, H., Kanaoka, K., Miyazaki-Kawashita, Y., Nakashima, T., Shibata, M., Kobayashi, K., Kato, Y., & Sakai, H. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.10.1924 · Cited by 121
Hofbauer, L. C. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1410195 · Cited by 120
Kaneda, T., Nojima, T., Nakagawa, M., Ogasawara, A., Kaneko, H., Sato, T., Mano, H., Kumegawa, M., & Hakeda, Y. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4254 · Cited by 120
Transforming growth factor-β induces osteoclast formation in the absence of RANKL
Itonaga, I., Sabokbar, A., Sun, S. G., Kudo, O., Danks, L., Ferguson, D. J. P., Fujikawa, Y., & Athanasou, N. A. (2003) · Bone · doi:10.1016/j.bone.2003.08.008 · Cited by 119
Oshiro, T., Shiotani, A., Shibasaki, Y., & Sasaki, T. (2002) · The Anatomical Record · doi:10.1002/ar.10061 · Cited by 115
Fan, X., Roy, E., Zhu, L., Murphy, T. C., Ackert‐Bicknell, C. L., Hart, C. M., Rosen, C. J., Nanes, M. S., & Rubin, J. E. (2003) · Endocrinology · doi:10.1210/en.2003-0726 · Cited by 119
Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement
Mandelin, J. M., Li, T.-F., Liljeström, M., Kroon, M. E., Hanemaaijer, R., Santavirta, S. S., & Konttinen, Y. T. (2003) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.85b8.13311 · Cited by 117
Hasegawa, T., Yoshimura, Y., Kikuiri, T., Yawaka, Y., Takeyama, S., Matsumoto, A., Oguchi, H., & Shirakawa, T. (2002) · Journal of Periodontal Research · doi:10.1034/j.1600-0765.2002.01603.x · Cited by 116
TGF-β Family Signaling in Connective Tissue and Skeletal DiseasesPreprint
MacFarlane, E. G., Haupt, J., Dietz, H. C., & Shore, E. M. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022269 · Cited by 125
Functional α1‐ and β2‐adrenergic receptors in human osteoblasts
Huang, H., Brennan‐Speranza, T. C., Muir, M. M., & Mason, R. S. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21761 · Cited by 115
Osteoclast formation and resorption
Lerner, U. H. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00052-4 · Cited by 118
Koide, M., Murase, Y., Yamato, K., Noguchi, T., Okahashi, N., & Nishihara, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0715 · Cited by 109
Regulation of osteoclastogenesis and RANK expression by TGF‐β1
Yan, T., Riggs, B. L., Boyle, W. J., & Khosla, S. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1200 · Cited by 109
RANK-Fc: A therapeutic antagonist for RANK-L in myeloma
Sordillo, E. M., & Pearse, R. N. (2003) · Cancer · doi:10.1002/cncr.11134 · Cited by 109
The Role of Mast Cells in Bone Metabolism and Bone Disorders
Ragipoglu, D., Dudeck, A., Haffner‐Luntzer, M., Voß, M., Kroner, J., Ignatius, A. A., & Fischer, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00163 · Cited by 109
Smad4 is required for maintaining normal murine postnatal bone homeostasis
Tan, X., Weng, T., Zhang, J., Jian, W., Li, W., Wan, H., Lan, Y., Cheng, X., Hou, N., Liu, H., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.03466 · Cited by 108
Transcriptional Mechanisms of Bone Morphogenetic Protein-induced Osteoprotegrin Gene Expression
Wan, M., Shi, X., Feng, X., & Cao, X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006918200 · Cited by 104
Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels
Kondo, T., Kitazawa, R., Yamaguchi, A., & Kitazawa, S. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21414 · Cited by 103
Sakata, M., Shiba, H., Komatsuzawa, H., Fujita, T., Ohta, K., Sugai, M., Suginaka, H., & Kurihara, H. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.9.1486 · Cited by 103
Ofotokun, I., McIntosh, E. B., & Weitzmann, M. N. (2011) · Current HIV/AIDS Reports · doi:10.1007/s11904-011-0099-z · Cited by 99
Chagraoui, H., Tulliez, M., Smayra, T., Komura, E., Giraudier, S., Yun, T. J., Lassau, N., Vainchenker, W., & Wendling, F. (2003) · Blood · doi:10.1182/blood-2002-09-2839 · Cited by 97
RANKL-independent modulation of osteoclastogenesis
Feng, W., Guo, J., & Li, M. (2019) · Journal of Oral Biosciences · doi:10.1016/j.job.2019.01.001 · Cited by 99
Kanzaki, H., Chiba, M., Satô, A., Miyagawa, A., Arai, K., NUKATSUKA, S., & Mitani, H. (2006) · Journal of Dental Research · doi:10.1177/154405910608500512 · Cited by 96
Buckley, K. M., Hipskind, R. A., Gartland, A., Bowler, W. B., & Gallagher, J. A. (2002) · Bone · doi:10.1016/s8756-3282(02)00877-3 · Cited by 98
Role of the RANK/RANKL/OPG and Wnt/β-Catenin Systems in CKD Bone and Cardiovascular Disorders
Workgroup, O. B. O. T. E. R. O. (., Carrillo-López, N., Martínez-Arias, L., Fernández-Villabrille, S., Ruiz-Torres, M. P., Dusso, A., Cannata-Andía, J. B., Naves-Díaz, M., & Panizo, S. (2021) · Calcified Tissue International · doi:10.1007/s00223-020-00803-2 · Cited by 91
Current insights into the role of transforming growth factor-β in bone resorption
Fox, S. W., & Lovibond, A. C. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.09.008 · Cited by 90
Ernst, C. W. O., Lee, J. E., Nakanishi, T., Karimbux, N. Y., Rezende, T. M. B., Stashenko, P., Seki, M., Taubman, M. A., & Kawai, T. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03318.x · Cited by 89
Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis
Reiman, R. M., Gerard, C. J., Campbell, I. L., & Barnum, S. R. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200204)32:4 · Cited by 53
Ishida, A., Fujita, N., Kitazawa, R., & Tsuruo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111093200 · Cited by 86
Interleukin-18 Up-Regulates Osteoprotegerin Expression in Stromal/Osteoblastic Cells
Makiishi-Shimobayashi, C., Tsujimura, T., Iwasaki, T., Yamada, N., Sugihara, A., Okamura, H., Hayashi, S., & Terada, N. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4380 · Cited by 86
Darnay, B. G., & Aggarwal, B. B. (1999) · Annals of the Rheumatic Diseases · doi:10.1136/ard.58.2008.i2 · Cited by 84
Macrophage lineage phenotypes and osteoclastogenesis—Complexity in the control by GM-CSF and TGF-β
Lari, R., Fleetwood, A. J., Kitchener, P. D., Cook, A. D., Pavasovic, D., Hertzog, P. J., & Hamilton, J. A. (2006) · Bone · doi:10.1016/j.bone.2006.09.003 · Cited by 85
Estrogen Modulates Cytokine Expression in Human Periodontal Ligament Cells
Shu, L., Guan, S., Fu, S., Guo, T., Cao, M., & Ding, Y. (2008) · Journal of Dental Research · doi:10.1177/154405910808700214 · Cited by 82
Metadata
- Authors
- Takai, H., Kanematsu, M., Yano, K., Tsuda, E., Higashio, K., Ikeda, K., Watanabe, K., & Yamada, Y.
- Affiliations
- Megmilk Snow Brand (Japan) (JP)
- Corresponding author
- Yamada, Yoshiji
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 273
- Issue
- 42
- Pages
- 27091-27096
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1994756823
- Cited by
- 299
- References
- 38
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- osteoprotegerin, TGF-β1, mesenchymal stem cells, RANKL, osteoclastogenesis, bone resorption, osteoblasts, transcriptional regulation, post-transcriptional regulation, osteoclast-like cells, 1,25-dihydroxyvitamin D3
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Cell Line, Dose-Response Relationship, Drug, Gene Expression Regulation, Glycoproteins, Models, Biological, Osteoclasts, RNA, Messenger, Transforming Growth Factor beta, Stromal Cells, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Mice, Osteoprotegerin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
